ITK


Summary: This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
IL2 inducible T cell kinaseMIM:186973Ensembl:ENSG00000113263HGNC:HGNC:6171PA299685q33.3

GO terms in ITK


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004715non-membrane spanning protein tyrosine kinase activity
MFIDAGO:0004715non-membrane spanning protein tyrosine kinase activity
MFIBAGO:0005102signaling receptor binding
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0046872metal ion binding
BPISSGO:0001816cytokine production
BPIBAGO:0001865NK T cell differentiation
BPIBAGO:0002250adaptive immune response
BPISSGO:0002250adaptive immune response
BPTASGO:0006968cellular defense response
BPTASGO:0007165signal transduction
BPIBAGO:0007169transmembrane receptor protein tyrosine kinase signaling pathway
BPISSGO:0007202activation of phospholipase C activity
BPIBAGO:0030154cell differentiation
BPIEAGO:0032609interferon-gamma production
BPIEAGO:0032633interleukin-4 production
BPIEAGO:0035556intracellular signal transduction
BPIBAGO:0038083peptidyl-tyrosine autophosphorylation
BPTASGO:0038095Fc-epsilon receptor signaling pathway
BPTASGO:0042110T cell activation
BPIBAGO:0042127regulation of cell proliferation
BPIBAGO:0045087innate immune response
BPIBAGO:0050852T cell receptor signaling pathway
BPISSGO:0050852T cell receptor signaling pathway
BPTASGO:0050852T cell receptor signaling pathway
BPIBAGO:0050853B cell receptor signaling pathway
CCISSGO:0005634nucleus
CCTASGO:0005829cytosol
CCIEAGO:0005911cell-cell junction
CCIBAGO:0031234extrinsic component of cytoplasmic side of plasma membrane

Gene expression in normal tissue: ITK

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ITK


DatabasePathway IDPathway Des.
biocartactla4pathwaythe co-stimulatory signal during t-cell activation
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-202403TCR signaling
reactomeR-HSA-202433Generation of second messenger molecules
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2871809FCERI mediated Ca+2 mobilization
reactomeR-HSA-2871809FCERI mediated Ca+2 mobilization
wikipathwaysWP2583T-Cell Receptor and Co-stimulatory Signaling
wikipathwaysWP3863T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP69T-Cell antigen Receptor (TCR) Signaling Pathway
pidfcer1pathwayFc-epsilon receptor I signaling in mast cells
pidpi3kcipathwayClass I PI3K signaling events
pidtcr_pathwayTCR signaling in naïve CD4+ T cells
netpathPathway_BCRBCR
netpathPathway_TCRTCR
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04670Leukocyte transendothelial migration - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD286Nsc 6328394
iGMDRD414MST-3123
iGMDRD329Merck603
iGMDRD263AACOCF33
iGMDRD246NPC264
iGMDRD42Vorinostat4
iGMDRD322FK 8662
iGMDRD103SN-381
iGMDRD271Brefeldin A3
iGMDRD121GMX17784
iGMDRD251ML1627
iGMDRD202Curcumin4
iGMDRD6AM-5801
iGMDRD705Nakiterpiosin4
iGMDRD105Triptolide2
iGMDRD289Parthenolide5
iGMDRD698Neratinib5
iGMDRD901ELCPK4
iGMDRD123Isoevodiamine5
iGMDRD945ML2146
iGMDRD883CIL55A6
iGMDRD486Tosedostat2
iGMDRD116CD4372
iGMDRD405PIK-751
iGMDRD701NVP-AUY9222
iGMDRD188Piperlongumine5
iGMDRD506Fedratinib2
iGMDRD577BIX012945
iGMDRD562Navitoclax2
iGMDRD780PP-303
iGMDRD60Quinoclamine2
iGMDRD64Parbendazole6
iGMDRD356PNU-746544
iGMDRD513BML-2594
iGMDRD138PX 127
iGMDRD474Avrainvillamide2
iGMDRD260FQI-25
iGMDRD255SB2250022
iGMDRD318PAC-12
iGMDRD885Compound 1107
iGMDRD441TW 372
iGMDRD446LY 21832402
iGMDRD193Fqi16
iGMDRD61Kinetin riboside2
iGMDRD152179324-69-75
iGMDRD466Chaetocin2
iGMDRD394BX-7951
iGMDRD151CHM-15
iGMDRD144NSC953978

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ITK

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