PRKCA


Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
protein kinase C alphaMIM:176960Ensembl:ENSG00000154229HGNC:HGNC:9393PA3375917q24.2

GO terms in PRKCA


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004672protein kinase activity
MFEXPGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFISSGO:0004697protein kinase C activity
MFTASGO:0004697protein kinase C activity
MFTASGO:0004698calcium-dependent protein kinase C activity
MFISSGO:0005178integrin binding
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0008270zinc ion binding
MFIDAGO:0019899enzyme binding
MFIDAGO:0035403histone kinase activity (H3-T6 specific)
BPIEAGO:0001525angiogenesis
BPIMPGO:0001938positive regulation of endothelial cell proliferation
BPIMPGO:0002159desmosome assembly
BPIDAGO:0006468protein phosphorylation
BPTASGO:0007077mitotic nuclear envelope disassembly
BPIEAGO:0007155cell adhesion
BPTASGO:0007411axon guidance
BPIMPGO:0010595positive regulation of endothelial cell migration
BPISSGO:0010613positive regulation of cardiac muscle hypertrophy
BPIBAGO:0018105peptidyl-serine phosphorylation
BPTASGO:0018105peptidyl-serine phosphorylation
BPISSGO:0018107peptidyl-threonine phosphorylation
BPTASGO:0030168platelet activation
BPIMPGO:0030335positive regulation of cell migration
BPIMPGO:0031666positive regulation of lipopolysaccharide-mediated signaling pathway
BPIMPGO:0034351negative regulation of glial cell apoptotic process
BPIDAGO:0035408histone H3-T6 phosphorylation
BPIBAGO:0035556intracellular signal transduction
BPTASGO:0038128ERBB2 signaling pathway
BPTASGO:0043488regulation of mRNA stability
BPIDAGO:0043536positive regulation of blood vessel endothelial cell migration
BPISSGO:0045651positive regulation of macrophage differentiation
BPIMPGO:0045766positive regulation of angiogenesis
BPISSGO:0045780positive regulation of bone resorption
BPIMPGO:0045785positive regulation of cell adhesion
BPIMPGO:0045931positive regulation of mitotic cell cycle
BPTASGO:0050796regulation of insulin secretion
BPISSGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIMPGO:0070555response to interleukin-1
BPIDAGO:0090330regulation of platelet aggregation
BPTASGO:0097190apoptotic signaling pathway
BPISSGO:0106071positive regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway
BPISSGO:2000707positive regulation of dense core granule biogenesis
CCTASGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCHDAGO:0005739mitochondrion
CCIDAGO:0005783endoplasmic reticulum
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIEAGO:0031966mitochondrial membrane
CCISSGO:0035866alphav-beta3 integrin-PKCalpha complex
CCISSGO:0048471perinuclear region of cytoplasm
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: PRKCA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRKCA


DatabasePathway IDPathway Des.
