Summary: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].

mitogen-activated protein kinase kinase 7MIM:603014Ensembl:ENSG00000076984HGNC:HGNC:6847PA28419p13.2

GO terms in MAP2K7

Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000287magnesium ion binding
MFIBAGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004708MAP kinase kinase activity
MFIDAGO:0004708MAP kinase kinase activity
MFIEAGO:0004713protein tyrosine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0008545JUN kinase kinase activity
MFIPIGO:0019899enzyme binding
MFIPIGO:0019901protein kinase binding
MFISSGO:0019903protein phosphatase binding
BPIBAGO:0000187activation of MAPK activity
BPIEAGO:0006915apoptotic process
BPIDAGO:0006970response to osmotic stress
BPTASGO:0007165signal transduction
BPIBAGO:0007257activation of JUN kinase activity
BPISSGO:0007257activation of JUN kinase activity
BPIBAGO:0007346regulation of mitotic cell cycle
BPIDAGO:0009408response to heat
BPIDAGO:0009411response to UV
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPIBAGO:0023014signal transduction by protein phosphorylation
BPIBAGO:0032147activation of protein kinase activity
BPIMPGO:0032212positive regulation of telomere maintenance via telomerase
BPIDAGO:0034612response to tumor necrosis factor
BPIDAGO:0051403stress-activated MAPK cascade
BPIMPGO:0051973positive regulation of telomerase activity
BPIMPGO:1904355positive regulation of telomere capping

Gene expression in normal tissue: MAP2K7

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAP2K7

DatabasePathway IDPathway Des.
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04141Protein processing in endoplasmic reticulum - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04530Tight junction - Homo sapiens (human)
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04664Fc epsilon RI signaling pathway - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04912GnRH signaling pathway - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166058MyD88:Mal cascade initiated on plasma membrane
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-168138Toll Like Receptor 9 (TLR9) Cascade
reactomeR-HSA-168142Toll Like Receptor 10 (TLR10) Cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168176Toll Like Receptor 5 (TLR5) Cascade
reactomeR-HSA-168179Toll Like Receptor TLR1:TLR2 Cascade
reactomeR-HSA-168181Toll Like Receptor 7/8 (TLR7/8) Cascade
reactomeR-HSA-168188Toll Like Receptor TLR6:TLR2 Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-181438Toll Like Receptor 2 (TLR2) Cascade
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2559580Oxidative Stress Induced Senescence
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-2871796FCERI mediated MAPK activation
reactomeR-HSA-448424Interleukin-17 signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-450294MAP kinase activation
reactomeR-HSA-450321JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
reactomeR-HSA-5210891Uptake and function of anthrax toxins
reactomeR-HSA-5339562Uptake and actions of bacterial toxins
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
reactomeR-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactomeR-HSA-975155MyD88 dependent cascade initiated on endosome
reactomeR-HSA-975871MyD88 cascade initiated on plasma membrane
biocartafcer1pathwayfc epsilon receptor i signaling in mast cells
biocartahivnefpathwayhiv-1 nef: negative effector of fas and tnf
biocartakeratinocytepathwaykeratinocyte differentiation
biocartamapkpathwaymapkinase signaling pathway
biocartastresspathwaytnf/stress related signaling
pharmgkbPA162356267EGFR Inhibitor Pathway, Pharmacodynamics
pharmgkbPA165985892Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
pharmgkbPA2032VEGF Signaling Pathway
pidanthraxpathwayCellular roles of Anthrax toxin
pidcdc42_pathwayCDC42 signaling events
pidfaspathwayFAS (CD95) signaling pathway
pidfcer1pathwayFc-epsilon receptor I signaling in mast cells
pidhivnefpathwayHIV-1 Nef: Negative effector of Fas and TNF-alpha
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidrac1_pathwayRAC1 signaling pathway
pidreelinpathwayReelin signaling pathway
pidtnfpathwayTNF receptor signaling pathway
smpdbSMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
smpdbSMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
smpdbSMP00358Fc Epsilon Receptor I Signaling in Mast Cells
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP195IL-1 signaling pathway
wikipathwaysWP2018RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP2637Structural Pathway of Interleukin 1 (IL-1)
wikipathwaysWP2795Cardiac Hypertrophic Response
wikipathwaysWP3611Photodynamic therapy-induced AP-1 survival signaling.
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3853ERK Pathway in Huntington,s Disease
wikipathwaysWP3863T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP422MAPK Cascade
wikipathwaysWP481Insulin Signaling
wikipathwaysWP673ErbB Signaling Pathway
wikipathwaysWP75Toll-like Receptor Signaling Pathway

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD322FK 8663
iGMDRD271Brefeldin A2
iGMDRD5Tyrphostin AG 14781
iGMDRD341Triacsin c1
iGMDRD61Kinetin riboside9
iGMDRD84Lovastatin acid3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAP2K7