GRB2
Summary: The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| growth factor receptor bound protein 2 | MIM:108355 | Ensembl:ENSG00000177885 | HGNC:HGNC:4566 | PA28962 | 17q25.1 |
GO terms in GRB2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0001784 | phosphotyrosine residue binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | TAS | GO:0005070 | SH3/SH2 adaptor activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IPI | GO:0005154 | epidermal growth factor receptor binding |
| MF | IPI | GO:0005168 | neurotrophin TRKA receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0016303 | 1-phosphatidylinositol-3-kinase activity |
| MF | IDA | GO:0017124 | SH3 domain binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0019903 | protein phosphatase binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0043560 | insulin receptor substrate binding |
| MF | IPI | GO:0046875 | ephrin receptor binding |
| MF | TAS | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | TAS | GO:0007173 | epidermal growth factor receptor signaling pathway |
| BP | TAS | GO:0007265 | Ras protein signal transduction |
| BP | TAS | GO:0007267 | cell-cell signaling |
| BP | TAS | GO:0007411 | axon guidance |
| BP | IEA | GO:0007568 | aging |
| BP | IPI | GO:0008286 | insulin receptor signaling pathway |
| BP | TAS | GO:0008286 | insulin receptor signaling pathway |
| BP | TAS | GO:0008543 | fibroblast growth factor receptor signaling pathway |
| BP | IEA | GO:0016032 | viral process |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0030838 | positive regulation of actin filament polymerization |
| BP | TAS | GO:0031295 | T cell costimulation |
| BP | IMP | GO:0031623 | receptor internalization |
| BP | TAS | GO:0035635 | entry of bacterium into host cell |
| BP | TAS | GO:0035723 | interleukin-15-mediated signaling pathway |
| BP | IEA | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process |
| BP | TAS | GO:0038095 | Fc-epsilon receptor signaling pathway |
| BP | TAS | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| BP | TAS | GO:0038128 | ERBB2 signaling pathway |
| BP | TAS | GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway |
| BP | IMP | GO:0042770 | signal transduction in response to DNA damage |
| BP | IEA | GO:0043408 | regulation of MAPK cascade |
| BP | IEA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | TAS | GO:0048011 | neurotrophin TRK receptor signaling pathway |
| BP | IEA | GO:0048646 | anatomical structure formation involved in morphogenesis |
| BP | TAS | GO:0050900 | leukocyte migration |
| BP | IEA | GO:0051291 | protein heterooligomerization |
| BP | TAS | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IEA | GO:0060670 | branching involved in labyrinthine layer morphogenesis |
| BP | TAS | GO:0061024 | membrane organization |
| BP | IMP | GO:0071479 | cellular response to ionizing radiation |
| BP | IMP | GO:2000379 | positive regulation of reactive oxygen species metabolic process |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005768 | endosome |
| CC | IEA | GO:0005794 | Golgi apparatus |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005911 | cell-cell junction |
| CC | IDA | GO:0008180 | COP9 signalosome |
| CC | IEA | GO:0012506 | vesicle membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0070436 | Grb2-EGFR complex |
Gene expression in normal tissue: GRB2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GRB2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04540 | Gap junction - Homo sapiens (human) |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa05034 | Alcoholism - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| kegg | hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
| kegg | hsa05213 | Endometrial cancer - Homo sapiens (human) |
| kegg | hsa05214 | Glioma - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_BDNF | BDNF |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
| netpath | Pathway_Gastrin | Gastrin |
| netpath | Pathway_Ghrelin | Ghrelin |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_IL3 | IL3 |
| netpath | Pathway_IL4 | IL4 |
| netpath | Pathway_IL5 | IL5 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_KitReceptor | KitReceptor |
| netpath | Pathway_Leptin | Leptin |
| netpath | Pathway_Oncostatin_M | Oncostatin_M |
| netpath | Pathway_Prolactin | Prolactin |
| netpath | Pathway_TCR | TCR |
| netpath | Pathway_TNFalpha | TNFalpha |
| biocarta | at1rpathway | angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling |
| biocarta | bcrpathway | bcr signaling pathway |
| biocarta | biopeptidespathway | bioactive peptide induced signaling pathway |
| biocarta | cardiacegfpathway | role of egf receptor transactivation by gpcrs in cardiac hypertrophy |
