MED13L
Summary: The protein encoded by this gene is a subunit of the Mediator complex, a large complex of proteins that functions as a transcriptional coactivator for most RNA polymerase II-transcribed genes. The encoded protein is involved in early development of the heart and brain. Defects in this gene are a cause of transposition of the great arteries, dextro-looped (DTGA).[provided by RefSeq, Jul 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mediator complex subunit 13 like | MIM:608771 | Ensembl:ENSG00000123066 | HGNC:HGNC:22962 | PA162395233 | 12q24.21 |
GO terms in MED13L
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| CC | IBA | GO:0016592 | mediator complex |
Gene expression in normal tissue: MED13L
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MED13L
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1989781 | PPARA activates gene expression |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| reactome | R-HSA-400206 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| reactome | R-HSA-556833 | Metabolism of lipids |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD705 | Nakiterpiosin | 7 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD886 | Compound 1541A | 6 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD414 | MST-312 | 6 |
| iGMDRD286 | Nsc 632839 | 6 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD532 | Olaparib | 2 |
| iGMDRD116 | CD437 | 1 |
| iGMDRD424 | Tamatinib | 4 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD260 | FQI-2 | 2 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD444 | Tivantinib | 2 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD100 | Zebularine | 1 |
| iGMDRD730 | Kahalalide F | 1 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD193 | Fqi1 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MED13L
CLASSFICATION
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