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FOXE1

Summary: This intronless gene encodes a protein that belongs to the forkhead family of transcription factors. Members of this family contain a conserved 100-amino acid DNA-binding 'forkhead' domain. The encoded protein functions as a thyroid transcription factor that plays a role in thyroid morphogenesis. Mutations in this gene are associated with the Bamforth-Lazarus syndrome, and with susceptibility to nonmedullary thyroid cancer-4. [provided by RefSeq, Nov 2016].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
forkhead box E1	MIM:602617	Ensembl:ENSG00000178919	HGNC:HGNC:3806	PA28223	9q22.33

GO terms in FOXE1

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	IDA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	IMP	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISM	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	NAS	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	IDA	GO:0003700	DNA-binding transcription factor activity
MF	IDA	GO:0043565	sequence-specific DNA binding
MF	IMP	GO:0043565	sequence-specific DNA binding
BP	ISS	GO:0000122	negative regulation of transcription by RNA polymerase II
BP	NAS	GO:0000122	negative regulation of transcription by RNA polymerase II
BP	IEA	GO:0006351	transcription, DNA-templated
BP	IBA	GO:0006357	regulation of transcription by RNA polymerase II
BP	IDA	GO:0006357	regulation of transcription by RNA polymerase II
BP	IMP	GO:0006357	regulation of transcription by RNA polymerase II
BP	ISS	GO:0006590	thyroid hormone generation
BP	IBA	GO:0009653	anatomical structure morphogenesis
BP	NAS	GO:0009653	anatomical structure morphogenesis
BP	ISS	GO:0016477	cell migration
BP	IBA	GO:0030154	cell differentiation
BP	IEP	GO:0030878	thyroid gland development
BP	IMP	GO:0030878	thyroid gland development
BP	ISS	GO:0031069	hair follicle morphogenesis
BP	ISS	GO:0045892	negative regulation of transcription, DNA-templated
BP	IDA	GO:0045893	positive regulation of transcription, DNA-templated
BP	IEP	GO:0048538	thymus development
BP	ISS	GO:0048562	embryonic organ morphogenesis
BP	IMP	GO:0060022	hard palate development
BP	IMP	GO:0060023	soft palate development
BP	IEP	GO:0060465	pharynx development
BP	IEA	GO:1904888	cranial skeletal system development
CC	IBA	GO:0005634	nucleus
CC	IDA	GO:0005634	nucleus

Gene expression in normal tissue: FOXE1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FOXE1

Database	Pathway ID	Pathway Des.

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD132	(-)-gallocatechin-3-O-gallate	4
iGMDRD154	NSC23766	3
iGMDRD446	LY 2183240	4
iGMDRD341	Triacsin c	2
iGMDRD144	NSC95397	5
iGMDRD494	Neopeltolide	3
iGMDRD330	BRD4132	3
iGMDRD889	Compound 7d-cis	6
iGMDRD300	Tozasertib	2
iGMDRD886	Compound 1541A	3
iGMDRD60	Quinoclamine	3
iGMDRD268	Cerulenin	3
iGMDRD286	Nsc 632839	3
iGMDRD188	Piperlongumine	8
iGMDRD872	BRD7137	5
iGMDRD577	BIX01294	3
iGMDRD77	Itraconazole	5
iGMDRD474	Avrainvillamide	2
iGMDRD137	Indisulam	2
iGMDRD255	SB225002	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FOXE1

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.