CD79B
Summary: The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| CD79b molecule | MIM:147245 | Ensembl:ENSG00000007312 | HGNC:HGNC:1699 | PA26238 | 17q23.3 |
GO terms in CD79B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IMP | GO:0042803 | protein homodimerization activity |
| BP | IEA | GO:0002250 | adaptive immune response |
| BP | TAS | GO:0006955 | immune response |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0030183 | B cell differentiation |
| BP | IBA | GO:0050853 | B cell receptor signaling pathway |
| BP | IMP | GO:0051260 | protein homooligomerization |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0009897 | external side of plasma membrane |
| CC | IBA | GO:0019815 | B cell receptor complex |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: CD79B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CD79B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | bcr_5pathway | BCR signaling pathway |
| netpath | Pathway_BCR | BCR |
| kegg | hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-5690714 | CD22 mediated BCR regulation |
| reactome | R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
| reactome | R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| biocarta | bcrpathway | bcr signaling pathway |
| biocarta | ctcfpathway | ctcf: first multivalent nuclear factor |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD679 | Bistramide A | 5 |
| iGMDRD359 | OSW-1 | 3 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD885 | Compound 110 | 6 |
| iGMDRD318 | PAC-1 | 7 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD524 | ISX-9 | 6 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD267 | Oligomycin A | 6 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD872 | BRD7137 | 6 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD886 | Compound 1541A | 6 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD353 | PD0325901 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CD79B
CLASSFICATION
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