PTPRD


Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
protein tyrosine phosphatase, receptor type DMIM:601598Ensembl:ENSG00000153707HGNC:HGNC:9668PA340139p24.1-p23

GO terms in PTPRD


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0005001transmembrane receptor protein tyrosine phosphatase activity
MFISSGO:0005102signaling receptor binding
MFIPIGO:0005515protein binding
MFISSGO:0050839cell adhesion molecule binding
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCHDAGO:0070062extracellular exosome
BPTASGO:0006470protein dephosphorylation
BPNASGO:0006796phosphate-containing compound metabolic process
BPISSGO:0007157heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
BPTASGO:0007185transmembrane receptor protein tyrosine phosphatase signaling pathway
BPISSGO:0030182neuron differentiation
BPIEAGO:0035335peptidyl-tyrosine dephosphorylation
BPISSGO:0050775positive regulation of dendrite morphogenesis
BPISSGO:0051965positive regulation of synapse assembly
BPISSGO:0097105presynaptic membrane assembly

Gene expression in normal tissue: PTPRD

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PTPRD


DatabasePathway IDPathway Des.
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-388844Receptor-type tyrosine-protein phosphatases
reactomeR-HSA-6794362Protein-protein interactions at synapses
reactomeR-HSA-8849932Synaptic adhesion-like molecules

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD679Bistramide A5
iGMDRD316N9-Isopropyl-olomoucine3
iGMDRD152179324-69-73
iGMDRD61Kinetin riboside5
iGMDRD427ABT7375
iGMDRD781Sirolimus4
iGMDRD151CHM-11
iGMDRD433Lexibulin6
iGMDRD889Compound 7d-cis4
iGMDRD420Leucascandrolide A12
iGMDRD64Parbendazole2
iGMDRD874BRD89583
iGMDRD23Gossypol1
iGMDRD188Piperlongumine3
iGMDRD780PP-304
iGMDRD207Capsaicin1
iGMDRD171Pemetrexed1
iGMDRD8012,4-dideoxy-DC-45-A24
iGMDRD52Rotenone2
iGMDRD187BRD98762
iGMDRD513BML-2593
iGMDRD474Avrainvillamide5
iGMDRD260FQI-21
iGMDRD123Isoevodiamine2
iGMDRD945ML2143
iGMDRD583LDN 1931892
iGMDRD248BRD43543
iGMDRD552AZD-17753
iGMDRD322FK 8661
iGMDRD67PENFLURIDOL1
iGMDRD286Nsc 6328395
iGMDRD871BRD63682
iGMDRD105Triptolide1
iGMDRD289Parthenolide3
iGMDRD121GMX17783
iGMDRD137Indisulam3
iGMDRD925IGF1R inhibitor1
iGMDRD297Austocystin D4
iGMDRD280CYTOCHALASIN B3
iGMDRD446LY 21832404
iGMDRD144NSC953971
iGMDRD494Neopeltolide4
iGMDRD266Cucurbitacin I1
iGMDRD995R15071
iGMDRD599Salermide1
iGMDRD451Serdemetan7
iGMDRD100Zebularine2
iGMDRD887Compound 23 citrate1
iGMDRD318PAC-12
iGMDRD870BRD636102
iGMDRD30917AAG1
iGMDRD138PX 122
iGMDRD255SB2250023
iGMDRD132(-)-gallocatechin-3-O-gallate2
iGMDRD57Chloropentafluorobenzene3
iGMDRD924IGF1R antibodies1
iGMDRD701NVP-AUY9221
iGMDRD307Manumycin A1
iGMDRD607Ubistatin B1
iGMDRD148Pifithrin-mu2
iGMDRD886Compound 1541A2
iGMDRD505Pevonedistat2
iGMDRD300Tozasertib3
iGMDRD246NPC262
iGMDRD42Vorinostat2
iGMDRD884Cixutumumab1
iGMDRD414MST-3121
iGMDRD882CIL411
iGMDRD872BRD71372
iGMDRD267Oligomycin A5

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PTPRD

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