NCOA2
Summary: The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nuclear receptor coactivator 2 | MIM:601993 | Ensembl:ENSG00000140396 | HGNC:HGNC:7669 | PA31471 | 8q13.3 |
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in NCOA2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0016604 | nuclear body |
| CC | IMP | GO:0032991 | protein-containing complex |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | NAS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0010906 | regulation of glucose metabolic process |
| BP | TAS | GO:0015721 | bile acid and bile salt transport |
| BP | TAS | GO:0019216 | regulation of lipid metabolic process |
| BP | IEA | GO:0032570 | response to progesterone |
| BP | IBA | GO:0032870 | cellular response to hormone stimulus |
| BP | ISS | GO:0032922 | circadian regulation of gene expression |
| BP | IEA | GO:0045475 | locomotor rhythm |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:1904017 | cellular response to Thyroglobulin triiodothyronine |
| MF | IEA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding |
| MF | IEA | GO:0003682 | chromatin binding |
| MF | ISS | GO:0003713 | transcription coactivator activity |
| MF | NAS | GO:0003713 | transcription coactivator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0016922 | nuclear receptor binding |
| MF | IPI | GO:0016922 | nuclear receptor binding |
| MF | IPI | GO:0017162 | aryl hydrocarbon receptor binding |
| MF | IPI | GO:0019904 | protein domain specific binding |
| MF | IBA | GO:0030374 | nuclear receptor transcription coactivator activity |
| MF | IDA | GO:0030374 | nuclear receptor transcription coactivator activity |
| MF | IEA | GO:0030375 | thyroid hormone receptor coactivator activity |
| MF | IBA | GO:0035257 | nuclear hormone receptor binding |
| MF | IPI | GO:0035257 | nuclear hormone receptor binding |
| MF | IEA | GO:0046983 | protein dimerization activity |
Gene expression in normal tissue: NCOA2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NCOA2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2875 | Constitutive Androstane Receptor Pathway |
| wikipathways | WP2876 | Pregnane X Receptor pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP4010 | Liver steatosis AOP |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| pid | ar_pathway | Coregulation of Androgen receptor activity |
| pid | ar_tf_pathway | Regulation of Androgen receptor activity |
| pid | betacatenin_nuc_pathway | Regulation of nuclear beta catenin signaling and target gene transcription |
| pid | era_genomic_pathway | Validated nuclear estrogen receptor alpha network |
| pid | erb_genomic_pathway | Validated nuclear estrogen receptor beta network |
| pid | hif1_tfpathway | HIF-1-alpha transcription factor network |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| pid | retinoic_acid_pathway | Retinoic acid receptors-mediated signaling |
| pid | smad2_3nuclearpathway | Regulation of nuclear SMAD2/3 signaling |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| biocarta | ppargpathway | role of ppar-gamma coactivators in obesity and thermogenesis |
| biocarta | rarrxrpathway | nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1368082 | RORA activates gene expression |
| reactome | R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian gene expression |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1592230 | Mitochondrial biogenesis |
| reactome | R-HSA-159418 | Recycling of bile acids and salts |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-192105 | Synthesis of bile acids and bile salts |
| reactome | R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| reactome | R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol |
| reactome | R-HSA-194068 | Bile acid and bile salt metabolism |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-1989781 | PPARA activates gene expression |
| reactome | R-HSA-1989781 | PPARA activates gene expression |
| reactome | R-HSA-211859 | Biological oxidations |
| reactome | R-HSA-211897 | Cytochrome P450 - arranged by substrate type |
| reactome | R-HSA-211945 | Phase I - Functionalization of compounds |
| reactome | R-HSA-211976 | Endogenous sterols |
| reactome | R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis |
| reactome | R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3214847 | HATs acetylate histones |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| reactome | R-HSA-3899300 | SUMOylation of transcription cofactors |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-400206 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| reactome | R-HSA-400206 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| reactome | R-HSA-400253 | Circadian Clock |
| reactome | R-HSA-400253 | Circadian Clock |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-5625740 | RHO GTPases activate PKNs |
| reactome | R-HSA-5625886 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-8939211 | ESR-mediated signaling |
| reactome | R-HSA-8957322 | Metabolism of steroids |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| reactome | R-HSA-9018519 | Estrogen-dependent gene expression |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD886 | Compound 1541A | 4 |
| iGMDRD121 | GMX1778 | 4 |
| iGMDRD474 | Avrainvillamide | 5 |
| iGMDRD202 | Curcumin | 6 |
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD6 | AM-580 | 1 |
| iGMDRD314 | Tanespimycin | 1 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD330 | BRD4132 | 6 |
| iGMDRD523 | Cyanoquinoline, 11 | 1 |
| iGMDRD150 | RITA | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NCOA2
CLASSFICATION
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