SRPK3
Summary: This gene encodes a protein kinase similar to a protein kinase which is specific for the SR (serine/arginine-rich domain) family of splicing factors. A highly similar protein has been shown to play a role in muscle development in mice. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SRSF protein kinase 3 | MIM:301002 | Ensembl:ENSG00000184343 | HGNC:HGNC:11402 | PA162404805 | Xq28 |
GO terms in SRPK3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| CC | ND | GO:0005575 | cellular_component |
| CC | IBA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| BP | IBA | GO:0000245 | spliceosomal complex assembly |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0007519 | skeletal muscle tissue development |
| BP | IBA | GO:0010468 | regulation of gene expression |
| BP | IEA | GO:0030154 | cell differentiation |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IBA | GO:0050684 | regulation of mRNA processing |
| BP | ISS | GO:0060537 | muscle tissue development |
Gene expression in normal tissue: SRPK3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SRPK3
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD148 | Pifithrin-mu | 1 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD48 | Dexamethasone | 3 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD227 | Fatostatin A | 3 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD300 | Tozasertib | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SRPK3
CLASSFICATION
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