GRB2

Summary: The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namegrowth factor receptor bound protein 2
OMIM IDMIM:108355
Ensembl IDEnsembl:ENSG00000177885
HGNC IDHGNC:HGNC:4566
PHARMGKB IDPA28962
Map Location17q25.1

Gene Categories:

TYROSINE KINASEKINASE

GO terms in GRB2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0001784 phosphotyrosine residue binding
MF HDA GO:0003723 RNA binding
MF TAS GO:0005070 SH3/SH2 adaptor activity
MF TAS GO:0005088 Ras guanyl-nucleotide exchange factor activity
MF IPI GO:0005154 epidermal growth factor receptor binding
MF IPI GO:0005168 neurotrophin TRKA receptor binding
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Gene expression in normal tissue: GRB2

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 18LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 18

Gene-drug pathway distribution

undefined8Apoptosis regulation1

Pathways in GRB2


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Database
Pathway ID
Pathway Des.
kegg hsa04010 MAPK signaling pathway - Homo sapiens (human)
kegg hsa04012 ErbB signaling pathway - Homo sapiens (human)
kegg hsa04014 Ras signaling pathway - Homo sapiens (human)
kegg hsa04062 Chemokine signaling pathway - Homo sapiens (human)
kegg hsa04068 FoxO signaling pathway - Homo sapiens (human)
kegg hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD137 Indisulam 5
iGMDRD474 Avrainvillamide 6
iGMDRD144 NSC95397 3
iGMDRD318 PAC-1 6
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GRB2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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