PRKG2
Summary: This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein binds to and inhibits the activation of several receptor tyrosine kinases. The membrane-bound protein is a regulator of intestinal secretion, bone growth and renin secretion. Alternate splicing results in multiple transcript variants encoding distinct isoforms whose regulatory N-termini differ in length but whose C-terminal catalytic domains are identical. [provided by RefSeq, May 2018].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:601591 Ensembl IDEnsembl:ENSG00000138669 HGNC IDHGNC:HGNC:9416 PHARMGKB IDPA33778 Map Location4q21.21 |
GO terms in PRKG2
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | TAS | GO:0005829 | cytosol |
CC | IEA | GO:0016324 | apical plasma membrane |
CC | IEA | GO:0031965 | nuclear membrane |
BP | IMP | GO:0006468 | protein phosphorylation |
BP | TAS | GO:0007165 | signal transduction |
BP | IEA | GO:0036289 | peptidyl-serine autophosphorylation |
Gene expression in normal tissue: PRKG2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKG2
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Database | Pathway ID | Pathway Des. |
---|---|---|
biocarta | no1pathway | actions of nitric oxide in the heart |
biocarta | raccpathway | ion channels and their functional role in vascular endothelium |
reactome | R-HSA-109582 | Hemostasis |
reactome | R-HSA-109582 | Hemostasis |
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in PRKG2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |