GRB2


Summary: The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
growth factor receptor bound protein 2MIM:108355Ensembl:ENSG00000177885HGNC:HGNC:4566PA2896217q25.1

Gene Categories:

TYROSINE KINASEKINASE

GO terms in GRB2


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0001784phosphotyrosine residue binding
MFHDAGO:0003723RNA binding
MFTASGO:0005070SH3/SH2 adaptor activity
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFIPIGO:0005154epidermal growth factor receptor binding
MFIPIGO:0005168neurotrophin TRKA receptor binding
MFIPIGO:0005515protein binding
MFTASGO:00163031-phosphatidylinositol-3-kinase activity
MFIDAGO:0017124SH3 domain binding
MFIPIGO:0019901protein kinase binding
MFIEAGO:0019903protein phosphatase binding
MFIPIGO:0042802identical protein binding
MFIPIGO:0043560insulin receptor substrate binding
MFIPIGO:0046875ephrin receptor binding
MFTASGO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity
BPTASGO:0000165MAPK cascade
BPTASGO:0007173epidermal growth factor receptor signaling pathway
BPTASGO:0007265Ras protein signal transduction
BPTASGO:0007267cell-cell signaling
BPTASGO:0007411axon guidance
BPIEAGO:0007568aging
BPIPIGO:0008286insulin receptor signaling pathway
BPTASGO:0008286insulin receptor signaling pathway
BPTASGO:0008543fibroblast growth factor receptor signaling pathway
BPIEAGO:0016032viral process
BPTASGO:0019221cytokine-mediated signaling pathway
BPIEAGO:0030838positive regulation of actin filament polymerization
BPTASGO:0031295T cell costimulation
BPIMPGO:0031623receptor internalization
BPTASGO:0035635entry of bacterium into host cell
BPTASGO:0035723interleukin-15-mediated signaling pathway
BPIEAGO:0036092phosphatidylinositol-3-phosphate biosynthetic process
BPTASGO:0038095Fc-epsilon receptor signaling pathway
BPTASGO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis
BPTASGO:0038128ERBB2 signaling pathway
BPTASGO:0042059negative regulation of epidermal growth factor receptor signaling pathway
BPIMPGO:0042770signal transduction in response to DNA damage
BPIEAGO:0043408regulation of MAPK cascade
BPIEAGO:0046854phosphatidylinositol phosphorylation
BPTASGO:0048011neurotrophin TRK receptor signaling pathway
BPIEAGO:0048646anatomical structure formation involved in morphogenesis
BPTASGO:0050900leukocyte migration
BPIEAGO:0051291protein heterooligomerization
BPTASGO:0051897positive regulation of protein kinase B signaling
BPIEAGO:0060670branching involved in labyrinthine layer morphogenesis
BPTASGO:0061024membrane organization
BPIMPGO:0071479cellular response to ionizing radiation
BPIMPGO:2000379positive regulation of reactive oxygen species metabolic process
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005730nucleolus
CCIDAGO:0005737cytoplasm
CCIDAGO:0005768endosome
CCIEAGO:0005794Golgi apparatus
CCTASGO:0005829cytosol
CCTASGO:0005886plasma membrane
CCIEAGO:0005911cell-cell junction
CCIDAGO:0008180COP9 signalosome
CCIEAGO:0012506vesicle membrane
CCHDAGO:0070062extracellular exosome
CCIDAGO:0070436Grb2-EGFR complex

Gene expression in normal tissue: GRB2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GRB2


