ITPR1


Summary: This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in ITPR1


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
MF ISS GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
MF TAS GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
MF IBA GO:0005509 calcium ion binding
MF IPI GO:0005515 protein binding
MF TAS GO:0015085 calcium ion transmembrane transporter activity
Showing 1 to 6 of 48 rows rows per page

Gene expression in normal tissue: ITPR1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 74undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 3undefinedtissue: undefined cancer: SMALL_CELL_CARCINOMA model num: 4LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 7BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 14UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 9

Gene-drug pathway distribution

undefined32DNA replication2Apoptosis regulation2Leukocyte transendothelial migration1Metabolism1PI3K/MTOR signaling1Chromatin histone acetylation1IGFR signaling1ERK MAPK signaling1One carbon pool by folate1

Pathways in ITPR1


Loading, please wait...
Database
Pathway ID
Pathway Des.
reactome R-HSA-109582 Hemostasis
reactome R-HSA-111885 Opioid Signalling
reactome R-HSA-112040 G-protein mediated events
reactome R-HSA-112043 PLC beta mediated events
reactome R-HSA-114508 Effects of PIP2 hydrolysis
reactome R-HSA-1280218 Adaptive Immune System
Showing 1 to 6 of 155 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD171 Pemetrexed 3
iGMDRD870 BRD63610 2
iGMDRD187 BRD9876 3
iGMDRD294 Batimastat 2
Showing 1 to 4 of 44 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ITPR1

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​