IL1RAP
Summary: This gene encodes a component of the interleukin 1 receptor complex, which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in membrane-bound and soluble isoforms differing in their C-terminus. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Jul 2018].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| interleukin 1 receptor accessory protein | MIM:602626 | Ensembl:ENSG00000196083 | HGNC:HGNC:5995 | PA29811 | 3q28 |
Gene Categories:
DRUGGABLE GENOMEGO terms in IL1RAP
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0002114 | interleukin-33 receptor activity |
| MF | IEA | GO:0004908 | interleukin-1 receptor activity |
| MF | IEA | GO:1990782 | protein tyrosine kinase binding |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | TAS | GO:0006955 | immune response |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0032736 | positive regulation of interleukin-13 production |
| BP | IEA | GO:0032754 | positive regulation of interleukin-5 production |
| BP | TAS | GO:0038172 | interleukin-33-mediated signaling pathway |
| BP | IEA | GO:0042094 | interleukin-2 biosynthetic process |
| BP | IEA | GO:0045087 | innate immune response |
| BP | IEA | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | ISS | GO:0051965 | positive regulation of synapse assembly |
| BP | TAS | GO:0065003 | protein-containing complex assembly |
| BP | TAS | GO:0070498 | interleukin-1-mediated signaling pathway |
| BP | IEA | GO:0072602 | interleukin-4 secretion |
| BP | IEA | GO:1900006 | positive regulation of dendrite development |
| BP | IEA | GO:2000778 | positive regulation of interleukin-6 secretion |
| CC | IEA | GO:0005576 | extracellular region |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | HDA | GO:0016020 | membrane |
Gene expression in normal tissue: IL1RAP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IL1RAP
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP195 | IL-1 signaling pathway |
| wikipathways | WP2637 | Structural Pathway of Interleukin 1 (IL-1) |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| pid | il1pathway | IL1-mediated signaling events |
| pid | p73pathway | p73 transcription factor network |
| netpath | Pathway_IL1 | IL1 |
| biocarta | il1rpathway | signal transduction through il1r |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-388844 | Receptor-type tyrosine-protein phosphatases |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-6794362 | Protein-protein interactions at synapses |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9014826 | Interleukin-36 pathway |
| reactome | R-HSA-9014843 | Interleukin-33 signaling |
| reactome | R-HSA-9020702 | Interleukin-1 signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 1 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD85 | Ursolic acid | 4 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 5 |
| iGMDRD584 | VER 155008 | 1 |
| iGMDRD148 | Pifithrin-mu | 2 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD300 | Tozasertib | 7 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD5 | Tyrphostin AG 1478 | 1 |
| iGMDRD137 | Indisulam | 5 |
| iGMDRD158 | NSC141540 | 1 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD202 | Curcumin | 4 |
| iGMDRD634 | SCHEMBL2608041 | 4 |
| iGMDRD297 | Austocystin D | 1 |
| iGMDRD280 | CYTOCHALASIN B | 4 |
| iGMDRD718 | Pyrvinium pamoate | 2 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD451 | Serdemetan | 4 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD171 | Pemetrexed | 1 |
| iGMDRD474 | Avrainvillamide | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IL1RAP
CLASSFICATION
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