CXXC1


Summary: This gene encodes a protein that functions as a transcriptional activator that binds specifically to non-methylated CpG motifs through its CXXC domain. The protein is a component of the SETD1 complex, regulates gene expression and is essential for vertebrate development. [provided by RefSeq, Sep 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
CXXC finger protein 1MIM:609150Ensembl:ENSG00000154832HGNC:HGNC:24343PA13490876218q21.1

Gene Categories:

HISTONE MODIFICATION

GO terms in CXXC1


Term TypeEvidence TypeGO Term IDGO Des.
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0000987proximal promoter sequence-specific DNA binding
MFIPIGO:0005515protein binding
MFIEAGO:0008270zinc ion binding
MFIDAGO:0042800histone methyltransferase activity (H3-K4 specific)
MFIDAGO:0045322unmethylated CpG binding
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIBAGO:0005669transcription factor TFIID complex
CCIDAGO:0005829cytosol
CCIEAGO:0016363nuclear matrix
CCIDAGO:0016607nuclear speck
CCIDAGO:0035097histone methyltransferase complex
CCIDAGO:0048188Set1C/COMPASS complex
BPIEAGO:0006351transcription, DNA-templated
BPIDAGO:0006355regulation of transcription, DNA-templated
BPIEAGO:0006357regulation of transcription by RNA polymerase II
BPTASGO:0036498IRE1-mediated unfolded protein response
BPIBAGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0051568histone H3-K4 methylation

Gene expression in normal tissue: CXXC1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CXXC1


DatabasePathway IDPathway Des.
wikipathwaysWP3472XBP1(S) activates chaperone genes
reactomeR-HSA-381038XBP1(S) activates chaperone genes
reactomeR-HSA-381070IRE1alpha activates chaperones
reactomeR-HSA-381119Unfolded Protein Response (UPR)
reactomeR-HSA-392499Metabolism of proteins

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD154NSC237663
iGMDRD211(1S,3R)-RSL33
iGMDRD560MK-22063
iGMDRD116CD4373
iGMDRD670ML 2103
iGMDRD144NSC953973
iGMDRD424Tamatinib3
iGMDRD420Leucascandrolide A3
iGMDRD248BRD43543
iGMDRD307Manumycin A3
iGMDRD330BRD41323
iGMDRD23Gossypol6
iGMDRD369TGX-1153
iGMDRD577BIX012946
iGMDRD506Fedratinib1
iGMDRD780PP-303
iGMDRD871BRD63683
iGMDRD414MST-3123
iGMDRD286Nsc 6328394
iGMDRD885Compound 1103
iGMDRD267Oligomycin A3
iGMDRD52Rotenone3
iGMDRD782DC-45-A24
iGMDRD434BMS-5369243
iGMDRD255SB2250023
iGMDRD103SN-383
iGMDRD474Avrainvillamide1
iGMDRD202Curcumin1
iGMDRD271Brefeldin A6
iGMDRD137Indisulam4

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CXXC1

​​​​