BTRC
Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| beta-transducin repeat containing E3 ubiquitin protein ligase | MIM:603482 | Ensembl:ENSG00000166167 | HGNC:HGNC:1144 | PA25465 | 10q24.32 |
Gene Categories:
TUMOR SUPPRESSORGO terms in BTRC
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | EXP | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IDA | GO:0004842 | ubiquitin-protein transferase activity |
| MF | TAS | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008013 | beta-catenin binding |
| MF | IEA | GO:0016874 | ligase activity |
| MF | IBA | GO:0030515 | snoRNA binding |
| MF | IEA | GO:0045309 | protein phosphorylated amino acid binding |
| MF | IEA | GO:0046983 | protein dimerization activity |
| MF | IDA | GO:0061630 | ubiquitin protein ligase activity |
| BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | IDA | GO:0000209 | protein polyubiquitination |
| BP | IMP | GO:0000209 | protein polyubiquitination |
| BP | TAS | GO:0000209 | protein polyubiquitination |
| BP | IBA | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| BP | ISS | GO:0006470 | protein dephosphorylation |
| BP | IDA | GO:0006511 | ubiquitin-dependent protein catabolic process |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0016032 | viral process |
| BP | TAS | GO:0016055 | Wnt signaling pathway |
| BP | IDA | GO:0016567 | protein ubiquitination |
| BP | ISS | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
| BP | IMP | GO:0031648 | protein destabilization |
| BP | IEA | GO:0033598 | mammary gland epithelial cell proliferation |
| BP | TAS | GO:0038061 | NIK/NF-kappaB signaling |
| BP | IDA | GO:0042752 | regulation of circadian rhythm |
| BP | ISS | GO:0042753 | positive regulation of circadian rhythm |
| BP | IEA | GO:0043122 | regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IDA | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| BP | TAS | GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| BP | TAS | GO:0043687 | post-translational protein modification |
| BP | IMP | GO:0045862 | positive regulation of proteolysis |
| BP | TAS | GO:0045879 | negative regulation of smoothened signaling pathway |
| BP | IMP | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | ISS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IEA | GO:0048511 | rhythmic process |
| BP | TAS | GO:0051403 | stress-activated MAPK cascade |
| BP | IEA | GO:0051726 | regulation of cell cycle |
| BP | IEA | GO:0060444 | branching involved in mammary gland duct morphogenesis |
| BP | IC | GO:0060828 | regulation of canonical Wnt signaling pathway |
| BP | IEA | GO:0061136 | regulation of proteasomal protein catabolic process |
| BP | TAS | GO:0070498 | interleukin-1-mediated signaling pathway |
| BP | IEA | GO:0071407 | cellular response to organic cyclic compound |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0019005 | SCF ubiquitin ligase complex |
| CC | IBA | GO:0032040 | small-subunit processome |
| CC | IBA | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome |
Gene expression in normal tissue: BTRC
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BTRC
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04340 | Hedgehog signaling pathway - Homo sapiens (human) |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa04710 | Circadian rhythm - Homo sapiens (human) |
| kegg | hsa05131 | Shigellosis - Homo sapiens (human) |
| pid | betacatenin_deg_pathway | Degradation of beta catenin |
| pid | betacatenin_nuc_pathway | Regulation of nuclear beta catenin signaling and target gene transcription |
| pid | hdac_classi_pathway | Signaling events mediated by HDAC Class I |
| pid | hedgehog_glipathway | Hedgehog signaling events mediated by Gli proteins |
| pid | nfkappabalternativepathway | Alternative NF-kappaB pathway |
| pid | nfkappabatypicalpathway | Atypical NF-kappaB pathway |
| pid | nfkappabcanonicalpathway | Canonical NF-kappaB pathway |
| pid | ps1pathway | Presenilin action in Notch and Wnt signaling |
| pid | tap63pathway | Validated transcriptional targets of TAp63 isoforms |
| netpath | Pathway_Prolactin | Prolactin |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| netpath | Pathway_TNFalpha | TNFalpha |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| reactome | R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) |
| reactome | R-HSA-1169091 | Activation of NF-kappaB in B cells |
| reactome | R-HSA-1170546 | Prolactin receptor signaling |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162909 | Host Interactions of HIV factors |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 |
| reactome | R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins |
| reactome | R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase |
| reactome | R-HSA-180534 | Vpu mediated degradation of CD4 |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-195253 | Degradation of beta-catenin by the destruction complex |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-202403 | TCR signaling |
| reactome | R-HSA-202424 | Downstream TCR signaling |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition |
| reactome | R-HSA-2871837 | FCERI mediated NF-kB activation |
| reactome | R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-400253 | Circadian Clock |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-448424 | Interleukin-17 signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-450294 | MAP kinase activation |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-453276 | Regulation of mitotic cell cycle |
| reactome | R-HSA-5358351 | Signaling by Hedgehog |
| reactome | R-HSA-5358351 | Signaling by Hedgehog |
| reactome | R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling |
| reactome | R-HSA-5607764 | CLEC7A (Dectin-1) signaling |
| reactome | R-HSA-5610780 | Degradation of GLI1 by the proteasome |
| reactome | R-HSA-5610783 | Degradation of GLI2 by the proteasome |
| reactome | R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome |
| reactome | R-HSA-5610787 | Hedgehog 'off' state |
| reactome | R-HSA-5610787 | Hedgehog 'off' state |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway |
| reactome | R-HSA-5676590 | NIK-->noncanonical NF-kB signaling |
| reactome | R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-8951664 | Neddylation |
| reactome | R-HSA-9020702 | Interleukin-1 signaling |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
| reactome | R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| biocarta | gsk3pathway | inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages |
| biocarta | wntpathway | wnt signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD100 | Zebularine | 3 |
| iGMDRD188 | Piperlongumine | 7 |
| iGMDRD888 | Compound 44 | 6 |
| iGMDRD60 | Quinoclamine | 8 |
| iGMDRD524 | ISX-9 | 1 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD255 | SB225002 | 5 |
| iGMDRD52 | Rotenone | 4 |
| iGMDRD187 | BRD9876 | 4 |
| iGMDRD318 | PAC-1 | 6 |
| iGMDRD446 | LY 2183240 | 6 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD494 | Neopeltolide | 4 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD263 | AACOCF3 | 2 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD505 | Pevonedistat | 6 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD330 | BRD4132 | 5 |
| iGMDRD248 | BRD4354 | 3 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD150 | RITA | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BTRC
CLASSFICATION
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