AKAP4

Summary: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameA-kinase anchoring protein 4
OMIM IDMIM:300185
Ensembl IDEnsembl:ENSG00000147081
HGNC IDHGNC:HGNC:374
PHARMGKB IDPA24668
Map LocationXp11.22

GO terms in AKAP4


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0051018 protein kinase A binding
MF ISS GO:0051018 protein kinase A binding
CC HDA GO:0005634 nucleus
CC IBA GO:0005737 cytoplasm
CC TAS GO:0005856 cytoskeleton
CC NAS GO:0005952 cAMP-dependent protein kinase complex
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Gene expression in normal tissue: AKAP4

Gene-model tissue-cancer distribution: Bubble Plot

BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 10undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 44undefinedtissue: undefined cancer: SMALL_CELL_CARCINOMA model num: 2LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 9OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 8UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 2

Gene-drug pathway distribution

undefined23Cell cycle2Other, kinases1PI3K/MTOR signaling1Apoptosis regulation1

Pathways in AKAP4


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Database
Pathway ID
Pathway Des.
wikipathways WP35 G Protein Signaling Pathways
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD151 CHM-1 3
iGMDRD330 BRD4132 3
iGMDRD420 Leucascandrolide A 3
iGMDRD512 nutlin 3 6
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AKAP4

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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