| biocarta | cblpathway | cbl mediated ligand-induced downregulation of egf receptors pathway |
| biocarta | cdk5pathway | phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway |
| biocarta | crebpathway | transcription factor creb and its extracellular signals |
| biocarta | ctla4pathway | the co-stimulatory signal during t-cell activation |
| biocarta | edg1pathway | phospholipids as signalling intermediaries |
| biocarta | egfpathway | egf signaling pathway |
| biocarta | epopathway | epo signaling pathway |
| biocarta | erk5pathway | role of erk5 in neuronal survival pathway |
| biocarta | erkpathway | erk1/erk2 mapk signaling pathway |
| biocarta | fcer1pathway | fc epsilon receptor i signaling in mast cells |
| biocarta | ghpathway | growth hormone signaling pathway |
| biocarta | gleevecpathway | inhibition of cellular proliferation by gleevec |
| biocarta | hbxpathway | calcium signaling by hbx of hepatitis b virus |
| biocarta | her2pathway | role of erbb2 in signal transduction and oncology |
| biocarta | igf1pathway | igf-1 signaling pathway |
| biocarta | igf1rpathway | multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation |
| biocarta | il2pathway | il 2 signaling pathway |
| biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
| biocarta | il3pathway | il 3 signaling pathway |
| biocarta | il4pathway | il 4 signaling pathway |
| biocarta | il6pathway | il 6 signaling pathway |
| biocarta | insulinpathway | insulin signaling pathway |
| biocarta | integrinpathway | integrin signaling pathway |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| biocarta | longevitypathway | the igf-1 receptor and longevity |
| biocarta | mcalpainpathway | mcalpain and friends in cell motility |
| biocarta | nfatpathway | nfat and hypertrophy of the heart |
| biocarta | ngfpathway | nerve growth factor pathway (ngf) |
| biocarta | pdgfpathway | pdgf signaling pathway |
| biocarta | ptenpathway | pten dependent cell cycle arrest and apoptosis |
| biocarta | pyk2pathway | links between pyk2 and map kinases |
| biocarta | smrtepathway | map kinase inactivation of smrt corepressor |
| biocarta | sprypathway | sprouty regulation of tyrosine kinase signals |
| biocarta | tcrpathway | t cell receptor signaling pathway |
| biocarta | tffpathway | trefoil factors initiate mucosal healing |
| biocarta | tpopathway | tpo signaling pathway |
| biocarta | trkapathway | trka receptor signaling pathway |
| biocarta | vegfpathway | vegf hypoxia and angiogenesis |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-109704 | PI3K Cascade |
| reactome | R-HSA-112399 | IRS-mediated signalling |
| reactome | R-HSA-112399 | IRS-mediated signalling |
| reactome | R-HSA-112412 | SOS-mediated signalling |
| reactome | R-HSA-112412 | SOS-mediated signalling |
| reactome | R-HSA-1226099 | Signaling by FGFR in disease |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants |
| reactome | R-HSA-1236394 | Signaling by ERBB4 |
| reactome | R-HSA-1250196 | SHC1 events in ERBB2 signaling |
| reactome | R-HSA-1250347 | SHC1 events in ERBB4 signaling |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1295596 | Spry regulation of FGF signaling |
| reactome | R-HSA-1433557 | Signaling by SCF-KIT |
| reactome | R-HSA-1433559 | Regulation of KIT signaling |
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1643713 | Signaling by EGFR in Cancer |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-167044 | Signalling to RAS |
| reactome | R-HSA-167044 | Signalling to RAS |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-177929 | Signaling by EGFR |
| reactome | R-HSA-179812 | GRB2 events in EGFR signaling |
| reactome | R-HSA-180292 | GAB1 signalosome |
| reactome | R-HSA-180336 | SHC1 events in EGFR signaling |
| reactome | R-HSA-182971 | EGFR downregulation |
| reactome | R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants |
| reactome | R-HSA-1839124 | FGFR1 mutant receptor activation |
| reactome | R-HSA-186763 | Downstream signal transduction |
| reactome | R-HSA-186797 | Signaling by PDGF |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-187687 | Signalling to ERKs |
| reactome | R-HSA-187687 | Signalling to ERKs |
| reactome | R-HSA-190236 | Signaling by FGFR |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-1963640 | GRB2 events in ERBB2 signaling |
| reactome | R-HSA-1963640 | GRB2 events in ERBB2 signaling |
| reactome | R-HSA-1963642 | PI3K events in ERBB2 signaling |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation |
| reactome | R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation |
| reactome | R-HSA-210993 | Tie2 Signaling |
| reactome | R-HSA-2172127 | DAP12 interactions |
| reactome | R-HSA-2179392 | EGFR Transactivation by Gastrin |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer |
