BTRC


Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
beta-transducin repeat containing E3 ubiquitin protein ligaseMIM:603482Ensembl:ENSG00000166167HGNC:HGNC:1144PA2546510q24.32

Gene Categories:

TUMOR SUPPRESSOR

GO terms in BTRC


Term TypeEvidence TypeGO Term IDGO Des.
MFEXPGO:0004842ubiquitin-protein transferase activity
MFIDAGO:0004842ubiquitin-protein transferase activity
MFTASGO:0004842ubiquitin-protein transferase activity
MFIPIGO:0005515protein binding
MFIDAGO:0008013beta-catenin binding
MFIEAGO:0016874ligase activity
MFIBAGO:0030515snoRNA binding
MFIEAGO:0045309protein phosphorylated amino acid binding
MFIEAGO:0046983protein dimerization activity
MFIDAGO:0061630ubiquitin protein ligase activity
BPTASGO:0000086G2/M transition of mitotic cell cycle
BPIDAGO:0000209protein polyubiquitination
BPIMPGO:0000209protein polyubiquitination
BPTASGO:0000209protein polyubiquitination
BPIBAGO:0000462maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BPISSGO:0006470protein dephosphorylation
BPIDAGO:0006511ubiquitin-dependent protein catabolic process
BPTASGO:0007165signal transduction
BPIEAGO:0016032viral process
BPTASGO:0016055Wnt signaling pathway
BPIDAGO:0016567protein ubiquitination
BPISSGO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
BPIMPGO:0031648protein destabilization
BPIEAGO:0033598mammary gland epithelial cell proliferation
BPTASGO:0038061NIK/NF-kappaB signaling
BPIDAGO:0042752regulation of circadian rhythm
BPISSGO:0042753positive regulation of circadian rhythm
BPIEAGO:0043122regulation of I-kappaB kinase/NF-kappaB signaling
BPIDAGO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process
BPTASGO:0043433negative regulation of DNA-binding transcription factor activity
BPTASGO:0043687post-translational protein modification
BPIMPGO:0045862positive regulation of proteolysis
BPTASGO:0045879negative regulation of smoothened signaling pathway
BPIMPGO:0045892negative regulation of transcription, DNA-templated
BPISSGO:0045893positive regulation of transcription, DNA-templated
BPIEAGO:0048511rhythmic process
BPTASGO:0051403stress-activated MAPK cascade
BPIEAGO:0051726regulation of cell cycle
BPIEAGO:0060444branching involved in mammary gland duct morphogenesis
BPICGO:0060828regulation of canonical Wnt signaling pathway
BPIEAGO:0061136regulation of proteasomal protein catabolic process
BPTASGO:0070498interleukin-1-mediated signaling pathway
BPIEAGO:0071407cellular response to organic cyclic compound
CCTASGO:0005654nucleoplasm
CCTASGO:0005829cytosol
CCIDAGO:0019005SCF ubiquitin ligase complex
CCIBAGO:0032040small-subunit processome
CCIBAGO:0034388Pwp2p-containing subcomplex of 90S preribosome

