ELL
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| elongation factor for RNA polymerase II | MIM:600284 | Ensembl:ENSG00000105656 | HGNC:HGNC:23114 | PA134939610 | 19p13.11 |
GO terms in ELL
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0019902 | phosphatase binding |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0008023 | transcription elongation factor complex |
| CC | IDA | GO:0015030 | Cajal body |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | IDA | GO:0035327 | transcriptionally active chromatin |
| CC | IDA | GO:0035363 | histone locus body |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0006368 | transcription elongation from RNA polymerase II promoter |
| BP | IDA | GO:0010923 | negative regulation of phosphatase activity |
| BP | TAS | GO:0032786 | positive regulation of DNA-templated transcription, elongation |
| BP | IMP | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter |
| BP | IMP | GO:0042795 | snRNA transcription by RNA polymerase II |
| BP | TAS | GO:0042795 | snRNA transcription by RNA polymerase II |
| BP | IMP | GO:0042796 | snRNA transcription by RNA polymerase III |
| BP | IMP | GO:0045945 | positive regulation of transcription by RNA polymerase III |
Gene expression in normal tissue: ELL
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ELL
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112382 | Formation of RNA Pol II elongation complex |
| reactome | R-HSA-162587 | HIV Life Cycle |
| reactome | R-HSA-162599 | Late Phase of HIV Life Cycle |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat |
| reactome | R-HSA-167169 | HIV Transcription Elongation |
| reactome | R-HSA-167172 | Transcription of the HIV genome |
| reactome | R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat |
| reactome | R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation |
| reactome | R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery |
| reactome | R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript |
| reactome | R-HSA-167287 | HIV elongation arrest and recovery |
| reactome | R-HSA-167290 | Pausing and recovery of HIV elongation |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-5696398 | Nucleotide Excision Repair |
| reactome | R-HSA-674695 | RNA Polymerase II Pre-transcription Events |
| reactome | R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| reactome | R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes |
| reactome | R-HSA-6807505 | RNA polymerase II transcribes snRNA genes |
| reactome | R-HSA-6807505 | RNA polymerase II transcribes snRNA genes |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-75955 | RNA Polymerase II Transcription Elongation |
| wikipathways | WP2916 | Interactome of polycomb repressive complex 2 (PRC2) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD398 | Sepantronium | 1 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD494 | Neopeltolide | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ELL
CLASSFICATION
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