ITK
Summary: This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| IL2 inducible T cell kinase | MIM:186973 | Ensembl:ENSG00000113263 | HGNC:HGNC:6171 | PA29968 | 5q33.3 |
GO terms in ITK
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | IDA | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | IBA | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | ISS | GO:0001816 | cytokine production |
| BP | IBA | GO:0001865 | NK T cell differentiation |
| BP | IBA | GO:0002250 | adaptive immune response |
| BP | ISS | GO:0002250 | adaptive immune response |
| BP | TAS | GO:0006968 | cellular defense response |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | ISS | GO:0007202 | activation of phospholipase C activity |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IEA | GO:0032609 | interferon-gamma production |
| BP | IEA | GO:0032633 | interleukin-4 production |
| BP | IEA | GO:0035556 | intracellular signal transduction |
| BP | IBA | GO:0038083 | peptidyl-tyrosine autophosphorylation |
| BP | TAS | GO:0038095 | Fc-epsilon receptor signaling pathway |
| BP | TAS | GO:0042110 | T cell activation |
| BP | IBA | GO:0042127 | regulation of cell proliferation |
| BP | IBA | GO:0045087 | innate immune response |
| BP | IBA | GO:0050852 | T cell receptor signaling pathway |
| BP | ISS | GO:0050852 | T cell receptor signaling pathway |
| BP | TAS | GO:0050852 | T cell receptor signaling pathway |
| BP | IBA | GO:0050853 | B cell receptor signaling pathway |
| CC | ISS | GO:0005634 | nucleus |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005911 | cell-cell junction |
| CC | IBA | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
Gene expression in normal tissue: ITK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ITK
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | ctla4pathway | the co-stimulatory signal during t-cell activation |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-202403 | TCR signaling |
| reactome | R-HSA-202433 | Generation of second messenger molecules |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2871809 | FCERI mediated Ca+2 mobilization |
| reactome | R-HSA-2871809 | FCERI mediated Ca+2 mobilization |
| wikipathways | WP2583 | T-Cell Receptor and Co-stimulatory Signaling |
| wikipathways | WP3863 | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| pid | fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| pid | pi3kcipathway | Class I PI3K signaling events |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_TCR | TCR |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD263 | AACOCF3 | 3 |
| iGMDRD246 | NPC26 | 4 |
| iGMDRD42 | Vorinostat | 4 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD103 | SN-38 | 1 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD121 | GMX1778 | 4 |
| iGMDRD251 | ML162 | 7 |
| iGMDRD202 | Curcumin | 4 |
| iGMDRD6 | AM-580 | 1 |
| iGMDRD705 | Nakiterpiosin | 4 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD289 | Parthenolide | 5 |
| iGMDRD698 | Neratinib | 5 |
| iGMDRD901 | ELCPK | 4 |
| iGMDRD123 | Isoevodiamine | 5 |
| iGMDRD945 | ML214 | 6 |
| iGMDRD883 | CIL55A | 6 |
| iGMDRD486 | Tosedostat | 2 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD405 | PIK-75 | 1 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD577 | BIX01294 | 5 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD64 | Parbendazole | 6 |
| iGMDRD356 | PNU-74654 | 4 |
| iGMDRD513 | BML-259 | 4 |
| iGMDRD138 | PX 12 | 7 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD260 | FQI-2 | 5 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD885 | Compound 110 | 7 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD193 | Fqi1 | 6 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD152 | 179324-69-7 | 5 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD151 | CHM-1 | 5 |
| iGMDRD144 | NSC95397 | 8 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ITK
CLASSFICATION
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