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NUMA1

Summary: This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
nuclear mitotic apparatus protein 1	MIM:164009	Ensembl:ENSG00000137497	HGNC:HGNC:8059	PA31844	11q13.4

Gene Categories:

TUMOR SUPPRESSOR

GO terms in NUMA1

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IBA	GO:0000132	establishment of mitotic spindle orientation
BP	IDA	GO:0000132	establishment of mitotic spindle orientation
BP	IMP	GO:0000132	establishment of mitotic spindle orientation
BP	ISS	GO:0000132	establishment of mitotic spindle orientation
BP	IMP	GO:0001578	microtubule bundle formation
BP	TAS	GO:0006997	nucleus organization
BP	IEA	GO:0007059	chromosome segregation
BP	ISS	GO:0030513	positive regulation of BMP signaling pathway
BP	IDA	GO:0030953	astral microtubule organization
BP	IMP	GO:0030953	astral microtubule organization
BP	IMP	GO:0031116	positive regulation of microtubule polymerization
BP	IMP	GO:0032388	positive regulation of intracellular transport
BP	ISS	GO:0045618	positive regulation of keratinocyte differentiation
BP	IEA	GO:0051301	cell division
BP	IEA	GO:0051321	meiotic cell cycle
BP	ISS	GO:0051798	positive regulation of hair follicle development
BP	IMP	GO:0051984	positive regulation of chromosome segregation
BP	IMP	GO:0055048	anastral spindle assembly
BP	IDA	GO:0060236	regulation of mitotic spindle organization
BP	IMP	GO:0060236	regulation of mitotic spindle organization
BP	IMP	GO:0090235	regulation of metaphase plate congression
BP	IDA	GO:1902365	positive regulation of protein localization to spindle pole body
BP	IMP	GO:1902846	positive regulation of mitotic spindle elongation
BP	IMP	GO:1904778	positive regulation of protein localization to cell cortex
BP	IMP	GO:1905820	positive regulation of chromosome separation
BP	IMP	GO:1905832	positive regulation of spindle assembly
CC	IEA	GO:0000139	Golgi membrane
CC	IBA	GO:0000922	spindle pole
CC	IDA	GO:0000922	spindle pole
CC	IDA	GO:0005634	nucleus
CC	IBA	GO:0005654	nucleoplasm
CC	IDA	GO:0005654	nucleoplasm
CC	TAS	GO:0005654	nucleoplasm
CC	IEA	GO:0005694	chromosome
CC	IBA	GO:0005737	cytoplasm
CC	IBA	GO:0005794	Golgi apparatus
CC	IBA	GO:0005813	centrosome
CC	IDA	GO:0005813	centrosome
CC	TAS	GO:0005819	spindle
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	IBA	GO:0005876	spindle microtubule
CC	IDA	GO:0005876	spindle microtubule
CC	IDA	GO:0005938	cell cortex
CC	IEA	GO:0016328	lateral plasma membrane
CC	IDA	GO:0016363	nuclear matrix
CC	IDA	GO:0019897	extrinsic component of plasma membrane
CC	IEA	GO:0030425	dendrite
CC	IDA	GO:0031616	spindle pole centrosome
CC	IDA	GO:0032991	protein-containing complex
CC	IMP	GO:0032991	protein-containing complex
CC	IDA	GO:0035371	microtubule plus-end
CC	IDA	GO:0036449	microtubule minus-end
CC	IEA	GO:0043025	neuronal cell body
CC	IDA	GO:0055028	cortical microtubule
CC	IDA	GO:0061673	mitotic spindle astral microtubule
CC	HDA	GO:0070062	extracellular exosome
CC	IDA	GO:0072686	mitotic spindle
CC	IDA	GO:0097427	microtubule bundle
CC	IDA	GO:0097431	mitotic spindle pole
CC	IMP	GO:0097431	mitotic spindle pole
CC	ISS	GO:0097575	lateral cell cortex
CC	IDA	GO:0099738	cell cortex region
CC	IDA	GO:1905720	cytoplasmic microtubule bundle
CC	IDA	GO:1990023	mitotic spindle midzone
MF	TAS	GO:0005198	structural molecule activity
MF	IPI	GO:0005515	protein binding
MF	IDA	GO:0008017	microtubule binding
MF	IMP	GO:0008022	protein C-terminus binding
MF	IDA	GO:0015631	tubulin binding
MF	IPI	GO:0019904	protein domain specific binding
MF	IDA	GO:0035091	phosphatidylinositol binding
MF	IDA	GO:0044877	protein-containing complex binding
MF	IDA	GO:0051010	microtubule plus-end binding
MF	IDA	GO:0051011	microtubule minus-end binding
MF	IDA	GO:0070840	dynein complex binding
MF	IMP	GO:0097718	disordered domain specific binding

Gene expression in normal tissue: NUMA1

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NUMA1

Database	Pathway ID	Pathway Des.
wikipathways	WP2858	Ectoderm Differentiation
pid	caspase_pathway	Caspase Cascade in Apoptosis
biocarta	hivnefpathway	hiv-1 nef: negative effector of fas and tnf
biocarta	ranmspathway	role of ran in mitotic spindle regulation
reactome	R-HSA-1640170	Cell Cycle
reactome	R-HSA-380320	Recruitment of NuMA to mitotic centrosomes
reactome	R-HSA-68875	Mitotic Prophase
reactome	R-HSA-68877	Mitotic Prometaphase
reactome	R-HSA-68886	M Phase
reactome	R-HSA-69278	Cell Cycle, Mitotic

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD446	LY 2183240	3
iGMDRD193	Fqi1	1
iGMDRD152	179324-69-7	2
iGMDRD280	CYTOCHALASIN B	2
iGMDRD394	BX-795	2
iGMDRD297	Austocystin D	4
iGMDRD151	CHM-1	2
iGMDRD889	Compound 7d-cis	2
iGMDRD781	Sirolimus	4
iGMDRD494	Neopeltolide	2
iGMDRD562	Navitoclax	3
iGMDRD780	PP-30	2
iGMDRD888	Compound 44	4
iGMDRD577	BIX01294	2
iGMDRD60	Quinoclamine	2
iGMDRD444	Tivantinib	2
iGMDRD874	BRD8958	3
iGMDRD474	Avrainvillamide	2
iGMDRD260	FQI-2	2
iGMDRD52	Rotenone	2
iGMDRD187	BRD9876	2
iGMDRD237	ABT-751	2
iGMDRD351	GW843682X	4
iGMDRD211	(1S,3R)-RSL3	2
iGMDRD132	(-)-gallocatechin-3-O-gallate	2
iGMDRD154	NSC23766	2
iGMDRD330	BRD4132	2
iGMDRD84	Lovastatin acid	3
iGMDRD116	CD437	4
iGMDRD67	PENFLURIDOL	2
iGMDRD414	MST-312	2
iGMDRD286	Nsc 632839	2
iGMDRD366	PI-103	3
iGMDRD300	Tozasertib	2
iGMDRD42	Vorinostat	2
iGMDRD158	NSC141540	2
iGMDRD434	BMS-536924	5
iGMDRD705	Nakiterpiosin	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NUMA1

SITE

DATATYPES

CLASSFICATION

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