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NGF

Summary: This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namenerve growth factor OMIM IDMIM:162030 Ensembl IDEnsembl:ENSG00000134259 HGNC IDHGNC:HGNC:7808 PHARMGKB IDPA162397475 Map Location1p13.2

Gene Categories:

GROWTH FACTOR DRUGGABLE GENOME PROTEASE INHIBITOR KINASE PROTEASE SERINE THREONINE KINASE NEUTRAL ZINC METALLOPEPTIDASE

GO terms in NGF

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	TAS	GO:0005576	extracellular region
CC	IBA	GO:0005615	extracellular space
CC	TAS	GO:0005768	endosome
CC	TAS	GO:0005796	Golgi lumen
CC	IBA	GO:0008021	synaptic vesicle
CC	IBA	GO:0030424	axon

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Gene expression in normal tissue: NGF

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NGF

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-166520	Signaling by NTRKs
reactome	R-HSA-166520	Signaling by NTRKs
reactome	R-HSA-167021	PLC-gamma1 signalling
reactome	R-HSA-167044	Signalling to RAS

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD524	ISX-9	2
iGMDRD42	Vorinostat	4
iGMDRD577	BIX01294	5
iGMDRD872	BRD7137	2

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NGF

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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