CXXC1
Summary: This gene encodes a protein that functions as a transcriptional activator that binds specifically to non-methylated CpG motifs through its CXXC domain. The protein is a component of the SETD1 complex, regulates gene expression and is essential for vertebrate development. [provided by RefSeq, Sep 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| CXXC finger protein 1 | MIM:609150 | Ensembl:ENSG00000154832 | HGNC:HGNC:24343 | PA134908762 | 18q21.1 |
Gene Categories:
HISTONE MODIFICATIONGO terms in CXXC1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0000987 | proximal promoter sequence-specific DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IDA | GO:0042800 | histone methyltransferase activity (H3-K4 specific) |
| MF | IDA | GO:0045322 | unmethylated CpG binding |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005669 | transcription factor TFIID complex |
| CC | IDA | GO:0005829 | cytosol |
| CC | IEA | GO:0016363 | nuclear matrix |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | IDA | GO:0035097 | histone methyltransferase complex |
| CC | IDA | GO:0048188 | Set1C/COMPASS complex |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IDA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0036498 | IRE1-mediated unfolded protein response |
| BP | IBA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0051568 | histone H3-K4 methylation |
Gene expression in normal tissue: CXXC1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CXXC1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3472 | XBP1(S) activates chaperone genes |
| reactome | R-HSA-381038 | XBP1(S) activates chaperone genes |
| reactome | R-HSA-381070 | IRE1alpha activates chaperones |
| reactome | R-HSA-381119 | Unfolded Protein Response (UPR) |
| reactome | R-HSA-392499 | Metabolism of proteins |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD248 | BRD4354 | 3 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD23 | Gossypol | 6 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD782 | DC-45-A2 | 4 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD202 | Curcumin | 1 |
| iGMDRD271 | Brefeldin A | 6 |
| iGMDRD137 | Indisulam | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CXXC1
CLASSFICATION
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