EPHA7


Summary: This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:602190
PHARMGKB IDPA27822
Map Location6q16.1

GO terms in EPHA7


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0004709 MAP kinase kinase kinase activity
MF IBA GO:0004713 protein tyrosine kinase activity
MF ISS GO:0004713 protein tyrosine kinase activity
MF IBA GO:0004714 transmembrane receptor protein tyrosine kinase activity
MF IBA GO:0004888 transmembrane signaling receptor activity
MF ISS GO:0005004 GPI-linked ephrin receptor activity
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Gene expression in normal tissue: EPHA7

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined39DNA replication2Apoptosis regulation2Chromatin histone acetylation2PI3K/MTOR signaling2Ferroptosis1Stilbenoid, diarylheptanoid and gingerol biosynthesis1Metabolism1p53 pathway1Longevity regulating pathway1

Pathways in EPHA7


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Database
Pathway ID
Pathway Des.
pid epha_fwdpathway EPHA forward signaling
kegg hsa04360 Axon guidance - Homo sapiens (human)
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-2682334 EPH-Ephrin signaling
reactome R-HSA-2682334 EPH-Ephrin signaling
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD599 Salermide 1
iGMDRD76 Simvastatin 3
iGMDRD126 Tipifarnib 4
iGMDRD433 Lexibulin 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EPHA7

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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