B3GALT6

Summary: The enzyme encoded by this intronless gene is a beta-1,3-galactosyltransferase found in the medial Golgi apparatus, where it catalyzes the transfer of galactose from UDP-galactose to substrates containing a terminal beta-linked galactose moiety. The encoded enzyme has a particular affinity for galactose-beta-1,4-xylose found in the linker region of glycosamines. This enzyme is required for glycosaminoglycan synthesis. [provided by RefSeq, Jun 2013].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namebeta-1,3-galactosyltransferase 6
OMIM IDMIM:615291
Ensembl IDEnsembl:ENSG00000176022
HGNC IDHGNC:HGNC:17978
PHARMGKB IDPA25214
Map Location1p36.33

GO terms in B3GALT6


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0008378 galactosyltransferase activity
MF IEA GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
MF IBA GO:0016758 transferase activity, transferring hexosyl groups
MF IBA GO:0035250 UDP-galactosyltransferase activity
MF IDA GO:0035250 UDP-galactosyltransferase activity
MF TAS GO:0047220 galactosylxylosylprotein 3-beta-galactosyltransferase activity
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Gene expression in normal tissue: B3GALT6

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 24undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 3BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 4LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 17

Gene-drug pathway distribution

undefined17Apoptosis regulation1Longevity regulating pathway1PI3K/MTOR signaling1

Pathways in B3GALT6


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Database
Pathway ID
Pathway Des.
humancyc PWY-6557 glycoaminoglycan-protein linkage region biosynthesis
humancyc PWY-6564 heparan sulfate biosynthesis
humancyc PWY-6569 chondroitin sulfate biosynthesis
humancyc PWY-6571 dermatan sulfate biosynthesis
kegg hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate - Homo sapiens (human)
kegg hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD679 Bistramide A 2
iGMDRD394 BX-795 2
iGMDRD466 Chaetocin 2
iGMDRD280 CYTOCHALASIN B 6
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in B3GALT6

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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