NGF
Summary: This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nerve growth factor | MIM:162030 | Ensembl:ENSG00000134259 | HGNC:HGNC:7808 | PA162397475 | 1p13.2 |
GO terms in NGF
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | TAS | GO:0005768 | endosome |
| CC | TAS | GO:0005796 | Golgi lumen |
| CC | IBA | GO:0008021 | synaptic vesicle |
| CC | IBA | GO:0030424 | axon |
| CC | IBA | GO:0030425 | dendrite |
| CC | IBA | GO:0031410 | cytoplasmic vesicle |
| BP | TAS | GO:0000186 | activation of MAPKK activity |
| BP | TAS | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IBA | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | IBA | GO:0007267 | cell-cell signaling |
| BP | IBA | GO:0007422 | peripheral nervous system development |
| BP | IBA | GO:0007613 | memory |
| BP | TAS | GO:0008285 | negative regulation of cell proliferation |
| BP | IDA | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IMP | GO:0010628 | positive regulation of gene expression |
| BP | ISS | GO:0010628 | positive regulation of gene expression |
| BP | IBA | GO:0021675 | nerve development |
| BP | TAS | GO:0032455 | nerve growth factor processing |
| BP | IBA | GO:0038180 | nerve growth factor signaling pathway |
| BP | IBA | GO:0040011 | locomotion |
| BP | TAS | GO:0043065 | positive regulation of apoptotic process |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | TAS | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | TAS | GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | ISS | GO:0043388 | positive regulation of DNA binding |
| BP | IBA | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | IBA | GO:0045664 | regulation of neuron differentiation |
| BP | TAS | GO:0045666 | positive regulation of neuron differentiation |
| BP | ISS | GO:0046579 | positive regulation of Ras protein signal transduction |
| BP | TAS | GO:0048011 | neurotrophin TRK receptor signaling pathway |
| BP | TAS | GO:0048015 | phosphatidylinositol-mediated signaling |
| BP | IBA | GO:0048672 | positive regulation of collateral sprouting |
| BP | IBA | GO:0048812 | neuron projection morphogenesis |
| BP | IDA | GO:0048812 | neuron projection morphogenesis |
| BP | TAS | GO:0050772 | positive regulation of axonogenesis |
| BP | IBA | GO:0050804 | modulation of chemical synaptic transmission |
| MF | IBA | GO:0005163 | nerve growth factor receptor binding |
| MF | IPI | GO:0005163 | nerve growth factor receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008083 | growth factor activity |
| MF | IDA | GO:0008191 | metalloendopeptidase inhibitor activity |
Gene expression in normal tissue: NGF
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NGF
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-167021 | PLC-gamma1 signalling |
| reactome | R-HSA-167044 | Signalling to RAS |
| reactome | R-HSA-167060 | NGF processing |
| reactome | R-HSA-167060 | NGF processing |
| reactome | R-HSA-169893 | Prolonged ERK activation events |
| reactome | R-HSA-169893 | Prolonged ERK activation events |
| reactome | R-HSA-170968 | Frs2-mediated activation |
| reactome | R-HSA-170968 | Frs2-mediated activation |
| reactome | R-HSA-170984 | ARMS-mediated activation |
| reactome | R-HSA-170984 | ARMS-mediated activation |
| reactome | R-HSA-177504 | Retrograde neurotrophin signalling |
| reactome | R-HSA-177504 | Retrograde neurotrophin signalling |
| reactome | R-HSA-187015 | Activation of TRKA receptors |
| reactome | R-HSA-187015 | Activation of TRKA receptors |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-187042 | TRKA activation by NGF |
| reactome | R-HSA-187042 | TRKA activation by NGF |
| reactome | R-HSA-187687 | Signalling to ERKs |
| reactome | R-HSA-187687 | Signalling to ERKs |
| reactome | R-HSA-187706 | Signalling to p38 via RIT and RIN |
| reactome | R-HSA-193639 | p75NTR signals via NF-kB |
| reactome | R-HSA-193639 | p75NTR signals via NF-kB |
| reactome | R-HSA-193648 | NRAGE signals death through JNK |
| reactome | R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 |
| reactome | R-HSA-193681 | Ceramide signalling |
| reactome | R-HSA-193697 | p75NTR regulates axonogenesis |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-198203 | PI3K/AKT activation |
| reactome | R-HSA-198203 | PI3K/AKT activation |
| reactome | R-HSA-198745 | Signalling to STAT3 |
| reactome | R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE |
| reactome | R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE |
| reactome | R-HSA-205017 | NFG and proNGF binds to p75NTR |
| reactome | R-HSA-205025 | NADE modulates death signalling |
| reactome | R-HSA-205043 | NRIF signals cell death from the nucleus |
| reactome | R-HSA-205043 | NRIF signals cell death from the nucleus |
| reactome | R-HSA-209543 | p75NTR recruits signalling complexes |
| reactome | R-HSA-209543 | p75NTR recruits signalling complexes |
| reactome | R-HSA-209560 | NF-kB is activated and signals survival |
| reactome | R-HSA-209563 | Axonal growth stimulation |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9036866 | Expression and Processing of Neurotrophins |
| reactome | R-HSA-9036866 | Expression and Processing of Neurotrophins |
| biocarta | cdk5pathway | phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway |
| biocarta | erk5pathway | role of erk5 in neuronal survival pathway |
| biocarta | erkpathway | erk1/erk2 mapk signaling pathway |
| biocarta | ngfpathway | nerve growth factor pathway (ngf) |
| biocarta | trkapathway | trka receptor signaling pathway |
| netpath | Pathway_BDNF | BDNF |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| pid | pi3kplctrkpathway | Trk receptor signaling mediated by PI3K and PLC-gamma |
| pid | shp2_pathway | SHP2 signaling |
| pid | trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP3998 | Prader-Willi and Angelman Syndrome |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD42 | Vorinostat | 4 |
| iGMDRD577 | BIX01294 | 5 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD226 | ML006 | 2 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD251 | ML162 | 4 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD945 | ML214 | 5 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD2 | PK-11195 | 1 |
| iGMDRD341 | Triacsin c | 1 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD427 | ABT737 | 4 |
| iGMDRD150 | RITA | 2 |
| iGMDRD554 | CHEMBL1434137 | 2 |
| iGMDRD330 | BRD4132 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NGF
CLASSFICATION
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