TNFAIP3

Summary: This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameTNF alpha induced protein 3
OMIM IDMIM:191163
Ensembl IDEnsembl:ENSG00000118503
HGNC IDHGNC:HGNC:11896
PHARMGKB IDPA36593
Map Location6q23.3

GO terms in TNFAIP3


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Term Type
Evidence Type
GO Term ID
GO Des.
BP ISS GO:0001922 B-1 B cell homeostasis
BP IDA GO:0002237 response to molecule of bacterial origin
BP ISS GO:0002634 regulation of germinal center formation
BP IEA GO:0002677 negative regulation of chronic inflammatory response
BP IEA GO:0006915 apoptotic process
BP IEA GO:0006954 inflammatory response
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Gene expression in normal tissue: TNFAIP3

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 37undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 50undefinedtissue: undefined cancer: SMALL_CELL_CARCINOMA model num: 3undefinedtissue: undefined cancer: LARGE_CELL_CARCINOMA model num: 3BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 10

Gene-drug pathway distribution

undefined29PI3K/MTOR signaling2DNA replication1Chromatin histone acetylation1Chromatin other1Stilbenoid, diarylheptanoid and gingerol biosynthesis1ERK MAPK signaling1Longevity regulating pathway1Proteasome1Other, kinases1

Pathways in TNFAIP3


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Database
Pathway ID
Pathway Des.
biocarta cd40pathway cd40l signaling pathway
biocarta tnfr2pathway tnfr2 signaling pathway
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-168249 Innate Immune System
reactome R-HSA-168256 Immune System
reactome R-HSA-168638 NOD1/2 Signaling Pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD1008 SR-II-138A 3
iGMDRD151 CHM-1 2
iGMDRD781 Sirolimus 1
iGMDRD144 NSC95397 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TNFAIP3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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