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EPHA7

Summary: This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
EPH receptor A7	MIM:602190	Ensembl:ENSG00000135333	HGNC:HGNC:3390	PA27822	6q16.1

Gene Categories:

DRUGGABLE GENOME TYROSINE KINASE KINASE PROTEASE

GO terms in EPHA7

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0004709	MAP kinase kinase kinase activity
MF	IBA	GO:0004713	protein tyrosine kinase activity
MF	ISS	GO:0004713	protein tyrosine kinase activity
MF	IBA	GO:0004714	transmembrane receptor protein tyrosine kinase activity
MF	IBA	GO:0004888	transmembrane signaling receptor activity
MF	ISS	GO:0005004	GPI-linked ephrin receptor activity
MF	IBA	GO:0005005	transmembrane-ephrin receptor activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
MF	ISS	GO:0008046	axon guidance receptor activity
MF	IBA	GO:0031434	mitogen-activated protein kinase kinase binding
MF	ISS	GO:0045499	chemorepellent activity
MF	IEA	GO:0046875	ephrin receptor binding
BP	IEA	GO:0001934	positive regulation of protein phosphorylation
BP	IEA	GO:0006915	apoptotic process
BP	IBA	GO:0007275	multicellular organism development
BP	ISS	GO:0007420	brain development
BP	IBA	GO:0009968	negative regulation of signal transduction
BP	ISS	GO:0016310	phosphorylation
BP	IEA	GO:0018108	peptidyl-tyrosine phosphorylation
BP	ISS	GO:0022407	regulation of cell-cell adhesion
BP	IBA	GO:0030154	cell differentiation
BP	IEA	GO:0031290	retinal ganglion cell axon guidance
BP	ISS	GO:0031952	regulation of protein autophosphorylation
BP	IBA	GO:0033674	positive regulation of kinase activity
BP	IBA	GO:0043066	negative regulation of apoptotic process
BP	ISS	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process
BP	IBA	GO:0043410	positive regulation of MAPK cascade
BP	ISS	GO:0043525	positive regulation of neuron apoptotic process
BP	IDA	GO:0048013	ephrin receptor signaling pathway
BP	TAS	GO:0048013	ephrin receptor signaling pathway
BP	IEA	GO:0048671	negative regulation of collateral sprouting
BP	ISS	GO:0048755	branching morphogenesis of a nerve
BP	IDA	GO:0050730	regulation of peptidyl-tyrosine phosphorylation
BP	ISS	GO:0050919	negative chemotaxis
BP	IEA	GO:0051964	negative regulation of synapse assembly
BP	IDA	GO:0070372	regulation of ERK1 and ERK2 cascade
BP	IBA	GO:0070374	positive regulation of ERK1 and ERK2 cascade
BP	IEA	GO:0072178	nephric duct morphogenesis
CC	IBA	GO:0005737	cytoplasm
CC	TAS	GO:0005886	plasma membrane
CC	IBA	GO:0005887	integral component of plasma membrane
CC	IEA	GO:0005887	integral component of plasma membrane
CC	IEA	GO:0030425	dendrite
CC	IEA	GO:0031594	neuromuscular junction
CC	IBA	GO:0043005	neuron projection
CC	IEA	GO:0043025	neuronal cell body
CC	IBA	GO:0043235	receptor complex
CC	IEA	GO:0045211	postsynaptic membrane

Gene expression in normal tissue: EPHA7

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EPHA7

Database	Pathway ID	Pathway Des.
pid	epha_fwdpathway	EPHA forward signaling
kegg	hsa04360	Axon guidance - Homo sapiens (human)
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-2682334	EPH-Ephrin signaling
reactome	R-HSA-2682334	EPH-Ephrin signaling
reactome	R-HSA-3928663	EPHA-mediated growth cone collapse
reactome	R-HSA-3928663	EPHA-mediated growth cone collapse
reactome	R-HSA-3928665	EPH-ephrin mediated repulsion of cells
reactome	R-HSA-3928665	EPH-ephrin mediated repulsion of cells
reactome	R-HSA-422475	Axon guidance
reactome	R-HSA-422475	Axon guidance

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD599	Salermide	1
iGMDRD76	Simvastatin	3
iGMDRD126	Tipifarnib	4
iGMDRD433	Lexibulin	1
iGMDRD781	Sirolimus	2
iGMDRD670	ML 210	2
iGMDRD144	NSC95397	6
iGMDRD427	ABT737	3
iGMDRD61	Kinetin riboside	7
iGMDRD152	179324-69-7	6
iGMDRD446	LY 2183240	2
iGMDRD280	CYTOCHALASIN B	2
iGMDRD679	Bistramide A	1
iGMDRD474	Avrainvillamide	4
iGMDRD138	PX 12	5
iGMDRD318	PAC-1	5
iGMDRD52	Rotenone	4
iGMDRD187	BRD9876	1
iGMDRD870	BRD63610	4
iGMDRD782	DC-45-A2	2
iGMDRD506	Fedratinib	2
iGMDRD562	Navitoclax	5
iGMDRD188	Piperlongumine	2
iGMDRD100	Zebularine	2
iGMDRD74	Idarubicin	3
iGMDRD451	Serdemetan	2
iGMDRD60	Quinoclamine	2
iGMDRD84	Lovastatin acid	3
iGMDRD486	Tosedostat	3
iGMDRD330	BRD4132	2
iGMDRD79	Gemcitabine	5
iGMDRD560	MK-2206	2
iGMDRD116	CD437	1
iGMDRD57	Chloropentafluorobenzene	3
iGMDRD698	Neratinib	4
iGMDRD85	Ursolic acid	4
iGMDRD945	ML214	3
iGMDRD211	(1S,3R)-RSL3	3
iGMDRD177	Teniposide	2
iGMDRD5	Tyrphostin AG 1478	4
iGMDRD103	SN-38	2
iGMDRD137	Indisulam	4
iGMDRD251	ML162	4
iGMDRD121	GMX1778	7
iGMDRD202	Curcumin	3
iGMDRD158	NSC141540	2
iGMDRD289	Parthenolide	5
iGMDRD329	Merck60	3
iGMDRD366	PI-103	2
iGMDRD871	BRD6368	3
iGMDRD414	MST-312	2
iGMDRD872	BRD7137	3
iGMDRD42	Vorinostat	3
iGMDRD322	FK 866	1
iGMDRD505	Pevonedistat	3
iGMDRD263	AACOCF3	5
iGMDRD552	AZD-1775	5

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EPHA7

SITE

DATATYPES

CLASSFICATION

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