PRKG2
Summary: This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein binds to and inhibits the activation of several receptor tyrosine kinases. The membrane-bound protein is a regulator of intestinal secretion, bone growth and renin secretion. Alternate splicing results in multiple transcript variants encoding distinct isoforms whose regulatory N-termini differ in length but whose C-terminal catalytic domains are identical. [provided by RefSeq, May 2018].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein kinase cGMP-dependent 2 | MIM:601591 | Ensembl:ENSG00000138669 | HGNC:HGNC:9416 | PA33778 | 4q21.21 |
GO terms in PRKG2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0016324 | apical plasma membrane |
| CC | IEA | GO:0031965 | nuclear membrane |
| BP | IMP | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0036289 | peptidyl-serine autophosphorylation |
| BP | TAS | GO:0051186 | cofactor metabolic process |
| BP | IEA | GO:0072659 | protein localization to plasma membrane |
| BP | IEA | GO:2001226 | negative regulation of chloride transport |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | TAS | GO:0004692 | cGMP-dependent protein kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0030553 | cGMP binding |
| MF | IEA | GO:0042803 | protein homodimerization activity |
Gene expression in normal tissue: PRKG2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKG2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | no1pathway | actions of nitric oxide in the heart |
| biocarta | raccpathway | ion channels and their functional role in vascular endothelium |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1474151 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-196854 | Metabolism of vitamins and cofactors |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-392154 | Nitric oxide stimulates guanylate cyclase |
| reactome | R-HSA-392154 | Nitric oxide stimulates guanylate cyclase |
| reactome | R-HSA-4086398 | Ca2+ pathway |
| reactome | R-HSA-418346 | Platelet homeostasis |
| reactome | R-HSA-418346 | Platelet homeostasis |
| reactome | R-HSA-418457 | cGMP effects |
| reactome | R-HSA-418457 | cGMP effects |
| reactome | R-HSA-8978934 | Metabolism of cofactors |
| wikipathways | WP4008 | NO-cGMP-PKG mediated Neuroprotection |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04540 | Gap junction - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04713 | Circadian entrainment - Homo sapiens (human) |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| kegg | hsa04730 | Long-term depression - Homo sapiens (human) |
| kegg | hsa04740 | Olfactory transduction - Homo sapiens (human) |
| kegg | hsa04923 | Regulation of lipolysis in adipocytes - Homo sapiens (human) |
| kegg | hsa04924 | Renin secretion - Homo sapiens (human) |
| kegg | hsa04970 | Salivary secretion - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD231 | Importazole | 1 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD201 | SKI II | 3 |
| iGMDRD61 | Kinetin riboside | 8 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD387 | CHIR-99021 | 6 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD150 | RITA | 3 |
| iGMDRD560 | MK-2206 | 4 |
| iGMDRD424 | Tamatinib | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRKG2
CLASSFICATION
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