TFG

Summary: There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameTRK-fused gene
OMIM IDMIM:602498
Ensembl IDEnsembl:ENSG00000114354
HGNC IDHGNC:HGNC:11758
PHARMGKB IDPA36473
Map Location3q12.2

GO terms in TFG


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IEA GO:0000139 Golgi membrane
CC NAS GO:0005737 cytoplasm
CC TAS GO:0005829 cytosol
CC IDA GO:0070971 endoplasmic reticulum exit site
BP IMP GO:0006888 ER to Golgi vesicle-mediated transport
BP HMP GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
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Gene expression in normal tissue: TFG

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined15Other, kinases1Biosynthesis of secondary metabolites1Mitosis1Longevity regulating pathway1p53 pathway1

Pathways in TFG


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Database
Pathway ID
Pathway Des.
kegg hsa05200 Pathways in cancer - Homo sapiens (human)
kegg hsa05216 Thyroid cancer - Homo sapiens (human)
netpath Pathway_EGFR1 EGFR1
reactome R-HSA-199977 ER to Golgi Anterograde Transport
reactome R-HSA-199991 Membrane Trafficking
reactome R-HSA-204005 COPII-mediated vesicle transport
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD446 LY 2183240 3
iGMDRD193 Fqi1 1
iGMDRD639 YK 4-279 3
iGMDRD781 Sirolimus 9
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TFG

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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