GO terms in PPP3CA


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCIEAGO:0005739mitochondrion
CCIBAGO:0005829cytosol
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIBAGO:0005955calcineurin complex
CCIDAGO:0005955calcineurin complex
CCNASGO:0005955calcineurin complex
CCIDAGO:0009898cytoplasmic side of plasma membrane
CCIEAGO:0030018Z disc
CCIEAGO:0042383sarcolemma
CCIDAGO:0043197dendritic spine
BPIEAGO:0000082G1/S transition of mitotic cell cycle
BPIEAGO:0001975response to amphetamine
BPIDAGO:0006470protein dephosphorylation
BPIMPGO:0006470protein dephosphorylation
BPNASGO:0006470protein dephosphorylation
BPIEAGO:0006606protein import into nucleus
BPIEAGO:0006816calcium ion transport
BPTASGO:0007223Wnt signaling pathway, calcium modulating pathway
BPIEAGO:0014883transition between fast and slow fiber
BPIEAGO:0014898cardiac muscle hypertrophy in response to stress
BPTASGO:0016311dephosphorylation
BPIBAGO:0033173calcineurin-NFAT signaling cascade
BPIDAGO:0033173calcineurin-NFAT signaling cascade
BPIMPGO:0033173calcineurin-NFAT signaling cascade
BPIEAGO:0033555multicellular organismal response to stress
BPIEAGO:0035562negative regulation of chromatin binding
BPIDAGO:0035690cellular response to drug
BPTASGO:0038095Fc-epsilon receptor signaling pathway
BPTASGO:0042110T cell activation
BPIEAGO:0045807positive regulation of endocytosis
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0046676negative regulation of insulin secretion
BPIEAGO:0048741skeletal muscle fiber development
BPIEAGO:0050774negative regulation of dendrite morphogenesis
BPIEAGO:0050804modulation of chemical synaptic transmission
BPIEAGO:0051091positive regulation of DNA-binding transcription factor activity
BPIDAGO:0051592response to calcium ion
BPIEAGO:0060079excitatory postsynaptic potential
BPIEAGO:0070886positive regulation of calcineurin-NFAT signaling cascade
BPIEAGO:0071333cellular response to glucose stimulus
BPIBAGO:0097720calcineurin-mediated signaling
BPIEAGO:1903244positive regulation of cardiac muscle hypertrophy in response to stress
BPIEAGO:1903799negative regulation of production of miRNAs involved in gene silencing by miRNA
BPIEAGO:1905205positive regulation of connective tissue replacement
MFNASGO:0004722protein serine/threonine phosphatase activity
MFNASGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFIBAGO:0005516calmodulin binding
MFIDAGO:0005516calmodulin binding
MFNASGO:0005516calmodulin binding
MFIDAGO:0008144drug binding
MFIDAGO:0016018cyclosporin A binding
MFIDAGO:0019899enzyme binding
MFIBAGO:0033192calmodulin-dependent protein phosphatase activity
MFIDAGO:0033192calmodulin-dependent protein phosphatase activity
MFTASGO:0033192calmodulin-dependent protein phosphatase activity
MFIEAGO:0046982protein heterodimerization activity
MFIPIGO:0046983protein dimerization activity

Gene expression in normal tissue: PPP3CA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PPP3CA


DatabasePathway IDPathway Des.
pidbcr_5pathwayBCR signaling pathway
pidcmyb_pathwayC-MYB transcription factor network
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04114Oocyte meiosis - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
kegghsa04360Axon guidance - Homo sapiens (human)
kegghsa04370VEGF signaling pathway - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegghsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04662B cell receptor signaling pathway - Homo sapiens (human)
kegghsa04720Long-term potentiation - Homo sapiens (human)
kegghsa04724Glutamatergic synapse - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa04922Glucagon signaling pathway - Homo sapiens (human)
kegghsa04924Renin secretion - Homo sapiens (human)
kegghsa05010Alzheimer,s disease - Homo sapiens (human)
kegghsa05014Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human)
kegghsa05031Amphetamine addiction - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
pharmgkbPA165985892Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
wikipathwaysWP1528Physiological and Pathological Hypertrophy of the Heart
wikipathwaysWP1541Energy Metabolism
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2059Alzheimers Disease
wikipathwaysWP2431Spinal Cord Injury
wikipathwaysWP2447Amyotrophic lateral sclerosis (ALS)
wikipathwaysWP2583T-Cell Receptor and Co-stimulatory Signaling
wikipathwaysWP2795Cardiac Hypertrophic Response
wikipathwaysWP3414Initiation of transcription and translation elongation at the HIV-1 LTR
wikipathwaysWP35G Protein Signaling Pathways
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP391Mitochondrial Gene Expression
wikipathwaysWP3944Serotonin and anxiety-related events
wikipathwaysWP3947Serotonin and anxiety
wikipathwaysWP428Wnt Signaling Pathway
reactomeR-HSA-111885Opioid Signalling
reactomeR-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)
reactomeR-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-180024DARPP-32 events
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-2025928Calcineurin activates NFAT
reactomeR-HSA-2025928Calcineurin activates NFAT
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2871809FCERI mediated Ca+2 mobilization
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-3858494Beta-catenin independent WNT signaling
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-4086398Ca2+ pathway
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-5607763CLEC7A (Dectin-1) induces NFAT activation
reactomeR-HSA-5607764CLEC7A (Dectin-1) signaling
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
reactomeR-HSA-983705Signaling by the B Cell Receptor (BCR)
reactomeR-HSA-983705Signaling by the B Cell Receptor (BCR)
biocartabcrpathwaybcr signaling pathway
biocartacalcineurinpathwayeffects of calcineurin in keratinocyte differentiation
biocartack1pathwayregulation of ck1/cdk5 by type 1 glutamate receptors
biocartafmlppathwayfmlp induced chemokine gene expression in hmc-1 cells
biocartagpcrpathwaysignaling pathway from g-protein families
biocartamef2dpathwayrole of mef2d in t-cell apoptosis
biocartandkdynaminpathwayendocytotic role of ndk phosphins and dynamin
biocartanfatpathwaynfat and hypertrophy of the heart
biocartanos1pathwaynitric oxide signaling pathway
biocartapgc1apathwayregulation of pgc-1a
biocartatcrpathwayt cell receptor signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD289Parthenolide3
iGMDRD6AM-5803
iGMDRD434BMS-5369243
iGMDRD267Oligomycin A1
iGMDRD870BRD636101
iGMDRD474Avrainvillamide2
iGMDRD158NSC1415403
iGMDRD886Compound 1541A1
iGMDRD147Prima-13
iGMDRD60Quinoclamine5
iGMDRD268Cerulenin3
iGMDRD23Gossypol3
iGMDRD188Piperlongumine3
iGMDRD286Nsc 6328394
iGMDRD577BIX012941
iGMDRD506Fedratinib3
iGMDRD562Navitoclax4
iGMDRD398Sepantronium2
iGMDRD150RITA1
iGMDRD427ABT7373
iGMDRD424Tamatinib3
iGMDRD781Sirolimus5
iGMDRD126Tipifarnib2
iGMDRD307Manumycin A1
iGMDRD512nutlin 32
iGMDRD584VER 1550082
iGMDRD889Compound 7d-cis2
iGMDRD394BX-7956
iGMDRD280CYTOCHALASIN B2
iGMDRD341Triacsin c1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PPP3CA

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