ADAMTS18


Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may regulate hemostatic balance and function as a tumor suppressor. Mutations in this gene may be associated with microcornea, myopic chorioretinal atrophy, and telecanthus (MMCAT) and cone-rod dystrophy in human patients. [provided by RefSeq, May 2016].

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GO terms in ADAMTS18


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0004222 metalloendopeptidase activity
MF IEA GO:0046872 metal ion binding
CC IEA GO:0005576 extracellular region
BP IMP GO:0001654 eye development
BP IEA GO:0006508 proteolysis
BP IDA GO:0090331 negative regulation of platelet aggregation
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Gene expression in normal tissue: ADAMTS18

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined24PI3K/MTOR signaling2Mitosis1Metabolism1Other, kinases1Chromatin other1Chromatin histone acetylation1Protein stability and degradation1Cell cycle1DNA replication1

Pathways in ADAMTS18


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1474228 Degradation of the extracellular matrix
reactome R-HSA-1474244 Extracellular matrix organization
reactome R-HSA-1643685 Disease
reactome R-HSA-3781865 Diseases of glycosylation
reactome R-HSA-3906995 Diseases associated with O-glycosylation of proteins
reactome R-HSA-392499 Metabolism of proteins
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD307 Manumycin A 2
iGMDRD84 Lovastatin acid 2
iGMDRD701 NVP-AUY922 2
iGMDRD85 Ursolic acid 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ADAMTS18

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