MAP2K7


Summary: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].

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GO terms in MAP2K7


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0000287 magnesium ion binding
MF IBA GO:0004674 protein serine/threonine kinase activity
MF IBA GO:0004708 MAP kinase kinase activity
MF IDA GO:0004708 MAP kinase kinase activity
MF IEA GO:0004713 protein tyrosine kinase activity
MF IPI GO:0005515 protein binding
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Gene expression in normal tissue: MAP2K7

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined18Cell cycle1Metabolism1Apoptosis regulation1ERK MAPK signaling1Other, kinases1

Pathways in MAP2K7


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Database
Pathway ID
Pathway Des.
netpath Pathway_EGFR1 EGFR1
netpath Pathway_IL1 IL1
kegg hsa04010 MAPK signaling pathway - Homo sapiens (human)
kegg hsa04012 ErbB signaling pathway - Homo sapiens (human)
kegg hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)
kegg hsa04380 Osteoclast differentiation - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD399 Selumetinib 2
iGMDRD414 MST-312 2
iGMDRD398 Sepantronium 2
iGMDRD506 Fedratinib 4
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAP2K7

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Model
Level
Reference ID
Tissue
Cancer
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Clinical Response
Source
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