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TIMP3

Summary: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameTIMP metallopeptidase inhibitor 3 OMIM IDMIM:188826 Ensembl IDEnsembl:ENSG00000100234 HGNC IDHGNC:HGNC:11822 PHARMGKB IDPA36528 Map Location22q12.3

Gene Categories:

NEUTRAL ZINC METALLOPEPTIDASE PROTEASE PROTEASE INHIBITOR DRUGGABLE GENOME

GO terms in TIMP3

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	TAS	GO:0005576	extracellular region
CC	IEA	GO:0005604	basement membrane
CC	IBA	GO:0005615	extracellular space
CC	HDA	GO:0005634	nucleus
CC	TAS	GO:0031089	platelet dense granule lumen
CC	HDA	GO:0062023	collagen-containing extracellular matrix

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Gene expression in normal tissue: TIMP3

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TIMP3

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Database	Pathway ID	Pathway Des.
pharmgkb	PA2032	VEGF Signaling Pathway
kegg	hsa05205	Proteoglycans in cancer - Homo sapiens (human)
kegg	hsa05206	MicroRNAs in cancer - Homo sapiens (human)
wikipathways	WP129	Matrix Metalloproteinases
wikipathways	WP1539	Angiogenesis
wikipathways	WP2374	Oncostatin M Signaling Pathway

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD61	Kinetin riboside	1
iGMDRD446	LY 2183240	3
iGMDRD341	Triacsin c	3
iGMDRD375	GW-405833	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TIMP3

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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