MAP2K7
Summary: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitogen-activated protein kinase kinase 7 | MIM:603014 | Ensembl:ENSG00000076984 | HGNC:HGNC:6847 | PA284 | 19p13.2 |
GO terms in MAP2K7
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000287 | magnesium ion binding |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004708 | MAP kinase kinase activity |
| MF | IDA | GO:0004708 | MAP kinase kinase activity |
| MF | IEA | GO:0004713 | protein tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0008545 | JUN kinase kinase activity |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | ISS | GO:0019903 | protein phosphatase binding |
| BP | IBA | GO:0000187 | activation of MAPK activity |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IDA | GO:0006970 | response to osmotic stress |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0007257 | activation of JUN kinase activity |
| BP | ISS | GO:0007257 | activation of JUN kinase activity |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IDA | GO:0009408 | response to heat |
| BP | IDA | GO:0009411 | response to UV |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | IMP | GO:0032212 | positive regulation of telomere maintenance via telomerase |
| BP | IDA | GO:0034612 | response to tumor necrosis factor |
| BP | IDA | GO:0051403 | stress-activated MAPK cascade |
| BP | IMP | GO:0051973 | positive regulation of telomerase activity |
| BP | IMP | GO:1904355 | positive regulation of telomere capping |
| CC | ISS | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
Gene expression in normal tissue: MAP2K7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAP2K7
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_IL1 | IL1 |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2559580 | Oxidative Stress Induced Senescence |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-2871796 | FCERI mediated MAPK activation |
| reactome | R-HSA-448424 | Interleukin-17 signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-450294 | MAP kinase activation |
| reactome | R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| reactome | R-HSA-5210891 | Uptake and function of anthrax toxins |
| reactome | R-HSA-5339562 | Uptake and actions of bacterial toxins |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
| biocarta | fcer1pathway | fc epsilon receptor i signaling in mast cells |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| biocarta | mapkpathway | mapkinase signaling pathway |
| biocarta | stresspathway | tnf/stress related signaling |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA165985892 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| pid | anthraxpathway | Cellular roles of Anthrax toxin |
| pid | cdc42_pathway | CDC42 signaling events |
| pid | faspathway | FAS (CD95) signaling pathway |
| pid | fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| pid | hivnefpathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | rac1_pathway | RAC1 signaling pathway |
| pid | reelinpathway | Reelin signaling pathway |
| pid | tnfpathway | TNF receptor signaling pathway |
| smpdb | SMP00320 | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine |
| smpdb | SMP00321 | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine |
| smpdb | SMP00358 | Fc Epsilon Receptor I Signaling in Mast Cells |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP195 | IL-1 signaling pathway |
| wikipathways | WP2018 | RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP2637 | Structural Pathway of Interleukin 1 (IL-1) |
| wikipathways | WP2795 | Cardiac Hypertrophic Response |
| wikipathways | WP3611 | Photodynamic therapy-induced AP-1 survival signaling. |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3853 | ERK Pathway in Huntington,s Disease |
| wikipathways | WP3863 | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP422 | MAPK Cascade |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP673 | ErbB Signaling Pathway |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD506 | Fedratinib | 4 |
| iGMDRD640 | CAY10618 | 1 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD874 | BRD8958 | 1 |
| iGMDRD271 | Brefeldin A | 2 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 1 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD341 | Triacsin c | 1 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD61 | Kinetin riboside | 9 |
| iGMDRD351 | GW843682X | 5 |
| iGMDRD945 | ML214 | 1 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD427 | ABT737 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAP2K7
CLASSFICATION
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