DatabasePathway IDPathway Des.
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04540Gap junction - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04662B cell receptor signaling pathway - Homo sapiens (human)
kegghsa04664Fc epsilon RI signaling pathway - Homo sapiens (human)
kegghsa04714Thermogenesis - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa04912GnRH signaling pathway - Homo sapiens (human)
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
kegghsa04917Prolactin signaling pathway - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa05034Alcoholism - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05211Renal cell carcinoma - Homo sapiens (human)
kegghsa05213Endometrial cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05221Acute myeloid leukemia - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
kegghsa05231Choline metabolism in cancer - Homo sapiens (human)
netpathPathway_Alpha6Beta4IntegrinAlpha6Beta4Integrin
netpathPathway_BCRBCR
netpathPathway_BDNFBDNF
netpathPathway_EGFR1EGFR1
netpathPathway_Fibroblast__growth__factor-1Fibroblast growth factor-1
netpathPathway_GastrinGastrin
netpathPathway_GhrelinGhrelin
netpathPathway_IL2IL2
netpathPathway_IL3IL3
netpathPathway_IL4IL4
netpathPathway_IL5IL5
netpathPathway_IL6IL6
netpathPathway_KitReceptorKitReceptor
netpathPathway_LeptinLeptin
netpathPathway_Oncostatin_MOncostatin_M
netpathPathway_ProlactinProlactin
netpathPathway_TCRTCR
netpathPathway_TNFalphaTNFalpha
biocartaat1rpathwayangiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling
biocartabcrpathwaybcr signaling pathway
biocartabiopeptidespathwaybioactive peptide induced signaling pathway
biocartacardiacegfpathwayrole of egf receptor transactivation by gpcrs in cardiac hypertrophy
biocartacblpathwaycbl mediated ligand-induced downregulation of egf receptors pathway
biocartacdk5pathwayphosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway
biocartacrebpathwaytranscription factor creb and its extracellular signals
biocartactla4pathwaythe co-stimulatory signal during t-cell activation
biocartaedg1pathwayphospholipids as signalling intermediaries
biocartaegfpathwayegf signaling pathway
biocartaepopathwayepo signaling pathway
biocartaerk5pathwayrole of erk5 in neuronal survival pathway
biocartaerkpathwayerk1/erk2 mapk signaling pathway
biocartafcer1pathwayfc epsilon receptor i signaling in mast cells
biocartaghpathwaygrowth hormone signaling pathway
biocartagleevecpathwayinhibition of cellular proliferation by gleevec
biocartahbxpathwaycalcium signaling by hbx of hepatitis b virus
biocartaher2pathwayrole of erbb2 in signal transduction and oncology
biocartaigf1pathwayigf-1 signaling pathway
biocartaigf1rpathwaymultiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation
biocartail2pathwayil 2 signaling pathway
biocartail2rbpathwayil-2 receptor beta chain in t cell activation
biocartail3pathwayil 3 signaling pathway
biocartail4pathwayil 4 signaling pathway
biocartail6pathwayil 6 signaling pathway
biocartainsulinpathwayinsulin signaling pathway
biocartaintegrinpathwayintegrin signaling pathway
biocartakeratinocytepathwaykeratinocyte differentiation
biocartalongevitypathwaythe igf-1 receptor and longevity
biocartamcalpainpathwaymcalpain and friends in cell motility
biocartanfatpathwaynfat and hypertrophy of the heart
biocartangfpathwaynerve growth factor pathway (ngf)
biocartapdgfpathwaypdgf signaling pathway
biocartaptenpathwaypten dependent cell cycle arrest and apoptosis
biocartapyk2pathwaylinks between pyk2 and map kinases
biocartasmrtepathwaymap kinase inactivation of smrt corepressor
biocartasprypathwaysprouty regulation of tyrosine kinase signals
biocartatcrpathwayt cell receptor signaling pathway
biocartatffpathwaytrefoil factors initiate mucosal healing
biocartatpopathwaytpo signaling pathway
biocartatrkapathwaytrka receptor signaling pathway
biocartavegfpathwayvegf hypoxia and angiogenesis
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-109704PI3K Cascade
reactomeR-HSA-112399IRS-mediated signalling
reactomeR-HSA-112399IRS-mediated signalling
reactomeR-HSA-112412SOS-mediated signalling
reactomeR-HSA-112412SOS-mediated signalling
reactomeR-HSA-1226099Signaling by FGFR in disease
reactomeR-HSA-1227986Signaling by ERBB2
reactomeR-HSA-1227986Signaling by ERBB2
reactomeR-HSA-1236382Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
reactomeR-HSA-1236394Signaling by ERBB4
reactomeR-HSA-1250196SHC1 events in ERBB2 signaling
reactomeR-HSA-1250347SHC1 events in ERBB4 signaling
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1295596Spry regulation of FGF signaling
reactomeR-HSA-1433557Signaling by SCF-KIT
reactomeR-HSA-1433559Regulation of KIT signaling
reactomeR-HSA-1500931Cell-Cell communication
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-1643685Disease
reactomeR-HSA-1643713Signaling by EGFR in Cancer
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-167044Signalling to RAS
reactomeR-HSA-167044Signalling to RAS
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-177929Signaling by EGFR
reactomeR-HSA-179812GRB2 events in EGFR signaling
reactomeR-HSA-180292GAB1 signalosome
reactomeR-HSA-180336SHC1 events in EGFR signaling
reactomeR-HSA-182971EGFR downregulation
reactomeR-HSA-1839117Signaling by cytosolic FGFR1 fusion mutants
reactomeR-HSA-1839124FGFR1 mutant receptor activation
reactomeR-HSA-186763Downstream signal transduction
reactomeR-HSA-186797Signaling by PDGF
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-187687Signalling to ERKs
reactomeR-HSA-187687Signalling to ERKs
reactomeR-HSA-190236Signaling by FGFR
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-1963640GRB2 events in ERBB2 signaling
reactomeR-HSA-1963640GRB2 events in ERBB2 signaling
reactomeR-HSA-1963642PI3K events in ERBB2 signaling
reactomeR-HSA-199418Negative regulation of the PI3K/AKT network
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-202733Cell surface interactions at the vascular wall
reactomeR-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosis
reactomeR-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosis
reactomeR-HSA-2029482Regulation of actin dynamics for phagocytic cup formation
reactomeR-HSA-2029482Regulation of actin dynamics for phagocytic cup formation
reactomeR-HSA-210993Tie2 Signaling
reactomeR-HSA-2172127DAP12 interactions
reactomeR-HSA-2179392EGFR Transactivation by Gastrin
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-2219530Constitutive Signaling by Aberrant PI3K in Cancer
reactomeR-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactomeR-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactomeR-HSA-2424491DAP12 signaling
reactomeR-HSA-2428924IGF1R signaling cascade
reactomeR-HSA-2428924IGF1R signaling cascade
reactomeR-HSA-2428928IRS-related events triggered by IGF1R
reactomeR-HSA-2428928IRS-related events triggered by IGF1R
reactomeR-HSA-2428933SHC-related events triggered by IGF1R
reactomeR-HSA-2428933SHC-related events triggered by IGF1R
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2730905Role of LAT2/NTAL/LAB on calcium mobilization
reactomeR-HSA-2730905Role of LAT2/NTAL/LAB on calcium mobilization
reactomeR-HSA-2871796FCERI mediated MAPK activation
reactomeR-HSA-2871809FCERI mediated Ca+2 mobilization
reactomeR-HSA-2871809FCERI mediated Ca+2 mobilization
reactomeR-HSA-354192Integrin alphaIIb beta3 signaling
reactomeR-HSA-354194GRB2:SOS provides linkage to MAPK signaling for Integrins
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-375165NCAM signaling for neurite out-growth
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-388841Costimulation by the CD28 family
reactomeR-HSA-389356CD28 co-stimulation
reactomeR-HSA-389359CD28 dependent Vav1 pathway
reactomeR-HSA-391160Signal regulatory protein family interactions
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-451927Interleukin-2 family signaling
reactomeR-HSA-451927Interleukin-2 family signaling
reactomeR-HSA-512988Interleukin-3, Interleukin-5 and GM-CSF signaling
reactomeR-HSA-512988Interleukin-3, Interleukin-5 and GM-CSF signaling
reactomeR-HSA-5637810Constitutive Signaling by EGFRvIII
reactomeR-HSA-5637812Signaling by EGFRvIII in Cancer
reactomeR-HSA-5637815Signaling by Ligand-Responsive EGFR Variants in Cancer
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-5654687Downstream signaling of activated FGFR1
reactomeR-HSA-5654688SHC-mediated cascade:FGFR1
reactomeR-HSA-5654689PI-3K cascade:FGFR1