Gene expression in normal tissue: BTRC

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BTRC


DatabasePathway IDPathway Des.
kegghsa04114Oocyte meiosis - Homo sapiens (human)
kegghsa04120Ubiquitin mediated proteolysis - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
kegghsa04340Hedgehog signaling pathway - Homo sapiens (human)
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa04710Circadian rhythm - Homo sapiens (human)
kegghsa05131Shigellosis - Homo sapiens (human)
pidbetacatenin_deg_pathwayDegradation of beta catenin
pidbetacatenin_nuc_pathwayRegulation of nuclear beta catenin signaling and target gene transcription
pidhdac_classi_pathwaySignaling events mediated by HDAC Class I
pidhedgehog_glipathwayHedgehog signaling events mediated by Gli proteins
pidnfkappabalternativepathwayAlternative NF-kappaB pathway
pidnfkappabatypicalpathwayAtypical NF-kappaB pathway
pidnfkappabcanonicalpathwayCanonical NF-kappaB pathway
pidps1pathwayPresenilin action in Notch and Wnt signaling
pidtap63pathwayValidated transcriptional targets of TAp63 isoforms
netpathPathway_ProlactinProlactin
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
netpathPathway_TNFalphaTNFalpha
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP366TGF-beta Signaling Pathway
reactomeR-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)
reactomeR-HSA-1169091Activation of NF-kappaB in B cells
reactomeR-HSA-1170546Prolactin receptor signaling
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162906HIV Infection
reactomeR-HSA-162909Host Interactions of HIV factors
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1643685Disease
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166058MyD88:Mal cascade initiated on plasma membrane
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-168138Toll Like Receptor 9 (TLR9) Cascade
reactomeR-HSA-168142Toll Like Receptor 10 (TLR10) Cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168176Toll Like Receptor 5 (TLR5) Cascade
reactomeR-HSA-168179Toll Like Receptor TLR1:TLR2 Cascade
reactomeR-HSA-168181Toll Like Receptor 7/8 (TLR7/8) Cascade
reactomeR-HSA-168188Toll Like Receptor TLR6:TLR2 Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-174113SCF-beta-TrCP mediated degradation of Emi1
reactomeR-HSA-174143APC/C-mediated degradation of cell cycle proteins
reactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphase
reactomeR-HSA-180534Vpu mediated degradation of CD4
reactomeR-HSA-181438Toll Like Receptor 2 (TLR2) Cascade
reactomeR-HSA-195253Degradation of beta-catenin by the destruction complex
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-202403TCR signaling
reactomeR-HSA-202424Downstream TCR signaling
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2565942Regulation of PLK1 Activity at G2/M Transition
reactomeR-HSA-2871837FCERI mediated NF-kB activation
reactomeR-HSA-3769402Deactivation of the beta-catenin transactivating complex
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-400253Circadian Clock
reactomeR-HSA-446652Interleukin-1 family signaling
reactomeR-HSA-448424Interleukin-17 signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-450294MAP kinase activation
reactomeR-HSA-453274Mitotic G2-G2/M phases
reactomeR-HSA-453276Regulation of mitotic cell cycle
reactomeR-HSA-5358351Signaling by Hedgehog
reactomeR-HSA-5358351Signaling by Hedgehog
reactomeR-HSA-5607761Dectin-1 mediated noncanonical NF-kB signaling
reactomeR-HSA-5607764CLEC7A (Dectin-1) signaling
reactomeR-HSA-5610780Degradation of GLI1 by the proteasome
reactomeR-HSA-5610783Degradation of GLI2 by the proteasome
reactomeR-HSA-5610785GLI3 is processed to GLI3R by the proteasome
reactomeR-HSA-5610787Hedgehog 'off' state
reactomeR-HSA-5610787Hedgehog 'off' state
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-5668541TNFR2 non-canonical NF-kB pathway
reactomeR-HSA-5676590NIK-->noncanonical NF-kB signaling
reactomeR-HSA-5684264MAP3K8 (TPL2)-dependent MAPK1/3 activation
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-69275G2/M Transition
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-8951664Neddylation
reactomeR-HSA-9020702Interleukin-1 signaling
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
reactomeR-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactomeR-HSA-975155MyD88 dependent cascade initiated on endosome
reactomeR-HSA-975871MyD88 cascade initiated on plasma membrane
reactomeR-HSA-983168Antigen processing: Ubiquitination & Proteasome degradation
reactomeR-HSA-983169Class I MHC mediated antigen processing & presentation
reactomeR-HSA-983705Signaling by the B Cell Receptor (BCR)
biocartagsk3pathwayinactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages
biocartawntpathwaywnt signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD100Zebularine3
iGMDRD188Piperlongumine7
iGMDRD888Compound 446
iGMDRD60Quinoclamine8
iGMDRD524ISX-91
iGMDRD23Gossypol2
iGMDRD474Avrainvillamide2
iGMDRD255SB2250025
iGMDRD52Rotenone4
iGMDRD187BRD98764
iGMDRD318PAC-16
iGMDRD446LY 21832406
iGMDRD61Kinetin riboside4
iGMDRD193Fqi13
iGMDRD316N9-Isopropyl-olomoucine2
iGMDRD1008SR-II-138A2
iGMDRD420Leucascandrolide A2
iGMDRD599Salermide3
iGMDRD781Sirolimus3
iGMDRD494Neopeltolide4
iGMDRD872BRD71373
iGMDRD286Nsc 6328392
iGMDRD414MST-3122
iGMDRD263AACOCF32
iGMDRD246NPC263
iGMDRD300Tozasertib3
iGMDRD505Pevonedistat6
iGMDRD322FK 8662
iGMDRD121GMX17782
iGMDRD289Parthenolide3
iGMDRD341Triacsin c3
iGMDRD123Isoevodiamine3
iGMDRD330BRD41325
iGMDRD248BRD43543
iGMDRD560MK-22063
iGMDRD150RITA6

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BTRC

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