TNRC6B
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| trinucleotide repeat containing 6B | MIM:610740 | Ensembl:ENSG00000100354 | HGNC:HGNC:29190 | PA134992981 | 22q13.1 |
GO terms in TNRC6B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0000932 | P-body |
| CC | TAS | GO:0005829 | cytosol |
| BP | TAS | GO:0007223 | Wnt signaling pathway, calcium modulating pathway |
| BP | IMP | GO:0031047 | gene silencing by RNA |
| BP | TAS | GO:0035194 | posttranscriptional gene silencing by RNA |
| BP | IEA | GO:0035278 | miRNA mediated inhibition of translation |
| BP | TAS | GO:0045652 | regulation of megakaryocyte differentiation |
| BP | IMP | GO:0060213 | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening |
| BP | IMP | GO:1900153 | positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: TNRC6B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TNRC6B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1912408 | Pre-NOTCH Transcription and Translation |
| reactome | R-HSA-1912422 | Pre-NOTCH Expression and Processing |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-211000 | Gene Silencing by RNA |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559580 | Oxidative Stress Induced Senescence |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-2559585 | Oncogene Induced Senescence |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-4086398 | Ca2+ pathway |
| reactome | R-HSA-426496 | Post-transcriptional silencing by small RNAs |
| reactome | R-HSA-5628897 | TP53 Regulates Metabolic Genes |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5687128 | MAPK6/MAPK4 signaling |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8934593 | Regulation of RUNX1 Expression and Activity |
| reactome | R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| reactome | R-HSA-8939211 | ESR-mediated signaling |
| reactome | R-HSA-8943723 | Regulation of PTEN mRNA translation |
| reactome | R-HSA-8948700 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| reactome | R-HSA-9018519 | Estrogen-dependent gene expression |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD6 | AM-580 | 2 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD77 | Itraconazole | 1 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD158 | NSC141540 | 6 |
| iGMDRD121 | GMX1778 | 1 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD251 | ML162 | 1 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD263 | AACOCF3 | 1 |
| iGMDRD42 | Vorinostat | 1 |
| iGMDRD322 | FK 866 | 5 |
| iGMDRD67 | PENFLURIDOL | 1 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD414 | MST-312 | 4 |
| iGMDRD329 | Merck60 | 6 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD299 | ICL 670 | 1 |
| iGMDRD79 | Gemcitabine | 4 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD330 | BRD4132 | 2 |
| iGMDRD307 | Manumycin A | 2 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD207 | Capsaicin | 1 |
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD270 | Ciclosporin | 1 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD802 | 4-methylfasudil | 2 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD268 | Cerulenin | 1 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD74 | Idarubicin | 4 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD546 | BMS-754807 | 4 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD433 | Lexibulin | 2 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD152 | 179324-69-7 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TNRC6B
CLASSFICATION
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