Summary: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010].

growth arrest and DNA damage inducible alphaMIM:126335Ensembl:ENSG00000116717HGNC:HGNC:4095PA285101p31.3

GO terms in GADD45A

Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity
BPIBAGO:0000185activation of MAPKKK activity
BPIDAGO:0000185activation of MAPKKK activity
BPTASGO:0006281DNA repair
BPIEAGO:0006469negative regulation of protein kinase activity
BPTASGO:0006915apoptotic process
BPTASGO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
BPTASGO:0007050cell cycle arrest
BPIEAGO:0007098centrosome cycle
BPIMPGO:0042770signal transduction in response to DNA damage
BPIDAGO:0043065positive regulation of apoptotic process
BPIDAGO:0046330positive regulation of JNK cascade
BPIBAGO:0051726regulation of cell cycle
BPIEPGO:0071260cellular response to mechanical stimulus
BPIMPGO:0071479cellular response to ionizing radiation
BPIDAGO:0071850mitotic cell cycle arrest
BPIDAGO:1900745positive regulation of p38MAPK cascade
BPIMPGO:2000379positive regulation of reactive oxygen species metabolic process
CCIDAGO:0016607nuclear speck
MFIEAGO:0000979RNA polymerase II core promoter sequence-specific DNA binding
MFIPIGO:0005515protein binding
MFIPIGO:0019900kinase binding
MFIDAGO:0042803protein homodimerization activity
MFIPIGO:0046982protein heterodimerization activity
MFIDAGO:0047485protein N-terminus binding

Gene expression in normal tissue: GADD45A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GADD45A

DatabasePathway IDPathway Des.
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-6791312TP53 Regulates Transcription of Cell Cycle Genes
reactomeR-HSA-6804114TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
biocartaatmpathwayatm signaling pathway
biocartag2pathwaycell cycle: g2/m checkpoint
biocartap53hypoxiapathwayhypoxia and p53 in the cardiovascular system
biocartap53pathwayp53 signaling pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04110Cell cycle - Homo sapiens (human)
kegghsa04115p53 signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05213Endometrial cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05216Thyroid cancer - Homo sapiens (human)
kegghsa05217Basal cell carcinoma - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
pidatf2_pathwayATF-2 transcription factor network
pidaurora_a_pathwayAurora A signaling
pidfoxopathwayFoxO family signaling
pidmyc_represspathwayValidated targets of C-MYC transcriptional repression
pidp38_mkk3_6pathwayp38 MAPK signaling pathway
pidp53downstreampathwayDirect p53 effectors
pidtap63pathwayValidated transcriptional targets of TAp63 isoforms
wikipathwaysWP1530miRNA Regulation of DNA Damage Response
wikipathwaysWP1742TP53 Network
wikipathwaysWP179Cell Cycle
wikipathwaysWP1984Integrated Breast Cancer Pathway
wikipathwaysWP2431Spinal Cord Injury
wikipathwaysWP2516ATM Signaling Pathway
wikipathwaysWP2877Vitamin D Receptor Pathway
wikipathwaysWP3640Imatinib and Chronic Myeloid Leukemia
wikipathwaysWP3804TP53 Regulates Transcription of Cell Cycle Genes
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3941Oxidative Damage
wikipathwaysWP4155Endometrial cancer
wikipathwaysWP4216Chromosomal and microsatellite instability in colorectal cancer
wikipathwaysWP45G1 to S cell cycle control
wikipathwaysWP707DNA Damage Response

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD889Compound 7d-cis3
iGMDRD61Kinetin riboside1
iGMDRD341Triacsin c1
iGMDRD446LY 21832403
iGMDRD286Nsc 6328396
iGMDRD887Compound 23 citrate3
iGMDRD886Compound 1541A3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GADD45A