PRKCA
Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein kinase C alpha | MIM:176960 | Ensembl:ENSG00000154229 | HGNC:HGNC:9393 | PA33759 | 17q24.2 |
GO terms in PRKCA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | EXP | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | ISS | GO:0004697 | protein kinase C activity |
| MF | TAS | GO:0004697 | protein kinase C activity |
| MF | TAS | GO:0004698 | calcium-dependent protein kinase C activity |
| MF | ISS | GO:0005178 | integrin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IDA | GO:0019899 | enzyme binding |
| MF | IDA | GO:0035403 | histone kinase activity (H3-T6 specific) |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | IMP | GO:0001938 | positive regulation of endothelial cell proliferation |
| BP | IMP | GO:0002159 | desmosome assembly |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007077 | mitotic nuclear envelope disassembly |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | TAS | GO:0007411 | axon guidance |
| BP | IMP | GO:0010595 | positive regulation of endothelial cell migration |
| BP | ISS | GO:0010613 | positive regulation of cardiac muscle hypertrophy |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | TAS | GO:0018105 | peptidyl-serine phosphorylation |
| BP | ISS | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | TAS | GO:0030168 | platelet activation |
| BP | IMP | GO:0030335 | positive regulation of cell migration |
| BP | IMP | GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway |
| BP | IMP | GO:0034351 | negative regulation of glial cell apoptotic process |
| BP | IDA | GO:0035408 | histone H3-T6 phosphorylation |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | TAS | GO:0038128 | ERBB2 signaling pathway |
| BP | TAS | GO:0043488 | regulation of mRNA stability |
| BP | IDA | GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| BP | ISS | GO:0045651 | positive regulation of macrophage differentiation |
| BP | IMP | GO:0045766 | positive regulation of angiogenesis |
| BP | ISS | GO:0045780 | positive regulation of bone resorption |
| BP | IMP | GO:0045785 | positive regulation of cell adhesion |
| BP | IMP | GO:0045931 | positive regulation of mitotic cell cycle |
| BP | TAS | GO:0050796 | regulation of insulin secretion |
| BP | ISS | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IMP | GO:0070555 | response to interleukin-1 |
| BP | IDA | GO:0090330 | regulation of platelet aggregation |
| BP | TAS | GO:0097190 | apoptotic signaling pathway |
| BP | ISS | GO:0106071 | positive regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway |
| BP | ISS | GO:2000707 | positive regulation of dense core granule biogenesis |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | HDA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0031966 | mitochondrial membrane |
| CC | ISS | GO:0035866 | alphav-beta3 integrin-PKCalpha complex |
| CC | ISS | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: PRKCA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKCA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP00358 | Fc Epsilon Receptor I Signaling in Mast Cells |
| wikipathways | WP1471 | Target Of Rapamycin (TOR) Signaling |
| wikipathways | WP1993 | Angiogenesis overview |
| wikipathways | WP2012 | miRs in Muscle Cell Differentiation |
| wikipathways | WP2035 | Follicle Stimulating Hormone (FSH) signaling pathway |
| wikipathways | WP2038 | Regulation of Microtubule Cytoskeleton |
| wikipathways | WP2197 | Endothelin Pathways |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP2272 | Pathogenic Escherichia coli infection |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP244 | Alpha 6 Beta 4 signaling pathway |
| wikipathways | WP2583 | T-Cell Receptor and Co-stimulatory Signaling |
| wikipathways | WP2636 | Common Pathways Underlying Drug Addiction |
| wikipathways | WP2795 | Cardiac Hypertrophic Response |
| wikipathways | WP2806 | Human Complement System |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP3 | Transcriptional activation by NRF2 |
| wikipathways | WP304 | Kit receptor signaling pathway |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3298 | Melatonin metabolism and effects |
| wikipathways | WP35 | G Protein Signaling Pathways |
| wikipathways | WP363 | Wnt Signaling Pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3972 | PDGFR-beta pathway |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP428 | Wnt Signaling Pathway |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
| wikipathways | WP673 | ErbB Signaling Pathway |
| pid | a6b1_a6b4_integrin_pathway | a6b1 and a6b4 Integrin signaling |
| pid | atf2_pathway | ATF-2 transcription factor network |
| pid | cd8tcrdownstreampathway | Downstream signaling in naïve CD8+ T cells |
