PRKG2


Summary: This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein binds to and inhibits the activation of several receptor tyrosine kinases. The membrane-bound protein is a regulator of intestinal secretion, bone growth and renin secretion. Alternate splicing results in multiple transcript variants encoding distinct isoforms whose regulatory N-termini differ in length but whose C-terminal catalytic domains are identical. [provided by RefSeq, May 2018].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
protein kinase cGMP-dependent 2MIM:601591Ensembl:ENSG00000138669HGNC:HGNC:9416PA337784q21.21

GO terms in PRKG2


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005829cytosol
CCIEAGO:0016324apical plasma membrane
CCIEAGO:0031965nuclear membrane
BPIMPGO:0006468protein phosphorylation
BPTASGO:0007165signal transduction
BPIEAGO:0036289peptidyl-serine autophosphorylation
BPTASGO:0051186cofactor metabolic process
BPIEAGO:0072659protein localization to plasma membrane
BPIEAGO:2001226negative regulation of chloride transport
MFTASGO:0004672protein kinase activity
MFTASGO:0004692cGMP-dependent protein kinase activity
MFIEAGO:0005524ATP binding
MFIEAGO:0030553cGMP binding
MFIEAGO:0042803protein homodimerization activity

Gene expression in normal tissue: PRKG2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRKG2


DatabasePathway IDPathway Des.
biocartano1pathwayactions of nitric oxide in the heart
biocartaraccpathwayion channels and their functional role in vascular endothelium
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1474151Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-196854Metabolism of vitamins and cofactors
reactomeR-HSA-3858494Beta-catenin independent WNT signaling
reactomeR-HSA-392154Nitric oxide stimulates guanylate cyclase
reactomeR-HSA-392154Nitric oxide stimulates guanylate cyclase
reactomeR-HSA-4086398Ca2+ pathway
reactomeR-HSA-418346Platelet homeostasis
reactomeR-HSA-418346Platelet homeostasis
reactomeR-HSA-418457cGMP effects
reactomeR-HSA-418457cGMP effects
reactomeR-HSA-8978934Metabolism of cofactors
wikipathwaysWP4008NO-cGMP-PKG mediated Neuroprotection
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04540Gap junction - Homo sapiens (human)
kegghsa04611Platelet activation - Homo sapiens (human)
kegghsa04713Circadian entrainment - Homo sapiens (human)
kegghsa04714Thermogenesis - Homo sapiens (human)
kegghsa04730Long-term depression - Homo sapiens (human)
kegghsa04740Olfactory transduction - Homo sapiens (human)
kegghsa04923Regulation of lipolysis in adipocytes - Homo sapiens (human)
kegghsa04924Renin secretion - Homo sapiens (human)
kegghsa04970Salivary secretion - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD871BRD63683
iGMDRD188Piperlongumine3
iGMDRD414MST-3123
iGMDRD399Selumetinib3
iGMDRD506Fedratinib1
iGMDRD888Compound 443
iGMDRD42Vorinostat3
iGMDRD524ISX-93
iGMDRD103SN-383
iGMDRD474Avrainvillamide2
iGMDRD434BMS-5369242
iGMDRD231Importazole1
iGMDRD870BRD636103
iGMDRD201SKI II3
iGMDRD61Kinetin riboside8
iGMDRD634SCHEMBL26080412
iGMDRD126Tipifarnib2
iGMDRD330BRD41323
iGMDRD387CHIR-990216
iGMDRD420Leucascandrolide A3
iGMDRD150RITA3
iGMDRD560MK-22064
iGMDRD424Tamatinib3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRKG2

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