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GADD45A

Summary: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namegrowth arrest and DNA damage inducible alpha OMIM IDMIM:126335 Ensembl IDEnsembl:ENSG00000116717 HGNC IDHGNC:HGNC:4095 PHARMGKB IDPA28510 Map Location1p31.3

Gene Categories:

KINASE TUMOR SUPPRESSOR DNA REPAIR SERINE THREONINE KINASE

GO terms in GADD45A

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	TAS	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
BP	IBA	GO:0000185	activation of MAPKKK activity
BP	IDA	GO:0000185	activation of MAPKKK activity
BP	TAS	GO:0006281	DNA repair
BP	IEA	GO:0006469	negative regulation of protein kinase activity
BP	TAS	GO:0006915	apoptotic process

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Gene expression in normal tissue: GADD45A

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GADD45A

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-212436	Generic Transcription Pathway
reactome	R-HSA-3700989	Transcriptional Regulation by TP53
reactome	R-HSA-6791312	TP53 Regulates Transcription of Cell Cycle Genes
reactome	R-HSA-6804114	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
reactome	R-HSA-73857	RNA Polymerase II Transcription
reactome	R-HSA-74160	Gene expression (Transcription)

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD255	SB225002	6
iGMDRD889	Compound 7d-cis	3
iGMDRD270	Ciclosporin	3
iGMDRD474	Avrainvillamide	4

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GADD45A

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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