CXXC1
Summary: This gene encodes a protein that functions as a transcriptional activator that binds specifically to non-methylated CpG motifs through its CXXC domain. The protein is a component of the SETD1 complex, regulates gene expression and is essential for vertebrate development. [provided by RefSeq, Sep 2015].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:609150 Ensembl IDEnsembl:ENSG00000154832 HGNC IDHGNC:HGNC:24343 PHARMGKB IDPA134908762 Map Location18q21.1 |
Gene Categories:
HISTONE MODIFICATIONGO terms in CXXC1
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
MF | IEA | GO:0000987 | proximal promoter sequence-specific DNA binding |
MF | IPI | GO:0005515 | protein binding |
MF | IEA | GO:0008270 | zinc ion binding |
MF | IDA | GO:0042800 | histone methyltransferase activity (H3-K4 specific) |
MF | IDA | GO:0045322 | unmethylated CpG binding |
Gene expression in normal tissue: CXXC1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CXXC1
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Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP3472 | XBP1(S) activates chaperone genes |
reactome | R-HSA-381038 | XBP1(S) activates chaperone genes |
reactome | R-HSA-381070 | IRE1alpha activates chaperones |
reactome | R-HSA-381119 | Unfolded Protein Response (UPR) |
reactome | R-HSA-392499 | Metabolism of proteins |
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Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in CXXC1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |