MAP2K7
Summary: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:603014 Ensembl IDEnsembl:ENSG00000076984 HGNC IDHGNC:HGNC:6847 PHARMGKB IDPA284 Map Location19p13.2 |
GO terms in MAP2K7
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IDA | GO:0000287 | magnesium ion binding |
MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
MF | IBA | GO:0004708 | MAP kinase kinase activity |
MF | IDA | GO:0004708 | MAP kinase kinase activity |
MF | IEA | GO:0004713 | protein tyrosine kinase activity |
MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: MAP2K7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAP2K7
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Database | Pathway ID | Pathway Des. |
---|---|---|
netpath | Pathway_EGFR1 | EGFR1 |
netpath | Pathway_IL1 | IL1 |
kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in MAP2K7
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |