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INHBA

Summary: This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients. [provided by RefSeq, Aug 2016].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameinhibin subunit beta A OMIM IDMIM:147290 Ensembl IDEnsembl:ENSG00000122641 HGNC IDHGNC:HGNC:6066 PHARMGKB IDPA29877 Map Location7p14.1

Gene Categories:

CLINICALLY ACTIONABLE TUMOR SUPPRESSOR DRUG RESISTANCE GROWTH FACTOR HORMONE ACTIVITY DRUGGABLE GENOME

GO terms in INHBA

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	IDA	GO:0000082	G1/S transition of mitotic cell cycle
BP	IGI	GO:0001541	ovarian follicle development
BP	NAS	GO:0001541	ovarian follicle development
BP	IGI	GO:0001942	hair follicle development
BP	IDA	GO:0002244	hematopoietic progenitor cell differentiation
BP	IDA	GO:0006357	regulation of transcription by RNA polymerase II

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Gene expression in normal tissue: INHBA

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in INHBA

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-1502540	Signaling by Activin
reactome	R-HSA-1502540	Signaling by Activin
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-209822	Glycoprotein hormones
reactome	R-HSA-209952	Peptide hormone biosynthesis

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD84	Lovastatin acid	3
iGMDRD420	Leucascandrolide A	3
iGMDRD546	BMS-754807	3
iGMDRD781	Sirolimus	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in INHBA

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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