smpdbSMP00358Fc Epsilon Receptor I Signaling in Mast Cells
wikipathwaysWP1471Target Of Rapamycin (TOR) Signaling
wikipathwaysWP1993Angiogenesis overview
wikipathwaysWP2012miRs in Muscle Cell Differentiation
wikipathwaysWP2035Follicle Stimulating Hormone (FSH) signaling pathway
wikipathwaysWP2038Regulation of Microtubule Cytoskeleton
wikipathwaysWP2197Endothelin Pathways
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP2272Pathogenic Escherichia coli infection
wikipathwaysWP2324AGE-RAGE pathway
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
wikipathwaysWP2374Oncostatin M Signaling Pathway
wikipathwaysWP2431Spinal Cord Injury
wikipathwaysWP244Alpha 6 Beta 4 signaling pathway
wikipathwaysWP2583T-Cell Receptor and Co-stimulatory Signaling
wikipathwaysWP2636Common Pathways Underlying Drug Addiction
wikipathwaysWP2795Cardiac Hypertrophic Response
wikipathwaysWP2806Human Complement System
wikipathwaysWP289Myometrial Relaxation and Contraction Pathways
wikipathwaysWP3Transcriptional activation by NRF2
wikipathwaysWP304Kit receptor signaling pathway
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3298Melatonin metabolism and effects
wikipathwaysWP35G Protein Signaling Pathways
wikipathwaysWP363Wnt Signaling Pathway
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3972PDGFR-beta pathway
wikipathwaysWP399Wnt Signaling Pathway and Pluripotency
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4223Ras Signaling
wikipathwaysWP428Wnt Signaling Pathway
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP481Insulin Signaling
wikipathwaysWP536Calcium Regulation in the Cardiac Cell
wikipathwaysWP673ErbB Signaling Pathway
pida6b1_a6b4_integrin_pathwaya6b1 and a6b4 Integrin signaling
pidatf2_pathwayATF-2 transcription factor network
pidcd8tcrdownstreampathwayDownstream signaling in naïve CD8+ T cells
pidcd8tcrpathwayTCR signaling in naïve CD8+ T cells
pidendothelinpathwayEndothelins
piderbb1_downstream_pathwayErbB1 downstream signaling
pidil8cxcr1_pathwayIL8- and CXCR1-mediated signaling events
pidil8cxcr2_pathwayIL8- and CXCR2-mediated signaling events
pidmtor_4pathwaymTOR signaling pathway
pidnfat_3pathwayRole of Calcineurin-dependent NFAT signaling in lymphocytes
pidnfkappabcanonicalpathwayCanonical NF-kappaB pathway
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidras_pathwayRegulation of Ras family activation
pidret_pathwaySignaling events regulated by Ret tyrosine kinase
pidretinoic_acid_pathwayRetinoic acid receptors-mediated signaling
pidsyndecan_4_pathwaySyndecan-4-mediated signaling events
pidtcr_pathwayTCR signaling in naïve CD4+ T cells
pidtcrraspathwayRas signaling in the CD4+ TCR pathway
pidthrombin_par1_pathwayPAR1-mediated thrombin signaling events
pidtxa2pathwayThromboxane A2 receptor signaling
pidvegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
pidvegfr1_pathwayVEGFR1 specific signals
pharmgkbPA152530845Proton Pump Inhibitor Pathway, Pharmacodynamics
pharmgkbPA162356267EGFR Inhibitor Pathway, Pharmacodynamics
pharmgkbPA2024Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
pharmgkbPA2032VEGF Signaling Pathway
netpathPathway_Alpha6Beta4IntegrinAlpha6Beta4Integrin
netpathPathway_CRHCRH
netpathPathway_EGFR1EGFR1
netpathPathway_GastrinGastrin
netpathPathway_GhrelinGhrelin
netpathPathway_IL11IL11
netpathPathway_IL3IL3
netpathPathway_KitReceptorKitReceptor
netpathPathway_TNFalphaTNFalpha
netpathPathway_WntWnt
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
kegghsa04070Phosphatidylinositol signaling system - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04261Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
kegghsa04270Vascular smooth muscle contraction - Homo sapiens (human)
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
kegghsa04360Axon guidance - Homo sapiens (human)
kegghsa04370VEGF signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04540Gap junction - Homo sapiens (human)
