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MYB

Summary: This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameMYB proto-oncogene, transcription factor OMIM IDMIM:189990 Ensembl IDEnsembl:ENSG00000118513 HGNC IDHGNC:HGNC:7545 PHARMGKB IDPA31345 Map Location6q23.3

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HISTONE MODIFICATION

GO terms in MYB

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	IMP	GO:0000122	negative regulation of transcription by RNA polymerase II
BP	IBA	GO:0000278	mitotic cell cycle
BP	IEA	GO:0001666	response to hypoxia
BP	IMP	GO:0006338	chromatin remodeling
BP	NAS	GO:0006355	regulation of transcription, DNA-templated
BP	IEA	GO:0006366	transcription by RNA polymerase II

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Gene expression in normal tissue: MYB

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MYB

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Database	Pathway ID	Pathway Des.
kegg	hsa04151	PI3K-Akt signaling pathway - Homo sapiens (human)
kegg	hsa05166	HTLV-I infection - Homo sapiens (human)
pid	ap1_pathway	AP-1 transcription factor network
pid	cmyb_pathway	C-MYB transcription factor network
pid	hes_heypathway	Notch-mediated HES/HEY network
pid	il2_pi3kpathway	IL2 signaling events mediated by PI3K

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD945	ML214	3
iGMDRD494	Neopeltolide	2
iGMDRD79	Gemcitabine	2
iGMDRD330	BRD4132	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MYB

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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