| reactome | R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| reactome | R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| reactome | R-HSA-2424491 | DAP12 signaling |
| reactome | R-HSA-2428924 | IGF1R signaling cascade |
| reactome | R-HSA-2428924 | IGF1R signaling cascade |
| reactome | R-HSA-2428928 | IRS-related events triggered by IGF1R |
| reactome | R-HSA-2428928 | IRS-related events triggered by IGF1R |
| reactome | R-HSA-2428933 | SHC-related events triggered by IGF1R |
| reactome | R-HSA-2428933 | SHC-related events triggered by IGF1R |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization |
| reactome | R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization |
| reactome | R-HSA-2871796 | FCERI mediated MAPK activation |
| reactome | R-HSA-2871809 | FCERI mediated Ca+2 mobilization |
| reactome | R-HSA-2871809 | FCERI mediated Ca+2 mobilization |
| reactome | R-HSA-354192 | Integrin alphaIIb beta3 signaling |
| reactome | R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-375165 | NCAM signaling for neurite out-growth |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-388841 | Costimulation by the CD28 family |
| reactome | R-HSA-389356 | CD28 co-stimulation |
| reactome | R-HSA-389359 | CD28 dependent Vav1 pathway |
| reactome | R-HSA-391160 | Signal regulatory protein family interactions |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-451927 | Interleukin-2 family signaling |
| reactome | R-HSA-451927 | Interleukin-2 family signaling |
| reactome | R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| reactome | R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| reactome | R-HSA-5637810 | Constitutive Signaling by EGFRvIII |
| reactome | R-HSA-5637812 | Signaling by EGFRvIII in Cancer |
| reactome | R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5654687 | Downstream signaling of activated FGFR1 |
| reactome | R-HSA-5654688 | SHC-mediated cascade:FGFR1 |
| reactome | R-HSA-5654689 | PI-3K cascade:FGFR1 |
| reactome | R-HSA-5654693 | FRS-mediated FGFR1 signaling |
| reactome | R-HSA-5654695 | PI-3K cascade:FGFR2 |
| reactome | R-HSA-5654696 | Downstream signaling of activated FGFR2 |
| reactome | R-HSA-5654699 | SHC-mediated cascade:FGFR2 |
| reactome | R-HSA-5654700 | FRS-mediated FGFR2 signaling |
| reactome | R-HSA-5654704 | SHC-mediated cascade:FGFR3 |
| reactome | R-HSA-5654706 | FRS-mediated FGFR3 signaling |
| reactome | R-HSA-5654708 | Downstream signaling of activated FGFR3 |
| reactome | R-HSA-5654710 | PI-3K cascade:FGFR3 |
| reactome | R-HSA-5654712 | FRS-mediated FGFR4 signaling |
| reactome | R-HSA-5654716 | Downstream signaling of activated FGFR4 |
| reactome | R-HSA-5654719 | SHC-mediated cascade:FGFR4 |
| reactome | R-HSA-5654720 | PI-3K cascade:FGFR4 |
| reactome | R-HSA-5654726 | Negative regulation of FGFR1 signaling |
| reactome | R-HSA-5654727 | Negative regulation of FGFR2 signaling |
| reactome | R-HSA-5654732 | Negative regulation of FGFR3 signaling |
| reactome | R-HSA-5654733 | Negative regulation of FGFR4 signaling |
| reactome | R-HSA-5654736 | Signaling by FGFR1 |
| reactome | R-HSA-5654738 | Signaling by FGFR2 |
| reactome | R-HSA-5654741 | Signaling by FGFR3 |
| reactome | R-HSA-5654743 | Signaling by FGFR4 |
| reactome | R-HSA-5655253 | Signaling by FGFR2 in disease |
| reactome | R-HSA-5655291 | Signaling by FGFR4 in disease |
| reactome | R-HSA-5655302 | Signaling by FGFR1 in disease |
| reactome | R-HSA-5655332 | Signaling by FGFR3 in disease |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-5663213 | RHO GTPases Activate WASPs and WAVEs |
| reactome | R-HSA-5663213 | RHO GTPases Activate WASPs and WAVEs |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6806834 | Signaling by MET |
| reactome | R-HSA-6807004 | Negative regulation of MET activity |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-74749 | Signal attenuation |
| reactome | R-HSA-74751 | Insulin receptor signalling cascade |
| reactome | R-HSA-74751 | Insulin receptor signalling cascade |
| reactome | R-HSA-74752 | Signaling by Insulin receptor |
| reactome | R-HSA-74752 | Signaling by Insulin receptor |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76009 | Platelet Aggregation (Plug Formation) |
| reactome | R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK |
| reactome | R-HSA-8851805 | MET activates RAS signaling |
| reactome | R-HSA-8851907 | MET activates PI3K/AKT signaling |
| reactome | R-HSA-8853334 | Signaling by FGFR3 fusions in cancer |
| reactome | R-HSA-8853338 | Signaling by FGFR3 point mutants in cancer |
| reactome | R-HSA-8853659 | RET signaling |
| reactome | R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
| reactome | R-HSA-8865999 | MET activates PTPN11 |
| reactome | R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell |
