CXXC1


Summary: This gene encodes a protein that functions as a transcriptional activator that binds specifically to non-methylated CpG motifs through its CXXC domain. The protein is a component of the SETD1 complex, regulates gene expression and is essential for vertebrate development. [provided by RefSeq, Sep 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:609150
PHARMGKB IDPA134908762
Map Location18q21.1

Gene Categories:

HISTONE MODIFICATION

GO terms in CXXC1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF IEA GO:0000987 proximal promoter sequence-specific DNA binding
MF IPI GO:0005515 protein binding
MF IEA GO:0008270 zinc ion binding
MF IDA GO:0042800 histone methyltransferase activity (H3-K4 specific)
MF IDA GO:0045322 unmethylated CpG binding
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Gene expression in normal tissue: CXXC1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined23Biosynthesis of secondary metabolites2Stilbenoid, diarylheptanoid and gingerol biosynthesis1DNA replication1Other, kinases1Ferroptosis1PI3K/MTOR signaling1

Pathways in CXXC1


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Database
Pathway ID
Pathway Des.
wikipathways WP3472 XBP1(S) activates chaperone genes
reactome R-HSA-381038 XBP1(S) activates chaperone genes
reactome R-HSA-381070 IRE1alpha activates chaperones
reactome R-HSA-381119 Unfolded Protein Response (UPR)
reactome R-HSA-392499 Metabolism of proteins
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD154 NSC23766 3
iGMDRD211 (1S,3R)-RSL3 3
iGMDRD560 MK-2206 3
iGMDRD116 CD437 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CXXC1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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