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | endothelinpathway | Endothelins |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | il8cxcr1_pathway | IL8- and CXCR1-mediated signaling events |
| pid | il8cxcr2_pathway | IL8- and CXCR2-mediated signaling events |
| pid | mtor_4pathway | mTOR signaling pathway |
| pid | nfat_3pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| pid | nfkappabcanonicalpathway | Canonical NF-kappaB pathway |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | ras_pathway | Regulation of Ras family activation |
| pid | ret_pathway | Signaling events regulated by Ret tyrosine kinase |
| pid | retinoic_acid_pathway | Retinoic acid receptors-mediated signaling |
| pid | syndecan_4_pathway | Syndecan-4-mediated signaling events |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| pid | tcrraspathway | Ras signaling in the CD4+ TCR pathway |
| pid | thrombin_par1_pathway | PAR1-mediated thrombin signaling events |
| pid | txa2pathway | Thromboxane A2 receptor signaling |
| pid | vegfr1_2_pathway | Signaling events mediated by VEGFR1 and VEGFR2 |
| pid | vegfr1_pathway | VEGFR1 specific signals |
| pharmgkb | PA152530845 | Proton Pump Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA2024 | Beta-agonist/Beta-blocker Pathway, Pharmacodynamics |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
| netpath | Pathway_CRH | CRH |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Gastrin | Gastrin |
| netpath | Pathway_Ghrelin | Ghrelin |
| netpath | Pathway_IL11 | IL11 |
| netpath | Pathway_IL3 | IL3 |
| netpath | Pathway_KitReceptor | KitReceptor |
| netpath | Pathway_TNFalpha | TNFalpha |
| netpath | Pathway_Wnt | Wnt |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| kegg | hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04540 | Gap junction - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
| kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| kegg | hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| kegg | hsa04713 | Circadian entrainment - Homo sapiens (human) |
| kegg | hsa04720 | Long-term potentiation - Homo sapiens (human) |
| kegg | hsa04723 | Retrograde endocannabinoid signaling - Homo sapiens (human) |
| kegg | hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
| kegg | hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| kegg | hsa04726 | Serotonergic synapse - Homo sapiens (human) |
| kegg | hsa04727 | GABAergic synapse - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| kegg | hsa04730 | Long-term depression - Homo sapiens (human) |
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| kegg | hsa04911 | Insulin secretion - Homo sapiens (human) |
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| kegg | hsa04916 | Melanogenesis - Homo sapiens (human) |
| kegg | hsa04918 | Thyroid hormone synthesis - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa04960 | Aldosterone-regulated sodium reabsorption - Homo sapiens (human) |
| kegg | hsa04961 | Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) |
| kegg | hsa04970 | Salivary secretion - Homo sapiens (human) |
| kegg | hsa04971 | Gastric acid secretion - Homo sapiens (human) |
| kegg | hsa04972 | Pancreatic secretion - Homo sapiens (human) |
| kegg | hsa05031 | Amphetamine addiction - Homo sapiens (human) |
| kegg | hsa05032 | Morphine addiction - Homo sapiens (human) |
| kegg | hsa05110 | Vibrio cholerae infection - Homo sapiens (human) |
| kegg | hsa05130 | Pathogenic Escherichia coli infection - Homo sapiens (human) |
| kegg | hsa05143 | African trypanosomiasis - Homo sapiens (human) |
| kegg | hsa05146 | Amoebiasis - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05214 | Glioma - Homo sapiens (human) |
| kegg | hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| biocarta | agpcrpathway | attenuation of gpcr signaling |
| biocarta | arenrf2pathway | oxidative stress induced gene expression via nrf2 |
| biocarta | at1rpathway | angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling |
| biocarta | bcrpathway | bcr signaling pathway |
| biocarta | biopeptidespathway | bioactive peptide induced signaling pathway |
| biocarta | calcineurinpathway | effects of calcineurin in keratinocyte differentiation |
| biocarta | cardiacegfpathway | role of egf receptor transactivation by gpcrs in cardiac hypertrophy |
| biocarta | cblpathway | cbl mediated ligand-induced downregulation of egf receptors pathway |
| biocarta | ccr3pathway | ccr3 signaling in eosinophils |
| biocarta | cdmacpathway | cadmium induces dna synthesis and proliferation in macrophages |
| biocarta | crebpathway | transcription factor creb and its extracellular signals |
| biocarta | edg1pathway | phospholipids as signalling intermediaries |
| biocarta | egfpathway | egf signaling pathway |
| biocarta | eif4pathway | regulation of eif-4e and p70s6 kinase |
| biocarta | erbb4pathway | g-secretase mediated erbb4 signaling pathway |
