INHBA
Summary: This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients. [provided by RefSeq, Aug 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| inhibin subunit beta A | MIM:147290 | Ensembl:ENSG00000122641 | HGNC:HGNC:6066 | PA29877 | 7p14.1 |
GO terms in INHBA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | IGI | GO:0001541 | ovarian follicle development |
| BP | NAS | GO:0001541 | ovarian follicle development |
| BP | IGI | GO:0001942 | hair follicle development |
| BP | IDA | GO:0002244 | hematopoietic progenitor cell differentiation |
| BP | IDA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006952 | defense response |
| BP | IDA | GO:0007050 | cell cycle arrest |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | TAS | GO:0007267 | cell-cell signaling |
| BP | NAS | GO:0007399 | nervous system development |
| BP | IDA | GO:0008285 | negative regulation of cell proliferation |
| BP | IGI | GO:0008584 | male gonad development |
| BP | TAS | GO:0009611 | response to wounding |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IDA | GO:0010628 | positive regulation of gene expression |
| BP | IBA | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| BP | IDA | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| BP | IDA | GO:0021773 | striatal medium spiny neuron differentiation |
| BP | TAS | GO:0030154 | cell differentiation |
| BP | NAS | GO:0030218 | erythrocyte differentiation |
| BP | IDA | GO:0030308 | negative regulation of cell growth |
| BP | IDA | GO:0032270 | positive regulation of cellular protein metabolic process |
| BP | IDA | GO:0032924 | activin receptor signaling pathway |
| BP | IDA | GO:0035987 | endodermal cell differentiation |
| BP | TAS | GO:0042326 | negative regulation of phosphorylation |
| BP | IGI | GO:0042476 | odontogenesis |
| BP | IDA | GO:0042493 | response to drug |
| BP | IDA | GO:0042541 | hemoglobin biosynthetic process |
| BP | IGI | GO:0042701 | progesterone secretion |
| BP | IBA | GO:0042981 | regulation of apoptotic process |
| BP | IBA | GO:0043408 | regulation of MAPK cascade |
| BP | TAS | GO:0045077 | negative regulation of interferon-gamma biosynthetic process |
| BP | TAS | GO:0045578 | negative regulation of B cell differentiation |
| BP | IDA | GO:0045648 | positive regulation of erythrocyte differentiation |
| BP | TAS | GO:0045650 | negative regulation of macrophage differentiation |
| BP | IDA | GO:0045786 | negative regulation of cell cycle |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IGI | GO:0046880 | regulation of follicle-stimulating hormone secretion |
| BP | TAS | GO:0046881 | positive regulation of follicle-stimulating hormone secretion |
| BP | NAS | GO:0046882 | negative regulation of follicle-stimulating hormone secretion |
| BP | IEA | GO:0048333 | mesodermal cell differentiation |
| BP | IBA | GO:0048468 | cell development |
| BP | IGI | GO:0060021 | roof of mouth development |
| BP | ISS | GO:0060279 | positive regulation of ovulation |
| BP | IBA | GO:0060395 | SMAD protein signal transduction |
| BP | ISS | GO:0061029 | eyelid development in camera-type eye |
| BP | IEA | GO:0071372 | cellular response to follicle-stimulating hormone stimulus |
| BP | IEA | GO:0071397 | cellular response to cholesterol |
| BP | IDA | GO:0097154 | GABAergic neuron differentiation |
| BP | IDA | GO:0097191 | extrinsic apoptotic signaling pathway |
| BP | IDA | GO:2001241 | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| CC | IDA | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IDA | GO:0043509 | activin A complex |
| CC | IDA | GO:0043512 | inhibin A complex |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| MF | IBA | GO:0005125 | cytokine activity |
| MF | IDA | GO:0005125 | cytokine activity |
| MF | IBA | GO:0005160 | transforming growth factor beta receptor binding |
| MF | TAS | GO:0005179 | hormone activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008083 | growth factor activity |
| MF | IPI | GO:0017046 | peptide hormone binding |
| MF | IEA | GO:0034711 | inhibin binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
| MF | IPI | GO:0070699 | type II activin receptor binding |
Gene expression in normal tissue: INHBA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in INHBA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1502540 | Signaling by Activin |
| reactome | R-HSA-1502540 | Signaling by Activin |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-209822 | Glycoprotein hormones |
| reactome | R-HSA-209952 | Peptide hormone biosynthesis |
| reactome | R-HSA-2473224 | Antagonism of Activin by Follistatin |
| reactome | R-HSA-2980736 | Peptide hormone metabolism |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
| wikipathways | WP2406 | Cardiac Progenitor Differentiation |
| wikipathways | WP2804 | Hair Follicle Development- Induction (Part 1 of 3) |
| wikipathways | WP2848 | Differentiation Pathway |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP560 | TGF-beta Receptor Signaling |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| pid | alk1pathway | ALK1 signaling events |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD207 | Capsaicin | 3 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD577 | BIX01294 | 5 |
| iGMDRD398 | Sepantronium | 5 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD82 | Quiflapon | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in INHBA
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.