HIP1

Summary: The product of this gene is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein binds to the huntingtin protein in the brain; this interaction is lost in Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namehuntingtin interacting protein 1
OMIM IDMIM:601767
Ensembl IDEnsembl:ENSG00000127946
HGNC IDHGNC:HGNC:4913
PHARMGKB IDPA29289
Map Location7q11.23

Gene Categories:

PROTEASE

GO terms in HIP1


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0006351 transcription, DNA-templated
BP IEA GO:0006355 regulation of transcription, DNA-templated
BP IDA GO:0006915 apoptotic process
BP IBA GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
BP IDA GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
BP IEA GO:0007010 cytoskeleton organization
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Gene expression in normal tissue: HIP1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined26Apoptosis regulation2PI3K/MTOR signaling1Cell cycle1Mitosis1One carbon pool by folate1Other, kinases1ERK MAPK signaling1WNT signaling1

Pathways in HIP1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-199991 Membrane Trafficking
reactome R-HSA-5653656 Vesicle-mediated transport
reactome R-HSA-8856828 Clathrin-mediated endocytosis
netpath Pathway_EGFR1 EGFR1
pid ar_pathway Coregulation of Androgen receptor activity
kegg hsa05016 Huntington,s disease - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD399 Selumetinib 3
iGMDRD506 Fedratinib 4
iGMDRD398 Sepantronium 3
iGMDRD64 Parbendazole 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HIP1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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