TPR
Summary: This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| translocated promoter region, nuclear basket protein | MIM:189940 | Ensembl:ENSG00000047410 | HGNC:HGNC:12017 | PA36696 | 1q31.1 |
GO terms in TPR
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0003682 | chromatin binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003729 | mRNA binding |
| MF | IMP | GO:0005215 | transporter activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0015631 | tubulin binding |
| MF | IDA | GO:0017056 | structural constituent of nuclear pore |
| MF | IDA | GO:0031072 | heat shock protein binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IMP | GO:0043495 | protein membrane anchor |
| MF | IDA | GO:0051019 | mitogen-activated protein kinase binding |
| MF | IDA | GO:0070840 | dynein complex binding |
| CC | IDA | GO:0000776 | kinetochore |
| CC | IDA | GO:0000776 | kinetochore |
| CC | IDA | GO:0000776 | kinetochore |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005635 | nuclear envelope |
| CC | IBA | GO:0005643 | nuclear pore |
| CC | IDA | GO:0005643 | nuclear pore |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005868 | cytoplasmic dynein complex |
| CC | IDA | GO:0019898 | extrinsic component of membrane |
| CC | IDA | GO:0031965 | nuclear membrane |
| CC | IDA | GO:0034399 | nuclear periphery |
| CC | IDA | GO:0042405 | nuclear inclusion body |
| CC | IDA | GO:0044615 | nuclear pore nuclear basket |
| CC | IDA | GO:0072686 | mitotic spindle |
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0006404 | RNA import into nucleus |
| BP | IMP | GO:0006405 | RNA export from nucleus |
| BP | TAS | GO:0006406 | mRNA export from nucleus |
| BP | IDA | GO:0006606 | protein import into nucleus |
| BP | IMP | GO:0006606 | protein import into nucleus |
| BP | IMP | GO:0006606 | protein import into nucleus |
| BP | IMP | GO:0006611 | protein export from nucleus |
| BP | IMP | GO:0006999 | nuclear pore organization |
| BP | IMP | GO:0006999 | nuclear pore organization |
| BP | IBA | GO:0007094 | mitotic spindle assembly checkpoint |
| BP | IMP | GO:0007094 | mitotic spindle assembly checkpoint |
| BP | IMP | GO:0010793 | regulation of mRNA export from nucleus |
| BP | IMP | GO:0010965 | regulation of mitotic sister chromatid separation |
| BP | TAS | GO:0016032 | viral process |
| BP | IMP | GO:0031453 | positive regulation of heterochromatin assembly |
| BP | IMP | GO:0031647 | regulation of protein stability |
| BP | IDA | GO:0031990 | mRNA export from nucleus in response to heat stress |
| BP | IDA | GO:0034605 | cellular response to heat |
| BP | ISS | GO:0035457 | cellular response to interferon-alpha |
| BP | IMP | GO:0042306 | regulation of protein import into nucleus |
| BP | IMP | GO:0042307 | positive regulation of protein import into nucleus |
| BP | IMP | GO:0043578 | nuclear matrix organization |
| BP | IMP | GO:0045947 | negative regulation of translational initiation |
| BP | IMP | GO:0046825 | regulation of protein export from nucleus |
| BP | ISS | GO:0046827 | positive regulation of protein export from nucleus |
| BP | IDA | GO:0046832 | negative regulation of RNA export from nucleus |
| BP | IMP | GO:0046832 | negative regulation of RNA export from nucleus |
| BP | IMP | GO:0051292 | nuclear pore complex assembly |
| BP | IEA | GO:0051301 | cell division |
| BP | IDA | GO:0070849 | response to epidermal growth factor |
| BP | IMP | GO:0090267 | positive regulation of mitotic cell cycle spindle assembly checkpoint |
| BP | IMP | GO:0090316 | positive regulation of intracellular protein transport |
| BP | IMP | GO:1901673 | regulation of mitotic spindle assembly |
Gene expression in normal tissue: TPR
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TPR
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1169408 | ISG15 antiviral mechanism |
| reactome | R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-159227 | Transport of the SLBP independent Mature mRNA |
| reactome | R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA |
| reactome | R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript |
| reactome | R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| reactome | R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| reactome | R-HSA-162587 | HIV Life Cycle |
| reactome | R-HSA-162599 | Late Phase of HIV Life Cycle |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162909 | Host Interactions of HIV factors |
