GADD45A
Summary: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| growth arrest and DNA damage inducible alpha | MIM:126335 | Ensembl:ENSG00000116717 | HGNC:HGNC:4095 | PA28510 | 1p31.3 |
GO terms in GADD45A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | IBA | GO:0000185 | activation of MAPKKK activity |
| BP | IDA | GO:0000185 | activation of MAPKKK activity |
| BP | TAS | GO:0006281 | DNA repair |
| BP | IEA | GO:0006469 | negative regulation of protein kinase activity |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | TAS | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| BP | TAS | GO:0007050 | cell cycle arrest |
| BP | IEA | GO:0007098 | centrosome cycle |
| BP | IMP | GO:0042770 | signal transduction in response to DNA damage |
| BP | IDA | GO:0043065 | positive regulation of apoptotic process |
| BP | IDA | GO:0046330 | positive regulation of JNK cascade |
| BP | IBA | GO:0051726 | regulation of cell cycle |
| BP | IEP | GO:0071260 | cellular response to mechanical stimulus |
| BP | IMP | GO:0071479 | cellular response to ionizing radiation |
| BP | IDA | GO:0071850 | mitotic cell cycle arrest |
| BP | IDA | GO:1900745 | positive regulation of p38MAPK cascade |
| BP | IMP | GO:2000379 | positive regulation of reactive oxygen species metabolic process |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0016607 | nuclear speck |
| MF | IEA | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019900 | kinase binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IPI | GO:0046982 | protein heterodimerization activity |
| MF | IDA | GO:0047485 | protein N-terminus binding |
Gene expression in normal tissue: GADD45A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GADD45A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes |
| reactome | R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| biocarta | atmpathway | atm signaling pathway |
| biocarta | g2pathway | cell cycle: g2/m checkpoint |
| biocarta | p53hypoxiapathway | hypoxia and p53 in the cardiovascular system |
| biocarta | p53pathway | p53 signaling pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa04115 | p53 signaling pathway - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| kegg | hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| kegg | hsa05213 | Endometrial cancer - Homo sapiens (human) |
| kegg | hsa05214 | Glioma - Homo sapiens (human) |
| kegg | hsa05216 | Thyroid cancer - Homo sapiens (human) |
| kegg | hsa05217 | Basal cell carcinoma - Homo sapiens (human) |
| kegg | hsa05218 | Melanoma - Homo sapiens (human) |
| kegg | hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
| pid | atf2_pathway | ATF-2 transcription factor network |
| pid | aurora_a_pathway | Aurora A signaling |
| pid | foxopathway | FoxO family signaling |
| pid | myc_represspathway | Validated targets of C-MYC transcriptional repression |
| pid | p38_mkk3_6pathway | p38 MAPK signaling pathway |
| pid | p53downstreampathway | Direct p53 effectors |
| pid | tap63pathway | Validated transcriptional targets of TAp63 isoforms |
| wikipathways | WP1530 | miRNA Regulation of DNA Damage Response |
| wikipathways | WP1742 | TP53 Network |
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP1984 | Integrated Breast Cancer Pathway |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP2516 | ATM Signaling Pathway |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| wikipathways | WP3640 | Imatinib and Chronic Myeloid Leukemia |
| wikipathways | WP3804 | TP53 Regulates Transcription of Cell Cycle Genes |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3941 | Oxidative Damage |
| wikipathways | WP4155 | Endometrial cancer |
| wikipathways | WP4216 | Chromosomal and microsatellite instability in colorectal cancer |
| wikipathways | WP45 | G1 to S cell cycle control |
| wikipathways | WP707 | DNA Damage Response |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD255 | SB225002 | 6 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD270 | Ciclosporin | 3 |
| iGMDRD474 | Avrainvillamide | 4 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD427 | ABT737 | 4 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD341 | Triacsin c | 1 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD286 | Nsc 632839 | 6 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD886 | Compound 1541A | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GADD45A
CLASSFICATION
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