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DDR1

Summary: Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
discoidin domain receptor tyrosine kinase 1	MIM:600408	Ensembl:ENSG00000204580	HGNC:HGNC:2730	PA24348	6p21.33

Gene Categories:

KINASE DRUGGABLE GENOME TYROSINE KINASE

GO terms in DDR1

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0004709	MAP kinase kinase kinase activity
MF	IBA	GO:0004713	protein tyrosine kinase activity
MF	IBA	GO:0004714	transmembrane receptor protein tyrosine kinase activity
MF	TAS	GO:0004714	transmembrane receptor protein tyrosine kinase activity
MF	IBA	GO:0004888	transmembrane signaling receptor activity
MF	IPI	GO:0005515	protein binding
MF	IBA	GO:0005518	collagen binding
MF	IDA	GO:0005518	collagen binding
MF	IMP	GO:0005518	collagen binding
MF	IEA	GO:0005524	ATP binding
MF	IBA	GO:0031434	mitogen-activated protein kinase kinase binding
MF	IBA	GO:0038062	protein tyrosine kinase collagen receptor activity
MF	IDA	GO:0038062	protein tyrosine kinase collagen receptor activity
MF	IEA	GO:0046872	metal ion binding
BP	IEA	GO:0001558	regulation of cell growth
BP	IEA	GO:0001952	regulation of cell-matrix adhesion
BP	TAS	GO:0007155	cell adhesion
BP	IBA	GO:0007275	multicellular organism development
BP	IEA	GO:0007566	embryo implantation
BP	IEA	GO:0007595	lactation
BP	IEA	GO:0008285	negative regulation of cell proliferation
BP	IBA	GO:0009968	negative regulation of signal transduction
BP	IMP	GO:0010715	regulation of extracellular matrix disassembly
BP	IMP	GO:0014909	smooth muscle cell migration
BP	IBA	GO:0030154	cell differentiation
BP	TAS	GO:0030198	extracellular matrix organization
BP	IBA	GO:0033674	positive regulation of kinase activity
BP	IDA	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway
BP	IMP	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway
BP	IDA	GO:0038083	peptidyl-tyrosine autophosphorylation
BP	IBA	GO:0043066	negative regulation of apoptotic process
BP	IEA	GO:0043583	ear development
BP	IBA	GO:0044319	wound healing, spreading of cells
BP	IMP	GO:0044319	wound healing, spreading of cells
BP	IDA	GO:0046777	protein autophosphorylation
BP	IEA	GO:0060444	branching involved in mammary gland duct morphogenesis
BP	IEA	GO:0060749	mammary gland alveolus development
BP	IMP	GO:0061302	smooth muscle cell-matrix adhesion
BP	IEA	GO:0061564	axon development
BP	IBA	GO:0070374	positive regulation of ERK1 and ERK2 cascade
BP	IEA	GO:1990138	neuron projection extension
CC	HDA	GO:0005615	extracellular space
CC	IBA	GO:0005737	cytoplasm
CC	TAS	GO:0005886	plasma membrane
CC	IBA	GO:0005887	integral component of plasma membrane
CC	IEA	GO:0005887	integral component of plasma membrane
CC	IBA	GO:0043235	receptor complex
CC	IDA	GO:0043235	receptor complex
CC	HDA	GO:0070062	extracellular exosome

Gene expression in normal tissue: DDR1

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DDR1

Database	Pathway ID	Pathway Des.
wikipathways	WP3670	Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway
reactome	R-HSA-1474244	Extracellular matrix organization
reactome	R-HSA-3000171	Non-integrin membrane-ECM interactions

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD85	Ursolic acid	3
iGMDRD132	(-)-gallocatechin-3-O-gallate	1
iGMDRD123	Isoevodiamine	2
iGMDRD148	Pifithrin-mu	3
iGMDRD307	Manumycin A	2
iGMDRD84	Lovastatin acid	2
iGMDRD79	Gemcitabine	2
iGMDRD345	Compound 10b [PMID: 11504634]	1
iGMDRD116	CD437	3
iGMDRD329	Merck60	3
iGMDRD882	CIL41	2
iGMDRD286	Nsc 632839	2
iGMDRD82	Quiflapon	1
iGMDRD246	NPC26	2
iGMDRD147	Prima-1	2
iGMDRD300	Tozasertib	3
iGMDRD505	Pevonedistat	6
iGMDRD121	GMX1778	2
iGMDRD202	Curcumin	4
iGMDRD137	Indisulam	2
iGMDRD103	SN-38	3
iGMDRD434	BMS-536924	3
iGMDRD705	Nakiterpiosin	3
iGMDRD193	Fqi1	1
iGMDRD61	Kinetin riboside	5
iGMDRD639	YK 4-279	3
iGMDRD446	LY 2183240	2
iGMDRD280	CYTOCHALASIN B	3
iGMDRD772	BRD4770	5
iGMDRD425	ERASTIN	2
iGMDRD387	CHIR-99021	2
iGMDRD151	CHM-1	3
iGMDRD433	Lexibulin	3
iGMDRD126	Tipifarnib	3
iGMDRD781	Sirolimus	7
iGMDRD562	Navitoclax	1
iGMDRD398	Sepantronium	3
iGMDRD780	PP-30	2
iGMDRD506	Fedratinib	3
iGMDRD888	Compound 44	4
iGMDRD577	BIX01294	3
iGMDRD399	Selumetinib	3
iGMDRD887	Compound 23 citrate	3
iGMDRD690	PRIMA-1MET	2
iGMDRD255	SB225002	2
iGMDRD260	FQI-2	3
iGMDRD138	PX 12	2
iGMDRD474	Avrainvillamide	3
iGMDRD187	BRD9876	2
iGMDRD870	BRD63610	3
iGMDRD318	PAC-1	3
iGMDRD885	Compound 110	1
iGMDRD782	DC-45-A2	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DDR1

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.