| reactome | R-HSA-162909 | Host Interactions of HIV factors |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-165054 | Rev-mediated nuclear export of HIV RNA |
| reactome | R-HSA-168253 | Host Interactions with Influenza Factors |
| reactome | R-HSA-168254 | Influenza Infection |
| reactome | R-HSA-168255 | Influenza Life Cycle |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus |
| reactome | R-HSA-168273 | Influenza Viral RNA Transcription and Replication |
| reactome | R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus |
| reactome | R-HSA-168276 | NS1 Mediated Effects on Host Pathways |
| reactome | R-HSA-168325 | Viral Messenger RNA Synthesis |
| reactome | R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery |
| reactome | R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein |
| reactome | R-HSA-176033 | Interactions of Vpr with host cellular proteins |
| reactome | R-HSA-177243 | Interactions of Rev with host cellular proteins |
| reactome | R-HSA-177243 | Interactions of Rev with host cellular proteins |
| reactome | R-HSA-180746 | Nuclear import of Rev protein |
| reactome | R-HSA-180910 | Vpr-mediated nuclear import of PICs |
| reactome | R-HSA-191859 | snRNP Assembly |
| reactome | R-HSA-194441 | Metabolism of non-coding RNA |
| reactome | R-HSA-211000 | Gene Silencing by RNA |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2980766 | Nuclear Envelope Breakdown |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108214 | SUMOylation of DNA damage response and repair proteins |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3232142 | SUMOylation of ubiquitinylation proteins |
| reactome | R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly |
| reactome | R-HSA-3371453 | Regulation of HSF1-mediated heat shock response |
| reactome | R-HSA-3371556 | Cellular response to heat stress |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-4085377 | SUMOylation of SUMOylation proteins |
| reactome | R-HSA-4551638 | SUMOylation of chromatin organization proteins |
| reactome | R-HSA-4570464 | SUMOylation of RNA binding proteins |
| reactome | R-HSA-4615885 | SUMOylation of DNA replication proteins |
| reactome | R-HSA-4615885 | SUMOylation of DNA replication proteins |
| reactome | R-HSA-5578749 | Transcriptional regulation by small RNAs |
| reactome | R-HSA-5619102 | SLC transporter disorders |
| reactome | R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) |
| reactome | R-HSA-5619115 | Disorders of transmembrane transporters |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6784531 | tRNA processing in the nucleus |
| reactome | R-HSA-68875 | Mitotic Prophase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-70171 | Glycolysis |
| reactome | R-HSA-70326 | Glucose metabolism |
| reactome | R-HSA-71387 | Metabolism of carbohydrates |
| reactome | R-HSA-72202 | Transport of Mature Transcript to Cytoplasm |
| reactome | R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA |
| reactome | R-HSA-72306 | tRNA processing |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-913531 | Interferon Signaling |
| kegg | hsa03013 | RNA transport - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05216 | Thyroid cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD260 | FQI-2 | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD474 | Avrainvillamide | 7 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD506 | Fedratinib | 4 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD188 | Piperlongumine | 7 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD670 | ML 210 | 1 |
| iGMDRD427 | ABT737 | 5 |
| iGMDRD779 | PRL-3 Inhibitor I | 1 |
| iGMDRD599 | Salermide | 1 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD151 | CHM-1 | 4 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD639 | YK 4-279 | 1 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD446 | LY 2183240 | 5 |
| iGMDRD71 | Sparfosic acid | 3 |
| iGMDRD705 | Nakiterpiosin | 6 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 6 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD886 | Compound 1541A | 1 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD248 | BRD4354 | 1 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD435 | BI-2536 | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD901 | ELCPK | 1 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD351 | GW843682X | 4 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD85 | Ursolic acid | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TPR
CLASSFICATION
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