INHBA


Summary: This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients. [provided by RefSeq, Aug 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
inhibin subunit beta AMIM:147290Ensembl:ENSG00000122641HGNC:HGNC:6066PA298777p14.1

GO terms in INHBA


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0000082G1/S transition of mitotic cell cycle
BPIGIGO:0001541ovarian follicle development
BPNASGO:0001541ovarian follicle development
BPIGIGO:0001942hair follicle development
BPIDAGO:0002244hematopoietic progenitor cell differentiation
BPIDAGO:0006357regulation of transcription by RNA polymerase II
BPTASGO:0006952defense response
BPIDAGO:0007050cell cycle arrest
BPTASGO:0007166cell surface receptor signaling pathway
BPTASGO:0007267cell-cell signaling
BPNASGO:0007399nervous system development
BPIDAGO:0008285negative regulation of cell proliferation
BPIGIGO:0008584male gonad development
BPTASGO:0009611response to wounding
BPIEAGO:0010469regulation of signaling receptor activity
BPIDAGO:0010628positive regulation of gene expression
BPIBAGO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation
BPIDAGO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation
BPIDAGO:0021773striatal medium spiny neuron differentiation
BPTASGO:0030154cell differentiation
BPNASGO:0030218erythrocyte differentiation
BPIDAGO:0030308negative regulation of cell growth
BPIDAGO:0032270positive regulation of cellular protein metabolic process
BPIDAGO:0032924activin receptor signaling pathway
BPIDAGO:0035987endodermal cell differentiation
BPTASGO:0042326negative regulation of phosphorylation
BPIGIGO:0042476odontogenesis
BPIDAGO:0042493response to drug
BPIDAGO:0042541hemoglobin biosynthetic process
BPIGIGO:0042701progesterone secretion
BPIBAGO:0042981regulation of apoptotic process
BPIBAGO:0043408regulation of MAPK cascade
BPTASGO:0045077negative regulation of interferon-gamma biosynthetic process
BPTASGO:0045578negative regulation of B cell differentiation
BPIDAGO:0045648positive regulation of erythrocyte differentiation
BPTASGO:0045650negative regulation of macrophage differentiation
BPIDAGO:0045786negative regulation of cell cycle
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIGIGO:0046880regulation of follicle-stimulating hormone secretion
BPTASGO:0046881positive regulation of follicle-stimulating hormone secretion
BPNASGO:0046882negative regulation of follicle-stimulating hormone secretion
BPIEAGO:0048333mesodermal cell differentiation
BPIBAGO:0048468cell development
BPIGIGO:0060021roof of mouth development
BPISSGO:0060279positive regulation of ovulation
BPIBAGO:0060395SMAD protein signal transduction
BPISSGO:0061029eyelid development in camera-type eye
BPIEAGO:0071372cellular response to follicle-stimulating hormone stimulus
BPIEAGO:0071397cellular response to cholesterol
BPIDAGO:0097154GABAergic neuron differentiation
BPIDAGO:0097191extrinsic apoptotic signaling pathway
BPIDAGO:2001241positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
CCIDAGO:0005576extracellular region
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCIDAGO:0043509activin A complex
CCIDAGO:0043512inhibin A complex
CCIEAGO:0048471perinuclear region of cytoplasm
MFIBAGO:0005125cytokine activity
MFIDAGO:0005125cytokine activity
MFIBAGO:0005160transforming growth factor beta receptor binding
MFTASGO:0005179hormone activity
MFIPIGO:0005515protein binding
MFTASGO:0008083growth factor activity
MFIPIGO:0017046peptide hormone binding
MFIEAGO:0034711inhibin binding
MFIPIGO:0042802identical protein binding
MFIEAGO:0046982protein heterodimerization activity
MFIPIGO:0070699type II activin receptor binding

Gene expression in normal tissue: INHBA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in INHBA


DatabasePathway IDPathway Des.
reactomeR-HSA-1502540Signaling by Activin
reactomeR-HSA-1502540Signaling by Activin
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-209822Glycoprotein hormones
reactomeR-HSA-209952Peptide hormone biosynthesis
reactomeR-HSA-2473224Antagonism of Activin by Follistatin
reactomeR-HSA-2980736Peptide hormone metabolism
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-9006936Signaling by TGF-beta family members
reactomeR-HSA-9006936Signaling by TGF-beta family members
wikipathwaysWP2406Cardiac Progenitor Differentiation
wikipathwaysWP2804Hair Follicle Development- Induction (Part 1 of 3)
wikipathwaysWP2848Differentiation Pathway
wikipathwaysWP2857Mesodermal Commitment Pathway
wikipathwaysWP560TGF-beta Receptor Signaling
wikipathwaysWP615Senescence and Autophagy in Cancer
pidalk1pathwayALK1 signaling events
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04350TGF-beta signaling pathway - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD84Lovastatin acid3
iGMDRD420Leucascandrolide A3
iGMDRD546BMS-7548073
iGMDRD781Sirolimus1
iGMDRD351GW843682X3
iGMDRD152179324-69-71
iGMDRD154NSC237663
iGMDRD103SN-383
iGMDRD474Avrainvillamide2
iGMDRD158NSC1415403
iGMDRD202Curcumin3
iGMDRD289Parthenolide3
iGMDRD207Capsaicin3
iGMDRD267Oligomycin A3
iGMDRD871BRD63682
iGMDRD577BIX012945
iGMDRD398Sepantronium5
iGMDRD886Compound 1541A3
iGMDRD369TGX-1153
iGMDRD42Vorinostat3
iGMDRD82Quiflapon3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in INHBA

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