NCKIPSD
Summary: The protein encoded by this gene is localized exclusively in the cell nucleus. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| NCK interacting protein with SH3 domain | MIM:606671 | Ensembl:ENSG00000213672 | HGNC:HGNC:15486 | PA134872724 | 3p21.31 |
GO terms in NCKIPSD
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006607 | NLS-bearing protein import into nucleus |
| BP | NAS | GO:0007010 | cytoskeleton organization |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0010976 | positive regulation of neuron projection development |
| BP | TAS | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| CC | TAS | GO:0005829 | cytosol |
| CC | NAS | GO:0005882 | intermediate filament |
| CC | IDA | GO:0008180 | COP9 signalosome |
| MF | IPI | GO:0005515 | protein binding |
| MF | NAS | GO:0008092 | cytoskeletal protein binding |
| MF | IEA | GO:0017124 | SH3 domain binding |
Gene expression in normal tissue: NCKIPSD
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NCKIPSD
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation |
| reactome | R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation |
| reactome | R-HSA-5663213 | RHO GTPases Activate WASPs and WAVEs |
| reactome | R-HSA-5663213 | RHO GTPases Activate WASPs and WAVEs |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD889 | Compound 7d-cis | 5 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD300 | Tozasertib | 6 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD318 | PAC-1 | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NCKIPSD
CLASSFICATION
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