F8


Summary: This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
coagulation factor VIIIMIM:300841Ensembl:ENSG00000185010HGNC:HGNC:3546PA27952Xq28

Gene Categories:

DRUGGABLE GENOME

GO terms in F8


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0005507copper ion binding
MFIPIGO:0005515protein binding
MFIEAGO:0016491oxidoreductase activity
MFIBAGO:0070492oligosaccharide binding
BPTASGO:0002576platelet degranulation
BPTASGO:0006888ER to Golgi vesicle-mediated transport
BPIEAGO:0006953acute-phase response
BPTASGO:0007596blood coagulation
BPIBAGO:0007597blood coagulation, intrinsic pathway
BPTASGO:0007597blood coagulation, intrinsic pathway
BPIEAGO:0030168platelet activation
BPTASGO:0048208COPII vesicle coating
BPIEAGO:0055114oxidation-reduction process
CCIEAGO:0000139Golgi membrane
CCNASGO:0005576extracellular region
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCIEAGO:0005615extracellular space
CCTASGO:0005788endoplasmic reticulum lumen
CCTASGO:0005886plasma membrane
CCTASGO:0030134COPII-coated ER to Golgi transport vesicle
CCTASGO:0031093platelet alpha granule lumen
CCTASGO:0033116endoplasmic reticulum-Golgi intermediate compartment membrane

Gene expression in normal tissue: F8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in F8


DatabasePathway IDPathway Des.
biocartaintrinsicpathwayintrinsic prothrombin activation pathway
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-114608Platelet degranulation
reactomeR-HSA-140837Intrinsic Pathway of Fibrin Clot Formation
reactomeR-HSA-140875Common Pathway of Fibrin Clot Formation
reactomeR-HSA-140877Formation of Fibrin Clot (Clotting Cascade)
reactomeR-HSA-199977ER to Golgi Anterograde Transport
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-204005COPII-mediated vesicle transport
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-446203Asparagine N-linked glycosylation
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-5694530Cargo concentration in the ER
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76005Response to elevated platelet cytosolic Ca2+
reactomeR-HSA-948021Transport to the Golgi and subsequent modification
smpdbSMP00268Warfarin Action Pathway
smpdbSMP00269Acenocoumarol Action Pathway
smpdbSMP00270Dicumarol Action Pathway
smpdbSMP00271Phenprocoumon Action Pathway
smpdbSMP00272Enoxaparin Action Pathway
smpdbSMP00273Fondaparinux Action Pathway
smpdbSMP00274Heparin Action Pathway
smpdbSMP00275Ardeparin Action Pathway
smpdbSMP00276Argatroban Action Pathway
smpdbSMP00277Bivalirudin Action Pathway
smpdbSMP00278Lepirudin Action Pathway
smpdbSMP00279Ximelagatran Action Pathway
smpdbSMP00280Alteplase Action Pathway
smpdbSMP00281Anistreplase Action Pathway
smpdbSMP00282Streptokinase Action Pathway
smpdbSMP00283Tenecteplase Action Pathway
smpdbSMP00284Urokinase Action Pathway
smpdbSMP00285Reteplase Action Pathway
smpdbSMP00286Aminocaproic Acid Action Pathway
smpdbSMP00287Tranexamic Acid Action Pathway
smpdbSMP00288Aprotinin Action Pathway
smpdbSMP00586Coagulation
smpdbSMP00655Phenindione Action Pathway
smpdbSMP00656Dicoumarol Action Pathway
wikipathwaysWP272Blood Clotting Cascade
wikipathwaysWP3896Dengue-2 Interactions with Complement and Coagulation Cascades
wikipathwaysWP3897Dengue-2 Interactions with Blood Clotting Cascade
wikipathwaysWP558Complement and Coagulation Cascades
kegghsa04610Complement and coagulation cascades - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD872BRD71372
iGMDRD286Nsc 6328392
iGMDRD871BRD63684
iGMDRD662JQ-12
iGMDRD329Merck603
iGMDRD263AACOCF31
iGMDRD552AZD-17752
iGMDRD246NPC262
iGMDRD886Compound 1541A1
iGMDRD505Pevonedistat4
iGMDRD322FK 8662
iGMDRD121GMX17782
iGMDRD434BMS-5369241
iGMDRD289Parthenolide3
iGMDRD705Nakiterpiosin2
iGMDRD213SMR0000686502
iGMDRD267Oligomycin A3
iGMDRD85Ursolic acid1
iGMDRD698Neratinib2
iGMDRD351GW843682X1
iGMDRD123Isoevodiamine3
iGMDRD901ELCPK2
iGMDRD211(1S,3R)-RSL31
iGMDRD435BI-25362
iGMDRD132(-)-gallocatechin-3-O-gallate4
iGMDRD945ML2143
iGMDRD307Manumycin A2
iGMDRD486Tosedostat1
iGMDRD84Lovastatin acid4
iGMDRD512nutlin 33
iGMDRD424Tamatinib3
iGMDRD150RITA3
iGMDRD583LDN 1931891
iGMDRD188Piperlongumine4
iGMDRD888Compound 448
iGMDRD577BIX012941
iGMDRD506Fedratinib1
iGMDRD64Parbendazole6
iGMDRD23Gossypol1
iGMDRD474Avrainvillamide4
iGMDRD138PX 126
iGMDRD260FQI-22
iGMDRD870BRD636102
iGMDRD226ML0061
iGMDRD446LY 21832404
iGMDRD193Fqi13
iGMDRD466Chaetocin1
iGMDRD280CYTOCHALASIN B5
iGMDRD679Bistramide A3
iGMDRD297Austocystin D3
iGMDRD634SCHEMBL26080412
iGMDRD1593-Chloro-L-alanine1
iGMDRD151CHM-12
iGMDRD433Lexibulin2
iGMDRD772BRD47702
iGMDRD670ML 2103
iGMDRD779PRL-3 Inhibitor I1
iGMDRD781Sirolimus2
iGMDRD483SCH-5290741

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in F8

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