IL21R
Summary: The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| interleukin 21 receptor | MIM:605383 | Ensembl:ENSG00000103522 | HGNC:HGNC:6006 | PA29821 | 16p12.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in IL21R
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | NAS | GO:0001532 | interleukin-21 receptor activity |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | NAS | GO:0016021 | integral component of membrane |
| BP | NAS | GO:0030101 | natural killer cell activation |
| BP | TAS | GO:0038114 | interleukin-21-mediated signaling pathway |
Gene expression in normal tissue: IL21R
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IL21R
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-451927 | Interleukin-2 family signaling |
| reactome | R-HSA-9020958 | Interleukin-21 signaling |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa05321 | Inflammatory bowel disease (IBD) - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD154 | NSC23766 | 5 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD150 | RITA | 2 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD271 | Brefeldin A | 2 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD297 | Austocystin D | 5 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD427 | ABT737 | 5 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD554 | CHEMBL1434137 | 4 |
| iGMDRD433 | Lexibulin | 2 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD562 | Navitoclax | 4 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD474 | Avrainvillamide | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IL21R
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