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HIP1

Summary: The product of this gene is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein binds to the huntingtin protein in the brain; this interaction is lost in Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
huntingtin interacting protein 1	MIM:601767	Ensembl:ENSG00000127946	HGNC:HGNC:4913	PA29289	7q11.23

Gene Categories:

PROTEASE

GO terms in HIP1

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IEA	GO:0006351	transcription, DNA-templated
BP	IEA	GO:0006355	regulation of transcription, DNA-templated
BP	IDA	GO:0006915	apoptotic process
BP	IBA	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
BP	IDA	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
BP	IEA	GO:0007010	cytoskeleton organization
BP	IBA	GO:0007015	actin filament organization
BP	NAS	GO:0030100	regulation of endocytosis
BP	IEA	GO:0030154	cell differentiation
BP	IDA	GO:0042981	regulation of apoptotic process
BP	IMP	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway
BP	IBA	GO:0048260	positive regulation of receptor-mediated endocytosis
BP	IMP	GO:0048260	positive regulation of receptor-mediated endocytosis
BP	IBA	GO:0048268	clathrin coat assembly
BP	IDA	GO:0048268	clathrin coat assembly
BP	IDA	GO:0050821	protein stabilization
BP	IC	GO:0051897	positive regulation of protein kinase B signaling
BP	TAS	GO:0061024	membrane organization
BP	IEA	GO:0072583	clathrin-dependent endocytosis
BP	IDA	GO:0097190	apoptotic signaling pathway
BP	TAS	GO:0099637	neurotransmitter receptor transport
BP	IMP	GO:2000588	positive regulation of platelet-derived growth factor receptor-beta signaling pathway
CC	TAS	GO:0005634	nucleus
CC	IBA	GO:0005737	cytoplasm
CC	IDA	GO:0005737	cytoplasm
CC	IDA	GO:0005794	Golgi apparatus
CC	TAS	GO:0005829	cytosol
CC	TAS	GO:0005856	cytoskeleton
CC	TAS	GO:0016020	membrane
CC	IBA	GO:0030122	AP-2 adaptor complex
CC	IDA	GO:0030122	AP-2 adaptor complex
CC	IBA	GO:0030136	clathrin-coated vesicle
CC	IDA	GO:0030136	clathrin-coated vesicle
CC	IBA	GO:0030479	actin cortical patch
CC	IEA	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
CC	IBA	GO:0043231	intracellular membrane-bounded organelle
CC	IDA	GO:0043231	intracellular membrane-bounded organelle
CC	IBA	GO:0098793	presynapse
CC	IDA	GO:0098793	presynapse
CC	TAS	GO:0098794	postsynapse
CC	IEA	GO:0098888	extrinsic component of presynaptic membrane
CC	IBA	GO:0098890	extrinsic component of postsynaptic membrane
CC	IEA	GO:0098890	extrinsic component of postsynaptic membrane
MF	TAS	GO:0005154	epidermal growth factor receptor binding
MF	TAS	GO:0005200	structural constituent of cytoskeleton
MF	IPI	GO:0005515	protein binding
MF	IDA	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
MF	IBA	GO:0030276	clathrin binding
MF	IDA	GO:0030276	clathrin binding
MF	IBA	GO:0032051	clathrin light chain binding
MF	IPI	GO:0032051	clathrin light chain binding
MF	IDA	GO:0032266	phosphatidylinositol-3-phosphate binding
MF	IBA	GO:0035091	phosphatidylinositol binding
MF	IDA	GO:0035091	phosphatidylinositol binding
MF	TAS	GO:0035254	glutamate receptor binding
MF	IPI	GO:0035612	AP-2 adaptor complex binding
MF	IBA	GO:0035615	clathrin adaptor activity
MF	IC	GO:0035615	clathrin adaptor activity
MF	IDA	GO:0042803	protein homodimerization activity
MF	IBA	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding
MF	IDA	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding
MF	IPI	GO:0046982	protein heterodimerization activity
MF	IBA	GO:0051015	actin filament binding
MF	IDA	GO:0051015	actin filament binding
MF	IBA	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding
MF	IDA	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding

Gene expression in normal tissue: HIP1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HIP1

Database	Pathway ID	Pathway Des.
reactome	R-HSA-199991	Membrane Trafficking
reactome	R-HSA-5653656	Vesicle-mediated transport
reactome	R-HSA-8856828	Clathrin-mediated endocytosis
netpath	Pathway_EGFR1	EGFR1
pid	ar_pathway	Coregulation of Androgen receptor activity
kegg	hsa05016	Huntington,s disease - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD399	Selumetinib	3
iGMDRD506	Fedratinib	4
iGMDRD398	Sepantronium	3
iGMDRD64	Parbendazole	2
iGMDRD524	ISX-9	2
iGMDRD474	Avrainvillamide	1
iGMDRD260	FQI-2	2
iGMDRD255	SB225002	3
iGMDRD782	DC-45-A2	2
iGMDRD171	Pemetrexed	3
iGMDRD318	PAC-1	2
iGMDRD870	BRD63610	3
iGMDRD71	Sparfosic acid	3
iGMDRD679	Bistramide A	1
iGMDRD280	CYTOCHALASIN B	4
iGMDRD126	Tipifarnib	2
iGMDRD151	CHM-1	2
iGMDRD387	CHIR-99021	2
iGMDRD579	PF750	2
iGMDRD414	MST-312	2
iGMDRD329	Merck60	3
iGMDRD300	Tozasertib	1
iGMDRD82	Quiflapon	3
iGMDRD271	Brefeldin A	2
iGMDRD5	Tyrphostin AG 1478	2
iGMDRD705	Nakiterpiosin	2
iGMDRD481	Dactolisib	5
iGMDRD57	Chloropentafluorobenzene	1
iGMDRD351	GW843682X	4
iGMDRD237	ABT-751	1
iGMDRD154	NSC23766	4
iGMDRD307	Manumycin A	1
iGMDRD512	nutlin 3	1
iGMDRD424	Tamatinib	1
iGMDRD523	Cyanoquinoline, 11	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HIP1

SITE

DATATYPES

CLASSFICATION

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