NUMA1

Summary: This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namenuclear mitotic apparatus protein 1
OMIM IDMIM:164009
Ensembl IDEnsembl:ENSG00000137497
HGNC IDHGNC:HGNC:8059
PHARMGKB IDPA31844
Map Location11q13.4

Gene Categories:

TUMOR SUPPRESSOR

GO terms in NUMA1


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
BP IBA GO:0000132 establishment of mitotic spindle orientation
BP IDA GO:0000132 establishment of mitotic spindle orientation
BP IMP GO:0000132 establishment of mitotic spindle orientation
BP ISS GO:0000132 establishment of mitotic spindle orientation
BP IMP GO:0001578 microtubule bundle formation
BP TAS GO:0006997 nucleus organization
Showing 1 to 6 of 77 rows rows per page

Gene expression in normal tissue: NUMA1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NUMA1


Loading, please wait...
Database
Pathway ID
Pathway Des.
wikipathways WP2858 Ectoderm Differentiation
pid caspase_pathway Caspase Cascade in Apoptosis
biocarta hivnefpathway hiv-1 nef: negative effector of fas and tnf
biocarta ranmspathway role of ran in mitotic spindle regulation
reactome R-HSA-1640170 Cell Cycle
reactome R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
Showing 1 to 6 of 10 rows

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD446 LY 2183240 3
iGMDRD193 Fqi1 1
iGMDRD152 179324-69-7 2
iGMDRD280 CYTOCHALASIN B 2
Showing 1 to 4 of 38 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NUMA1

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.