GLI1

Summary: This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameGLI family zinc finger 1
OMIM IDMIM:165220
Ensembl IDEnsembl:ENSG00000111087
HGNC IDHGNC:HGNC:4317
PHARMGKB IDPA28720
Map Location12q13.3

Gene Categories:

TUMOR SUPPRESSOR

GO terms in GLI1


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0001649 osteoblast differentiation
BP IEA GO:0006351 transcription, DNA-templated
BP IDA GO:0007224 smoothened signaling pathway
BP TAS GO:0007224 smoothened signaling pathway
BP IEA GO:0007283 spermatogenesis
BP IEA GO:0007418 ventral midline development
Showing 1 to 6 of 50 rows rows per page

Gene expression in normal tissue: GLI1

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 62LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 12BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 19UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 3

Gene-drug pathway distribution

undefined29Leukocyte transendothelial migration1Apoptosis regulation1Other, kinases1Cell cycle1Mitosis1DNA replication1

Pathways in GLI1


Loading, please wait...
Database
Pathway ID
Pathway Des.
wikipathways WP2855 Dopaminergic Neurogenesis
wikipathways WP3313 Hedgehog ,on, state
wikipathways WP3316 Hedgehog ,off, state
wikipathways WP3930 EDA Signalling in Hair Follicle Development
wikipathways WP4204 Tumor suppressor activity of SMARCB1
wikipathways WP4249 Hedgehog Signaling Pathway
Showing 1 to 6 of 23 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD886 Compound 1541A 2
iGMDRD300 Tozasertib 4
iGMDRD67 PENFLURIDOL 4
iGMDRD871 BRD6368 3
Showing 1 to 4 of 35 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GLI1

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.