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BIRC6

Summary: This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
baculoviral IAP repeat containing 6	MIM:605638	Ensembl:ENSG00000115760	HGNC:HGNC:13516	PA25363	2p22.3

Gene Categories:

TUMOR SUPPRESSOR PROTEASE PROTEASE INHIBITOR DRUGGABLE GENOME

GO terms in BIRC6

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IDA	GO:0004842	ubiquitin-protein transferase activity
MF	IBA	GO:0004869	cysteine-type endopeptidase inhibitor activity
MF	IMP	GO:0004869	cysteine-type endopeptidase inhibitor activity
MF	IPI	GO:0005515	protein binding
MF	IBA	GO:0061631	ubiquitin conjugating enzyme activity
MF	IEA	GO:0061631	ubiquitin conjugating enzyme activity
BP	TAS	GO:0006468	protein phosphorylation
BP	IEA	GO:0006915	apoptotic process
BP	IEA	GO:0007049	cell cycle
BP	IEA	GO:0008284	positive regulation of cell proliferation
BP	IEA	GO:0010951	negative regulation of endopeptidase activity
BP	TAS	GO:0016567	protein ubiquitination
BP	IMP	GO:0032465	regulation of cytokinesis
BP	TAS	GO:0042127	regulation of cell proliferation
BP	IBA	GO:0043066	negative regulation of apoptotic process
BP	IMP	GO:0043066	negative regulation of apoptotic process
BP	TAS	GO:0043066	negative regulation of apoptotic process
BP	IEA	GO:0051301	cell division
BP	IEA	GO:0060711	labyrinthine layer development
BP	IEA	GO:0060712	spongiotrophoblast layer development
BP	IBA	GO:1990001	inhibition of cysteine-type endopeptidase activity involved in apoptotic process
BP	IMP	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway
CC	IDA	GO:0000922	spindle pole
CC	IBA	GO:0005634	nucleus
CC	IDA	GO:0005768	endosome
CC	IDA	GO:0005802	trans-Golgi network
CC	IDA	GO:0005815	microtubule organizing center
CC	HDA	GO:0016020	membrane
CC	IDA	GO:0030496	midbody
CC	IEA	GO:0090543	Flemming body

Gene expression in normal tissue: BIRC6

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BIRC6

Database	Pathway ID	Pathway Des.
kegg	hsa04120	Ubiquitin mediated proteolysis - Homo sapiens (human)
kegg	hsa04215	Apoptosis - multiple species - Homo sapiens (human)
wikipathways	WP1772	Apoptosis Modulation and Signaling

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD255	SB225002	2
iGMDRD613	CHEMBL258148	1
iGMDRD260	FQI-2	4
iGMDRD474	Avrainvillamide	6
iGMDRD138	PX 12	4
iGMDRD480	KU0060648	5
iGMDRD294	Batimastat	1
iGMDRD870	BRD63610	1
iGMDRD318	PAC-1	6
iGMDRD562	Navitoclax	3
iGMDRD506	Fedratinib	1
iGMDRD577	BIX01294	2
iGMDRD74	Idarubicin	2
iGMDRD188	Piperlongumine	4
iGMDRD100	Zebularine	1
iGMDRD64	Parbendazole	1
iGMDRD772	BRD4770	2
iGMDRD433	Lexibulin	1
iGMDRD151	CHM-1	3
iGMDRD76	Simvastatin	3
iGMDRD484	Pluripotin	3
iGMDRD546	BMS-754807	2
iGMDRD144	NSC95397	4
iGMDRD152	179324-69-7	2
iGMDRD639	YK 4-279	3
iGMDRD446	LY 2183240	2
iGMDRD280	CYTOCHALASIN B	1
iGMDRD297	Austocystin D	2
iGMDRD137	Indisulam	3
iGMDRD251	ML162	2
iGMDRD103	SN-38	4
iGMDRD213	SMR000068650	3
iGMDRD77	Itraconazole	3
iGMDRD289	Parthenolide	3
iGMDRD705	Nakiterpiosin	3
iGMDRD286	Nsc 632839	4
iGMDRD414	MST-312	4
iGMDRD246	NPC26	3
iGMDRD263	AACOCF3	2
iGMDRD505	Pevonedistat	6
iGMDRD148	Pifithrin-mu	2
iGMDRD512	nutlin 3	2
iGMDRD486	Tosedostat	3
iGMDRD424	Tamatinib	2
iGMDRD116	CD437	4
iGMDRD237	ABT-751	3
iGMDRD698	Neratinib	3
iGMDRD945	ML214	6
iGMDRD123	Isoevodiamine	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BIRC6

SITE

DATATYPES

CLASSFICATION

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