SGK1
Summary: This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:602958 Ensembl IDEnsembl:ENSG00000118515 HGNC IDHGNC:HGNC:10810 PHARMGKB IDPA162403013 Map Location6q23.2 | |||||
GO terms in SGK1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0001558 | regulation of cell growth |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0006814 | sodium ion transport |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IEA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | TAS | GO:0007616 | long-term memory |
Gene expression in normal tissue: SGK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SGK1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2035 | Follicle Stimulating Hormone (FSH) signaling pathway |
| wikipathways | WP3584 | MECP2 and Associated Rett Syndrome |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| pid | foxopathway | FoxO family signaling |
| pid | insulin_pathway | Insulin Pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SGK1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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