IL21R


Summary: The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
interleukin 21 receptorMIM:605383Ensembl:ENSG00000103522HGNC:HGNC:6006PA2982116p12.1

Gene Categories:

DRUGGABLE GENOME

GO terms in IL21R


Term TypeEvidence TypeGO Term IDGO Des.
MFNASGO:0001532interleukin-21 receptor activity
CCTASGO:0005886plasma membrane
CCNASGO:0016021integral component of membrane
BPNASGO:0030101natural killer cell activation
BPTASGO:0038114interleukin-21-mediated signaling pathway

Gene expression in normal tissue: IL21R

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IL21R


DatabasePathway IDPathway Des.
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-451927Interleukin-2 family signaling
reactomeR-HSA-9020958Interleukin-21 signaling
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa05321Inflammatory bowel disease (IBD) - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD154NSC237665
iGMDRD211(1S,3R)-RSL33
iGMDRD57Chloropentafluorobenzene2
iGMDRD79Gemcitabine3
iGMDRD116CD4372
iGMDRD150RITA2
iGMDRD82Quiflapon2
iGMDRD300Tozasertib1
iGMDRD366PI-1032
iGMDRD414MST-3122
iGMDRD367Ro 28-16752
iGMDRD871BRD63682
iGMDRD6AM-5802
iGMDRD271Brefeldin A2
iGMDRD121GMX17782
iGMDRD297Austocystin D5
iGMDRD639YK 4-2793
iGMDRD494Neopeltolide2
iGMDRD427ABT7375
iGMDRD599Salermide2
iGMDRD420Leucascandrolide A2
iGMDRD554CHEMBL14341374
iGMDRD433Lexibulin2
iGMDRD23Gossypol2
iGMDRD60Quinoclamine2
iGMDRD577BIX012942
iGMDRD562Navitoclax4
iGMDRD399Selumetinib1
iGMDRD318PAC-11
iGMDRD870BRD636102
iGMDRD270Ciclosporin2
iGMDRD474Avrainvillamide3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IL21R

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