PRKG2

Summary: This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein binds to and inhibits the activation of several receptor tyrosine kinases. The membrane-bound protein is a regulator of intestinal secretion, bone growth and renin secretion. Alternate splicing results in multiple transcript variants encoding distinct isoforms whose regulatory N-termini differ in length but whose C-terminal catalytic domains are identical. [provided by RefSeq, May 2018].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameprotein kinase cGMP-dependent 2
OMIM IDMIM:601591
Ensembl IDEnsembl:ENSG00000138669
HGNC IDHGNC:HGNC:9416
PHARMGKB IDPA33778
Map Location4q21.21

GO terms in PRKG2


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0005829 cytosol
CC IEA GO:0016324 apical plasma membrane
CC IEA GO:0031965 nuclear membrane
BP IMP GO:0006468 protein phosphorylation
BP TAS GO:0007165 signal transduction
BP IEA GO:0036289 peptidyl-serine autophosphorylation
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Gene expression in normal tissue: PRKG2

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 33undefinedtissue: undefined cancer: NON_SMALL_CELL_CARCINOMA model num: 3undefinedtissue: undefined cancer: SMALL_CELL_CARCINOMA model num: 3BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 13LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 15OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 3

Gene-drug pathway distribution

undefined17WNT signaling1PI3K/MTOR signaling1DNA replication1Chromatin histone acetylation1ERK MAPK signaling1Other, kinases1

Pathways in PRKG2


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Database
Pathway ID
Pathway Des.
biocarta no1pathway actions of nitric oxide in the heart
biocarta raccpathway ion channels and their functional role in vascular endothelium
reactome R-HSA-109582 Hemostasis
reactome R-HSA-109582 Hemostasis
reactome R-HSA-1430728 Metabolism
reactome R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD871 BRD6368 3
iGMDRD188 Piperlongumine 3
iGMDRD414 MST-312 3
iGMDRD399 Selumetinib 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRKG2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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