reactomeR-HSA-5654693FRS-mediated FGFR1 signaling
reactomeR-HSA-5654695PI-3K cascade:FGFR2
reactomeR-HSA-5654696Downstream signaling of activated FGFR2
reactomeR-HSA-5654699SHC-mediated cascade:FGFR2
reactomeR-HSA-5654700FRS-mediated FGFR2 signaling
reactomeR-HSA-5654704SHC-mediated cascade:FGFR3
reactomeR-HSA-5654706FRS-mediated FGFR3 signaling
reactomeR-HSA-5654708Downstream signaling of activated FGFR3
reactomeR-HSA-5654710PI-3K cascade:FGFR3
reactomeR-HSA-5654712FRS-mediated FGFR4 signaling
reactomeR-HSA-5654716Downstream signaling of activated FGFR4
reactomeR-HSA-5654719SHC-mediated cascade:FGFR4
reactomeR-HSA-5654720PI-3K cascade:FGFR4
reactomeR-HSA-5654726Negative regulation of FGFR1 signaling
reactomeR-HSA-5654727Negative regulation of FGFR2 signaling
reactomeR-HSA-5654732Negative regulation of FGFR3 signaling
reactomeR-HSA-5654733Negative regulation of FGFR4 signaling
reactomeR-HSA-5654736Signaling by FGFR1
reactomeR-HSA-5654738Signaling by FGFR2
reactomeR-HSA-5654741Signaling by FGFR3
reactomeR-HSA-5654743Signaling by FGFR4
reactomeR-HSA-5655253Signaling by FGFR2 in disease
reactomeR-HSA-5655291Signaling by FGFR4 in disease
reactomeR-HSA-5655302Signaling by FGFR1 in disease
reactomeR-HSA-5655332Signaling by FGFR3 in disease
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-5663213RHO GTPases Activate WASPs and WAVEs
reactomeR-HSA-5663213RHO GTPases Activate WASPs and WAVEs
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6806834Signaling by MET
reactomeR-HSA-6807004Negative regulation of MET activity
reactomeR-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
reactomeR-HSA-74749Signal attenuation
reactomeR-HSA-74751Insulin receptor signalling cascade
reactomeR-HSA-74751Insulin receptor signalling cascade
reactomeR-HSA-74752Signaling by Insulin receptor
reactomeR-HSA-74752Signaling by Insulin receptor
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76009Platelet Aggregation (Plug Formation)
reactomeR-HSA-881907Gastrin-CREB signalling pathway via PKC and MAPK
reactomeR-HSA-8851805MET activates RAS signaling
reactomeR-HSA-8851907MET activates PI3K/AKT signaling
reactomeR-HSA-8853334Signaling by FGFR3 fusions in cancer
reactomeR-HSA-8853338Signaling by FGFR3 point mutants in cancer
reactomeR-HSA-8853659RET signaling
reactomeR-HSA-8856825Cargo recognition for clathrin-mediated endocytosis
reactomeR-HSA-8856828Clathrin-mediated endocytosis
reactomeR-HSA-8865999MET activates PTPN11
reactomeR-HSA-8875360InlB-mediated entry of Listeria monocytogenes into host cell
reactomeR-HSA-8875360InlB-mediated entry of Listeria monocytogenes into host cell
reactomeR-HSA-8875555MET activates RAP1 and RAC1
reactomeR-HSA-8875656MET receptor recycling
reactomeR-HSA-8875878MET promotes cell motility
reactomeR-HSA-8876384Listeria monocytogenes entry into host cells
reactomeR-HSA-8876384Listeria monocytogenes entry into host cells
reactomeR-HSA-8983432Interleukin-15 signaling
reactomeR-HSA-8983432Interleukin-15 signaling
reactomeR-HSA-9006115Signaling by NTRK2 (TRKB)
reactomeR-HSA-9006115Signaling by NTRK2 (TRKB)
reactomeR-HSA-9006921Integrin signaling
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9026519Activated NTRK2 signals through RAS
reactomeR-HSA-9028335Activated NTRK2 signals through PI3K
reactomeR-HSA-9028731Activated NTRK2 signals through FRS2 and FRS3
reactomeR-HSA-9028731Activated NTRK2 signals through FRS2 and FRS3
reactomeR-HSA-9034015Signaling by NTRK3 (TRKC)
reactomeR-HSA-9034864Activated NTRK3 signals through RAS
reactomeR-HSA-912526Interleukin receptor SHC signaling
reactomeR-HSA-912631Regulation of signaling by CBL
reactomeR-HSA-912631Regulation of signaling by CBL
reactomeR-HSA-983695Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
reactomeR-HSA-983705Signaling by the B Cell Receptor (BCR)
smpdbSMP00358Fc Epsilon Receptor I Signaling in Mast Cells
smpdbSMP00391Insulin Signalling
wikipathwaysWP127IL-5 Signaling Pathway
wikipathwaysWP185Integrin-mediated Cell Adhesion
wikipathwaysWP1993Angiogenesis overview
wikipathwaysWP2034Leptin signaling pathway
wikipathwaysWP2037Prolactin Signaling Pathway
wikipathwaysWP22IL-9 Signaling Pathway
wikipathwaysWP2253Pilocytic astrocytoma
