TPR

Summary: This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nametranslocated promoter region, nuclear basket protein
OMIM IDMIM:189940
Ensembl IDEnsembl:ENSG00000047410
HGNC IDHGNC:HGNC:12017
PHARMGKB IDPA36696
Map Location1q31.1

GO terms in TPR


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0003682 chromatin binding
MF HDA GO:0003723 RNA binding
MF IDA GO:0003729 mRNA binding
MF IMP GO:0005215 transporter activity
MF IPI GO:0005515 protein binding
MF IDA GO:0015631 tubulin binding
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Gene expression in normal tissue: TPR

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined42Cell cycle2Stilbenoid, diarylheptanoid and gingerol biosynthesis1Metabolism1Chromatin other1Ferroptosis1Chromatin histone acetylation1Longevity regulating pathway1One carbon pool by folate1p53 pathway1

Pathways in TPR


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1169408 ISG15 antiviral mechanism
reactome R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes
reactome R-HSA-1280215 Cytokine Signaling in Immune system
reactome R-HSA-1430728 Metabolism
reactome R-HSA-159227 Transport of the SLBP independent Mature mRNA
reactome R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD187 BRD9876 3
iGMDRD171 Pemetrexed 2
iGMDRD260 FQI-2 3
iGMDRD138 PX 12 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TPR

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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