| biocarta | fmlppathway | fmlp induced chemokine gene expression in hmc-1 cells |
| biocarta | ghpathway | growth hormone signaling pathway |
| biocarta | gpcrpathway | signaling pathway from g-protein families |
| biocarta | ionpathway | ionomycin and phorbal ester signaling pathway |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| biocarta | mef2dpathway | role of mef2d in t-cell apoptosis |
| biocarta | myosinpathway | pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase |
| biocarta | nos1pathway | nitric oxide signaling pathway |
| biocarta | par1pathway | thrombin signaling and protease-activated receptors |
| biocarta | pdgfpathway | pdgf signaling pathway |
| biocarta | pkcpathway | activation of pkc through g-protein coupled receptors |
| biocarta | pparapathway | mechanism of gene regulation by peroxisome proliferators via ppara |
| biocarta | pyk2pathway | links between pyk2 and map kinases |
| biocarta | sppapathway | aspirin blocks signaling pathway involved in platelet activation |
| biocarta | tcrpathway | t cell receptor signaling pathway |
| biocarta | telpathway | telomeres telomerase cellular aging and immortality |
| biocarta | tpopathway | tpo signaling pathway |
| biocarta | trkapathway | trka receptor signaling pathway |
| biocarta | vegfpathway | vegf hypoxia and angiogenesis |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-111885 | Opioid Signalling |
| reactome | R-HSA-111933 | Calmodulin induced events |
| reactome | R-HSA-111996 | Ca-dependent events |
| reactome | R-HSA-111997 | CaM pathway |
| reactome | R-HSA-112040 | G-protein mediated events |
| reactome | R-HSA-112043 | PLC beta mediated events |
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-114516 | Disinhibition of SNARE formation |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1250196 | SHC1 events in ERBB2 signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1433557 | Signaling by SCF-KIT |
| reactome | R-HSA-1433559 | Regulation of KIT signaling |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1489509 | DAG and IP3 signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-163685 | Integration of energy metabolism |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-2179392 | EGFR Transactivation by Gastrin |
| reactome | R-HSA-2187338 | Visual phototransduction |
| reactome | R-HSA-2514856 | The phototransduction cascade |
| reactome | R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade |
| reactome | R-HSA-2980766 | Nuclear Envelope Breakdown |
| reactome | R-HSA-3000170 | Syndecan interactions |
| reactome | R-HSA-3000171 | Non-integrin membrane-ECM interactions |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-399719 | Trafficking of AMPA receptors |
| reactome | R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity |
| reactome | R-HSA-399997 | Acetylcholine regulates insulin secretion |
| reactome | R-HSA-4086398 | Ca2+ pathway |
| reactome | R-HSA-4086400 | PCP/CE pathway |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-418597 | G alpha (z) signalling events |
| reactome | R-HSA-422356 | Regulation of insulin secretion |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-4419969 | Depolymerisation of the Nuclear Lamina |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA |
| reactome | R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements |
| reactome | R-HSA-5099900 | WNT5A-dependent internalization of FZD4 |
| reactome | R-HSA-5218921 | VEGFR2 mediated cell proliferation |
| reactome | R-HSA-68875 | Mitotic Prophase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ |
| reactome | R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK |
| reactome | R-HSA-8853659 | RET signaling |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9010642 | ROBO receptors bind AKAP5 |
| reactome | R-HSA-9010642 | ROBO receptors bind AKAP5 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD61 | Kinetin riboside | 6 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD483 | SCH-529074 | 2 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD577 | BIX01294 | 5 |
| iGMDRD690 | PRIMA-1MET | 6 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD499 | PDMP | 1 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD351 | GW843682X | 5 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD945 | ML214 | 1 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD330 | BRD4132 | 2 |
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD414 | MST-312 | 1 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD147 | Prima-1 | 2 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD158 | NSC141540 | 6 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD77 | Itraconazole | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRKCA
CLASSFICATION
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