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP2263Androgen Receptor Network in Prostate Cancer
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP2332Interleukin-11 Signaling Pathway
wikipathwaysWP2374Oncostatin M Signaling Pathway
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP244Alpha 6 Beta 4 signaling pathway
wikipathwaysWP2593JAK-STAT
wikipathwaysWP286IL-3 Signaling Pathway
wikipathwaysWP304Kit receptor signaling pathway
wikipathwaysWP306Focal Adhesion
wikipathwaysWP313Signaling of Hepatocyte Growth Factor Receptor
wikipathwaysWP3303Rac1-Pak1-p38-MMP-2 pathway
wikipathwaysWP364IL-6 signaling pathway
wikipathwaysWP3646Hepatitis C and Hepatocellular Carcinoma
wikipathwaysWP366TGF-beta Signaling Pathway
wikipathwaysWP3676BDNF-TrkB Signaling
wikipathwaysWP3680Association Between Physico-Chemical Features and Toxicity Associated Pathways
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3863T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP395IL-4 Signaling Pathway
wikipathwaysWP3972PDGFR-beta pathway
wikipathwaysWP3981miRNA regulation of prostate cancer signaling pathways
wikipathwaysWP400p38 MAPK Signaling Pathway
wikipathwaysWP4155Endometrial cancer
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4205MET in type 1 papillary renal cell carcinoma
wikipathwaysWP4223Ras Signaling
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP481Insulin Signaling
wikipathwaysWP49IL-2 Signaling Pathway
wikipathwaysWP581EPO Receptor Signaling
wikipathwaysWP673ErbB Signaling Pathway
wikipathwaysWP69T-Cell antigen Receptor (TCR) Signaling Pathway
wikipathwaysWP710DNA Damage Response (only ATM dependent)
pida6b1_a6b4_integrin_pathwaya6b1 and a6b4 Integrin signaling
pidangiopoietinreceptor_pathwayAngiopoietin receptor Tie2-mediated signaling
pidbcr_5pathwayBCR signaling pathway
pidcd8tcrpathwayTCR signaling in naïve CD8+ T cells
pidepha2_fwdpathwayEPHA2 forward signaling
pidephbfwdpathwayEPHB forward signaling
pidepopathwayEPO signaling pathway
pider_nongenomic_pathwayPlasma membrane estrogen receptor signaling
piderbb1_downstream_pathwayErbB1 downstream signaling
piderbb1_internalization_pathwayInternalization of ErbB1
piderbb2erbb3pathwayErbB2/ErbB3 signaling events
piderbb4_pathwayErbB4 signaling events
pidet_egfrpathwayEGFR-dependent Endothelin signaling events
pidfak_pathwaySignaling events mediated by focal adhesion kinase
pidfcer1pathwayFc-epsilon receptor I signaling in mast cells
pidfgf_pathwayFGF signaling pathway
pidgmcsf_pathwayGMCSF-mediated signaling events
pidigf1_pathwayIGF1 pathway
pidil2_1pathwayIL2-mediated signaling events
pidil2_pi3kpathwayIL2 signaling events mediated by PI3K
pidil2_stat5pathwayIL2 signaling events mediated by STAT5
pidil3_pathwayIL3-mediated signaling events
pidil4_2pathwayIL4-mediated signaling events
pidil5_pathwayIL5-mediated signaling events
pidil6_7pathwayIL6-mediated signaling events
pidinsulin_pathwayInsulin Pathway
pidkitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
pidlymphangiogenesis_pathwayVEGFR3 signaling in lymphatic endothelium
pidmet_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pidnephrin_neph1_pathwayNephrin/Neph1 signaling in the kidney podocyte
pidpdgfrapathwayPDGFR-alpha signaling pathway
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidpi3kplctrkpathwayTrk receptor signaling mediated by PI3K and PLC-gamma
pidptp1bpathwaySignaling events mediated by PTP1B
pidras_pathwayRegulation of Ras family activation
pidret_pathwaySignaling events regulated by Ret tyrosine kinase
pidshp2_pathwaySHP2 signaling
pidtcptp_pathwaySignaling events mediated by TCPTP
pidtcr_pathwayTCR signaling in naïve CD4+ T cells
pidtgfbrpathwayTGF-beta receptor signaling
pidtrkrpathwayNeurotrophic factor-mediated Trk receptor signaling
pidvegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
pharmgkbPA162356267EGFR Inhibitor Pathway, Pharmacodynamics

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD137Indisulam5
iGMDRD474Avrainvillamide6
iGMDRD144NSC953973
iGMDRD318PAC-16
iGMDRD871BRD63682
iGMDRD341Triacsin c6
iGMDRD286Nsc 6328393
iGMDRD188Piperlongumine3
iGMDRD886Compound 1541A2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GRB2

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