RNASE3
Summary: The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ribonuclease A family member 3 | MIM:131398 | Ensembl:ENSG00000169397 | HGNC:HGNC:10046 | PA34414 | 14q11.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in RNASE3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005615 | extracellular space |
| CC | TAS | GO:0035578 | azurophil granule lumen |
| BP | IDA | GO:0002227 | innate immune response in mucosa |
| BP | TAS | GO:0006401 | RNA catabolic process |
| BP | TAS | GO:0019730 | antimicrobial humoral response |
| BP | IDA | GO:0019731 | antibacterial humoral response |
| BP | IDA | GO:0043152 | induction of bacterial agglutination |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IDA | GO:0045087 | innate immune response |
| BP | IDA | GO:0050829 | defense response to Gram-negative bacterium |
| BP | IDA | GO:0050830 | defense response to Gram-positive bacterium |
| BP | IDA | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide |
| BP | IEA | GO:0090501 | RNA phosphodiester bond hydrolysis |
| MF | IDA | GO:0001530 | lipopolysaccharide binding |
| MF | IEA | GO:0003676 | nucleic acid binding |
| MF | IBA | GO:0004519 | endonuclease activity |
| MF | IBA | GO:0004540 | ribonuclease activity |
| MF | TAS | GO:0004540 | ribonuclease activity |
Gene expression in normal tissue: RNASE3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RNASE3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05310 | Asthma - Homo sapiens (human) |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-6803157 | Antimicrobial peptides |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD840 | BRAF inhibitors in BRAF mutant tumor | 3 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD839 | BRAF inhibitor | 3 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD134 | Sorafenib | 3 |
| iGMDRD298 | L-685458 | 1 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD288 | Carboplatin | 1 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD499 | PDMP | 3 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD883 | CIL55A | 1 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD560 | MK-2206 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RNASE3
CLASSFICATION
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