CD79B

Summary: The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameCD79b molecule
OMIM IDMIM:147245
Ensembl IDEnsembl:ENSG00000007312
HGNC IDHGNC:HGNC:1699
PHARMGKB IDPA26238
Map Location17q23.3

GO terms in CD79B


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0004888 transmembrane signaling receptor activity
MF IPI GO:0005515 protein binding
MF IMP GO:0042803 protein homodimerization activity
BP IEA GO:0002250 adaptive immune response
BP TAS GO:0006955 immune response
BP TAS GO:0007165 signal transduction
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Gene expression in normal tissue: CD79B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined21PI3K/MTOR signaling2Apoptosis regulation2ERK MAPK signaling2Mitosis1IGFR signaling1Chromatin histone acetylation1Other, kinases1Longevity regulating pathway1

Pathways in CD79B


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Database
Pathway ID
Pathway Des.
pid bcr_5pathway BCR signaling pathway
netpath Pathway_BCR BCR
kegg hsa04662 B cell receptor signaling pathway - Homo sapiens (human)
wikipathways WP23 B Cell Receptor Signaling Pathway
reactome R-HSA-1280218 Adaptive Immune System
reactome R-HSA-1280218 Adaptive Immune System
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD126 Tipifarnib 3
iGMDRD889 Compound 7d-cis 3
iGMDRD1008 SR-II-138A 3
iGMDRD546 BMS-754807 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CD79B

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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