TFG


Summary: There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
TRK-fused geneMIM:602498Ensembl:ENSG00000114354HGNC:HGNC:11758PA364733q12.2

GO terms in TFG


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0000139Golgi membrane
CCNASGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCIDAGO:0070971endoplasmic reticulum exit site
BPIMPGO:0006888ER to Golgi vesicle-mediated transport
BPHMPGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPTASGO:0048208COPII vesicle coating
MFIPIGO:0005515protein binding
MFIPIGO:0042802identical protein binding

Gene expression in normal tissue: TFG

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TFG


DatabasePathway IDPathway Des.
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05216Thyroid cancer - Homo sapiens (human)
netpathPathway_EGFR1EGFR1
reactomeR-HSA-199977ER to Golgi Anterograde Transport
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-204005COPII-mediated vesicle transport
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-446203Asparagine N-linked glycosylation
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-948021Transport to the Golgi and subsequent modification

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD446LY 21832403
iGMDRD193Fqi11
iGMDRD639YK 4-2793
iGMDRD781Sirolimus9
iGMDRD151CHM-13
iGMDRD60Quinoclamine6
iGMDRD300Tozasertib3
iGMDRD886Compound 1541A3
iGMDRD505Pevonedistat3
iGMDRD451Serdemetan2
iGMDRD23Gossypol3
iGMDRD356PNU-746543
iGMDRD100Zebularine2
iGMDRD506Fedratinib3
iGMDRD870BRD636104
iGMDRD187BRD98761
iGMDRD267Oligomycin A3
iGMDRD474Avrainvillamide3
iGMDRD513BML-2591
iGMDRD260FQI-23

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TFG

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