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegghsa04664Fc epsilon RI signaling pathway - Homo sapiens (human)
kegghsa04666Fc gamma R-mediated phagocytosis - Homo sapiens (human)
kegghsa04670Leukocyte transendothelial migration - Homo sapiens (human)
kegghsa04713Circadian entrainment - Homo sapiens (human)
kegghsa04720Long-term potentiation - Homo sapiens (human)
kegghsa04723Retrograde endocannabinoid signaling - Homo sapiens (human)
kegghsa04724Glutamatergic synapse - Homo sapiens (human)
kegghsa04725Cholinergic synapse - Homo sapiens (human)
kegghsa04726Serotonergic synapse - Homo sapiens (human)
kegghsa04727GABAergic synapse - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa04730Long-term depression - Homo sapiens (human)
kegghsa04750Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
kegghsa04911Insulin secretion - Homo sapiens (human)
kegghsa04912GnRH signaling pathway - Homo sapiens (human)
kegghsa04916Melanogenesis - Homo sapiens (human)
kegghsa04918Thyroid hormone synthesis - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa04925Aldosterone synthesis and secretion - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa04960Aldosterone-regulated sodium reabsorption - Homo sapiens (human)
kegghsa04961Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human)
kegghsa04970Salivary secretion - Homo sapiens (human)
kegghsa04971Gastric acid secretion - Homo sapiens (human)
kegghsa04972Pancreatic secretion - Homo sapiens (human)
kegghsa05031Amphetamine addiction - Homo sapiens (human)
kegghsa05032Morphine addiction - Homo sapiens (human)
kegghsa05110Vibrio cholerae infection - Homo sapiens (human)
kegghsa05130Pathogenic Escherichia coli infection - Homo sapiens (human)
kegghsa05143African trypanosomiasis - Homo sapiens (human)
kegghsa05146Amoebiasis - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05231Choline metabolism in cancer - Homo sapiens (human)
biocartaagpcrpathwayattenuation of gpcr signaling
biocartaarenrf2pathwayoxidative stress induced gene expression via nrf2
biocartaat1rpathwayangiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling
biocartabcrpathwaybcr signaling pathway
biocartabiopeptidespathwaybioactive peptide induced signaling pathway
biocartacalcineurinpathwayeffects of calcineurin in keratinocyte differentiation
biocartacardiacegfpathwayrole of egf receptor transactivation by gpcrs in cardiac hypertrophy
biocartacblpathwaycbl mediated ligand-induced downregulation of egf receptors pathway
biocartaccr3pathwayccr3 signaling in eosinophils
biocartacdmacpathwaycadmium induces dna synthesis and proliferation in macrophages
biocartacrebpathwaytranscription factor creb and its extracellular signals
biocartaedg1pathwayphospholipids as signalling intermediaries
biocartaegfpathwayegf signaling pathway
biocartaeif4pathwayregulation of eif-4e and p70s6 kinase
biocartaerbb4pathwayg-secretase mediated erbb4 signaling pathway
biocartafmlppathwayfmlp induced chemokine gene expression in hmc-1 cells
biocartaghpathwaygrowth hormone signaling pathway
biocartagpcrpathwaysignaling pathway from g-protein families
biocartaionpathwayionomycin and phorbal ester signaling pathway
biocartakeratinocytepathwaykeratinocyte differentiation
biocartamef2dpathwayrole of mef2d in t-cell apoptosis
biocartamyosinpathwaypkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase
biocartanos1pathwaynitric oxide signaling pathway
biocartapar1pathwaythrombin signaling and protease-activated receptors
biocartapdgfpathwaypdgf signaling pathway
biocartapkcpathwayactivation of pkc through g-protein coupled receptors
biocartapparapathwaymechanism of gene regulation by peroxisome proliferators via ppara
biocartapyk2pathwaylinks between pyk2 and map kinases
biocartasppapathwayaspirin blocks signaling pathway involved in platelet activation
biocartatcrpathwayt cell receptor signaling pathway
biocartatelpathwaytelomeres telomerase cellular aging and immortality
