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IL1RAP

Summary: This gene encodes a component of the interleukin 1 receptor complex, which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in membrane-bound and soluble isoforms differing in their C-terminus. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Jul 2018].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameinterleukin 1 receptor accessory protein OMIM IDMIM:602626 Ensembl IDEnsembl:ENSG00000196083 HGNC IDHGNC:HGNC:5995 PHARMGKB IDPA29811 Map Location3q28

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DRUGGABLE GENOME

GO terms in IL1RAP

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IEA	GO:0002114	interleukin-33 receptor activity
MF	IEA	GO:0004908	interleukin-1 receptor activity
MF	IEA	GO:1990782	protein tyrosine kinase binding
BP	IEA	GO:0006954	inflammatory response
BP	TAS	GO:0006955	immune response
BP	TAS	GO:0019221	cytokine-mediated signaling pathway

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Gene expression in normal tissue: IL1RAP

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IL1RAP

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Database	Pathway ID	Pathway Des.
wikipathways	WP195	IL-1 signaling pathway
wikipathways	WP2637	Structural Pathway of Interleukin 1 (IL-1)
kegg	hsa04010	MAPK signaling pathway - Homo sapiens (human)
kegg	hsa04060	Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegg	hsa04659	Th17 cell differentiation - Homo sapiens (human)
kegg	hsa04750	Inflammatory mediator regulation of TRP channels - Homo sapiens (human)

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD132	(-)-gallocatechin-3-O-gallate	1
iGMDRD154	NSC23766	3
iGMDRD123	Isoevodiamine	3
iGMDRD219	Bax channel blocker	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IL1RAP

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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