TFG
Summary: There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TRK-fused gene | MIM:602498 | Ensembl:ENSG00000114354 | HGNC:HGNC:11758 | PA36473 | 3q12.2 |
GO terms in TFG
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | NAS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0070971 | endoplasmic reticulum exit site |
| BP | IMP | GO:0006888 | ER to Golgi vesicle-mediated transport |
| BP | HMP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | TAS | GO:0048208 | COPII vesicle coating |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
Gene expression in normal tissue: TFG
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TFG
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05216 | Thyroid cancer - Homo sapiens (human) |
| netpath | Pathway_EGFR1 | EGFR1 |
| reactome | R-HSA-199977 | ER to Golgi Anterograde Transport |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-204005 | COPII-mediated vesicle transport |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-948021 | Transport to the Golgi and subsequent modification |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD781 | Sirolimus | 9 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD60 | Quinoclamine | 6 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD870 | BRD63610 | 4 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD260 | FQI-2 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TFG
CLASSFICATION
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