biocartatpopathwaytpo signaling pathway
biocartatrkapathwaytrka receptor signaling pathway
biocartavegfpathwayvegf hypoxia and angiogenesis
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-111885Opioid Signalling
reactomeR-HSA-111933Calmodulin induced events
reactomeR-HSA-111996Ca-dependent events
reactomeR-HSA-111997CaM pathway
reactomeR-HSA-112040G-protein mediated events
reactomeR-HSA-112043PLC beta mediated events
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-114516Disinhibition of SNARE formation
reactomeR-HSA-1227986Signaling by ERBB2
reactomeR-HSA-1250196SHC1 events in ERBB2 signaling
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1433557Signaling by SCF-KIT
reactomeR-HSA-1433559Regulation of KIT signaling
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1489509DAG and IP3 signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-2179392EGFR Transactivation by Gastrin
reactomeR-HSA-2187338Visual phototransduction
reactomeR-HSA-2514856The phototransduction cascade
reactomeR-HSA-2514859Inactivation, recovery and regulation of the phototransduction cascade
reactomeR-HSA-2980766Nuclear Envelope Breakdown
reactomeR-HSA-3000170Syndecan interactions
reactomeR-HSA-3000171Non-integrin membrane-ECM interactions
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-376176Signaling by ROBO receptors
reactomeR-HSA-376176Signaling by ROBO receptors
reactomeR-HSA-3858494Beta-catenin independent WNT signaling
reactomeR-HSA-3858494Beta-catenin independent WNT signaling
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-399719Trafficking of AMPA receptors
reactomeR-HSA-399721Glutamate binding, activation of AMPA receptors and synaptic plasticity
reactomeR-HSA-399997Acetylcholine regulates insulin secretion
reactomeR-HSA-4086398Ca2+ pathway
reactomeR-HSA-4086400PCP/CE pathway
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-416993Trafficking of GluR2-containing AMPA receptors
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-418597G alpha (z) signalling events
reactomeR-HSA-422356Regulation of insulin secretion
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-4419969Depolymerisation of the Nuclear Lamina
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-450520HuR (ELAVL1) binds and stabilizes mRNA
reactomeR-HSA-450531Regulation of mRNA stability by proteins that bind AU-rich elements
reactomeR-HSA-5099900WNT5A-dependent internalization of FZD4
reactomeR-HSA-5218921VEGFR2 mediated cell proliferation
reactomeR-HSA-68875Mitotic Prophase
reactomeR-HSA-68886M Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76005Response to elevated platelet cytosolic Ca2+
reactomeR-HSA-881907Gastrin-CREB signalling pathway via PKC and MAPK
reactomeR-HSA-8853659RET signaling
reactomeR-HSA-8953854Metabolism of RNA
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9010642ROBO receptors bind AKAP5
reactomeR-HSA-9010642ROBO receptors bind AKAP5

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD446LY 21832403
iGMDRD61Kinetin riboside6
iGMDRD679Bistramide A2
iGMDRD280CYTOCHALASIN B5
iGMDRD394BX-7953
iGMDRD210AC556491
iGMDRD889Compound 7d-cis3
iGMDRD483SCH-5290742
iGMDRD494Neopeltolide3
iGMDRD506Fedratinib1
iGMDRD577BIX012945
iGMDRD690PRIMA-1MET6
iGMDRD268Cerulenin2
iGMDRD356PNU-746542
iGMDRD138PX 123
iGMDRD474Avrainvillamide2
iGMDRD8012,4-dideoxy-DC-45-A23
iGMDRD499PDMP1
iGMDRD314Tanespimycin3
iGMDRD351GW843682X5
iGMDRD57Chloropentafluorobenzene3
iGMDRD945ML2141
iGMDRD132(-)-gallocatechin-3-O-gallate2
iGMDRD154NSC237661
iGMDRD307Manumycin A3
iGMDRD330BRD41322
iGMDRD512nutlin 34
iGMDRD79Gemcitabine3
iGMDRD414MST-3121
iGMDRD871BRD63683
iGMDRD872BRD71373
iGMDRD366PI-1032
iGMDRD505Pevonedistat3
iGMDRD147Prima-12
iGMDRD137Indisulam3
iGMDRD158NSC1415406
iGMDRD6AM-5802
iGMDRD289Parthenolide2
iGMDRD434BMS-5369243
iGMDRD267Oligomycin A1
iGMDRD77Itraconazole2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRKCA

​​​​