ERN2
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| endoplasmic reticulum to nucleus signaling 2 | MIM:604034 | Ensembl:ENSG00000134398 | HGNC:HGNC:16942 | PA134889542 | 16p12.2 |
GO terms in ERN2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000287 | magnesium ion binding |
| MF | IDA | GO:0004519 | endonuclease activity |
| MF | IEA | GO:0004540 | ribonuclease activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0005524 | ATP binding |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006397 | mRNA processing |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0007050 | cell cycle arrest |
| BP | IEA | GO:0007257 | activation of JUN kinase activity |
| BP | IDA | GO:0016075 | rRNA catabolic process |
| BP | IMP | GO:0030263 | apoptotic chromosome condensation |
| BP | TAS | GO:0034976 | response to endoplasmic reticulum stress |
| BP | IMP | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IEA | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| BP | IEA | GO:0090501 | RNA phosphodiester bond hydrolysis |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | ISS | GO:1990604 | IRE1-TRAF2-ASK1 complex |
Gene expression in normal tissue: ERN2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ERN2
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD427 | ABT737 | 6 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD126 | Tipifarnib | 5 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD444 | Tivantinib | 2 |
| iGMDRD23 | Gossypol | 4 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD398 | Sepantronium | 6 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD474 | Avrainvillamide | 4 |
| iGMDRD270 | Ciclosporin | 3 |
| iGMDRD945 | ML214 | 5 |
| iGMDRD341 | Triacsin c | 4 |
| iGMDRD698 | Neratinib | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD147 | Prima-1 | 2 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD192 | CIL56 | 1 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD220 | fumonisin B1 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ERN2
CLASSFICATION
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