RNASE3

Summary: The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameribonuclease A family member 3
OMIM IDMIM:131398
Ensembl IDEnsembl:ENSG00000169397
HGNC IDHGNC:HGNC:10046
PHARMGKB IDPA34414
Map Location14q11.2

Gene Categories:

DRUGGABLE GENOME

GO terms in RNASE3


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0005576 extracellular region
CC IDA GO:0005615 extracellular space
CC TAS GO:0035578 azurophil granule lumen
BP IDA GO:0002227 innate immune response in mucosa
BP TAS GO:0006401 RNA catabolic process
BP TAS GO:0019730 antimicrobial humoral response
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Gene expression in normal tissue: RNASE3

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 33BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 6BONtissue: BON cancer: BONE model num: 0BONEtissue: BONE cancer: Osteosarcoma (OS) model num: 1SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: Cutaneous Melanoma (SKCM) model num: 3SKINtissue: SKIN cancer: Melanoma (MEL) model num: 6LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: Lung Adenocarcinoma (LUAD) model num: 1

Gene-drug pathway distribution

undefined17Apoptosis regulation2PI3K/MTOR signaling1Metabolic pathways1Mitosis1VEGF signaling pathway1

Pathways in RNASE3


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Database
Pathway ID
Pathway Des.
kegg hsa05310 Asthma - Homo sapiens (human)
reactome R-HSA-168249 Innate Immune System
reactome R-HSA-168256 Immune System
reactome R-HSA-6798695 Neutrophil degranulation
reactome R-HSA-6803157 Antimicrobial peptides
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD840 BRAF inhibitors in BRAF mutant tumor 3
iGMDRD577 BIX01294 2
iGMDRD562 Navitoclax 2
iGMDRD839 BRAF inhibitor 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RNASE3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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