RALGDS
Summary: Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.[supplied by OMIM, Nov 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ral guanine nucleotide dissociation stimulator | MIM:601619 | Ensembl:ENSG00000160271 | HGNC:HGNC:9842 | PA34200 | 9q34.13-q34.2 |
GO terms in RALGDS
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0007265 | Ras protein signal transduction |
| BP | IEA | GO:0050790 | regulation of catalytic activity |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005903 | brush border |
| MF | IEA | GO:0005085 | guanyl-nucleotide exchange factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0030695 | GTPase regulator activity |
| MF | NAS | GO:0030695 | GTPase regulator activity |
Gene expression in normal tissue: RALGDS
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RALGDS
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2032 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| wikipathways | WP4216 | Chromosomal and microsatellite instability in colorectal cancer |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| kegg | hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| netpath | Pathway_EGFR1 | EGFR1 |
| biocarta | raspathway | ras signaling pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-167044 | Signalling to RAS |
| reactome | R-HSA-167044 | Signalling to RAS |
| reactome | R-HSA-171007 | p38MAPK events |
| reactome | R-HSA-171007 | p38MAPK events |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-187687 | Signalling to ERKs |
| reactome | R-HSA-187687 | Signalling to ERKs |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD269 | Purmorphamine | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD294 | Batimastat | 3 |
| iGMDRD415 | LE-135 | 3 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD513 | BML-259 | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 1 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD427 | ABT737 | 5 |
| iGMDRD144 | NSC95397 | 6 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD425 | ERASTIN | 3 |
| iGMDRD387 | CHIR-99021 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RALGDS
CLASSFICATION
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