AKAP4


Summary: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
A-kinase anchoring protein 4MIM:300185Ensembl:ENSG00000147081HGNC:HGNC:374PA24668Xp11.22

GO terms in AKAP4


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0051018protein kinase A binding
MFISSGO:0051018protein kinase A binding
CCHDAGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCTASGO:0005856cytoskeleton
CCNASGO:0005952cAMP-dependent protein kinase complex
CCIEAGO:0030018Z disc
CCIDAGO:0031514motile cilium
CCIBAGO:0035686sperm fibrous sheath
CCIEAGO:0048471perinuclear region of cytoplasm
CCIBAGO:0097228sperm principal piece
BPTASGO:0007165signal transduction
BPIEAGO:0007178transmembrane receptor protein serine/threonine kinase signaling pathway
BPTASGO:0007338single fertilization
BPIBAGO:0010738regulation of protein kinase A signaling
BPIMPGO:0030317flagellated sperm motility
BPIEAGO:0044458motile cilium assembly
BPIEAGO:0045184establishment of protein localization

Gene expression in normal tissue: AKAP4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AKAP4


DatabasePathway IDPathway Des.
wikipathwaysWP35G Protein Signaling Pathways

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD151CHM-13
iGMDRD330BRD41323
iGMDRD420Leucascandrolide A3
iGMDRD512nutlin 36
iGMDRD670ML 2103
iGMDRD427ABT7374
iGMDRD341Triacsin c2
iGMDRD446LY 21832402
iGMDRD351GW843682X1
iGMDRD280CYTOCHALASIN B3
iGMDRD679Bistramide A1
iGMDRD297Austocystin D2
iGMDRD435BI-25362
iGMDRD474Avrainvillamide1
iGMDRD434BMS-5369243
iGMDRD872BRD71372
iGMDRD188Piperlongumine1
iGMDRD286Nsc 6328397
iGMDRD871BRD63683
iGMDRD366PI-1033
iGMDRD780PP-301
iGMDRD562Navitoclax2
iGMDRD506Fedratinib4
iGMDRD329Merck603
iGMDRD246NPC263
iGMDRD263AACOCF33
iGMDRD552AZD-17752
iGMDRD886Compound 1541A2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AKAP4

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