| reactome | R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell |
| reactome | R-HSA-8875555 | MET activates RAP1 and RAC1 |
| reactome | R-HSA-8875656 | MET receptor recycling |
| reactome | R-HSA-8875878 | MET promotes cell motility |
| reactome | R-HSA-8876384 | Listeria monocytogenes entry into host cells |
| reactome | R-HSA-8876384 | Listeria monocytogenes entry into host cells |
| reactome | R-HSA-8983432 | Interleukin-15 signaling |
| reactome | R-HSA-8983432 | Interleukin-15 signaling |
| reactome | R-HSA-9006115 | Signaling by NTRK2 (TRKB) |
| reactome | R-HSA-9006115 | Signaling by NTRK2 (TRKB) |
| reactome | R-HSA-9006921 | Integrin signaling |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9026519 | Activated NTRK2 signals through RAS |
| reactome | R-HSA-9028335 | Activated NTRK2 signals through PI3K |
| reactome | R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 |
| reactome | R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 |
| reactome | R-HSA-9034015 | Signaling by NTRK3 (TRKC) |
| reactome | R-HSA-9034864 | Activated NTRK3 signals through RAS |
| reactome | R-HSA-912526 | Interleukin receptor SHC signaling |
| reactome | R-HSA-912631 | Regulation of signaling by CBL |
| reactome | R-HSA-912631 | Regulation of signaling by CBL |
| reactome | R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| smpdb | SMP00358 | Fc Epsilon Receptor I Signaling in Mast Cells |
| smpdb | SMP00391 | Insulin Signalling |
| wikipathways | WP127 | IL-5 Signaling Pathway |
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP1993 | Angiogenesis overview |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP22 | IL-9 Signaling Pathway |
| wikipathways | WP2253 | Pilocytic astrocytoma |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP2263 | Androgen Receptor Network in Prostate Cancer |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP2332 | Interleukin-11 Signaling Pathway |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP244 | Alpha 6 Beta 4 signaling pathway |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP286 | IL-3 Signaling Pathway |
| wikipathways | WP304 | Kit receptor signaling pathway |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP313 | Signaling of Hepatocyte Growth Factor Receptor |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP364 | IL-6 signaling pathway |
| wikipathways | WP3646 | Hepatitis C and Hepatocellular Carcinoma |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP3676 | BDNF-TrkB Signaling |
| wikipathways | WP3680 | Association Between Physico-Chemical Features and Toxicity Associated Pathways |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3863 | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP395 | IL-4 Signaling Pathway |
| wikipathways | WP3972 | PDGFR-beta pathway |
| wikipathways | WP3981 | miRNA regulation of prostate cancer signaling pathways |
| wikipathways | WP400 | p38 MAPK Signaling Pathway |
| wikipathways | WP4155 | Endometrial cancer |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4205 | MET in type 1 papillary renal cell carcinoma |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP49 | IL-2 Signaling Pathway |
| wikipathways | WP581 | EPO Receptor Signaling |
| wikipathways | WP673 | ErbB Signaling Pathway |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| pid | a6b1_a6b4_integrin_pathway | a6b1 and a6b4 Integrin signaling |
| pid | angiopoietinreceptor_pathway | Angiopoietin receptor Tie2-mediated signaling |
| pid | bcr_5pathway | BCR signaling pathway |
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | epha2_fwdpathway | EPHA2 forward signaling |
| pid | ephbfwdpathway | EPHB forward signaling |
| pid | epopathway | EPO signaling pathway |
| pid | er_nongenomic_pathway | Plasma membrane estrogen receptor signaling |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | erbb1_internalization_pathway | Internalization of ErbB1 |
| pid | erbb2erbb3pathway | ErbB2/ErbB3 signaling events |
| pid | erbb4_pathway | ErbB4 signaling events |
| pid | et_egfrpathway | EGFR-dependent Endothelin signaling events |
| pid | fak_pathway | Signaling events mediated by focal adhesion kinase |
| pid | fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| pid | fgf_pathway | FGF signaling pathway |
| pid | gmcsf_pathway | GMCSF-mediated signaling events |
| pid | igf1_pathway | IGF1 pathway |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | il2_pi3kpathway | IL2 signaling events mediated by PI3K |
| pid | il2_stat5pathway | IL2 signaling events mediated by STAT5 |
| pid | il3_pathway | IL3-mediated signaling events |
| pid | il4_2pathway | IL4-mediated signaling events |
| pid | il5_pathway | IL5-mediated signaling events |
| pid | il6_7pathway | IL6-mediated signaling events |
| pid | insulin_pathway | Insulin Pathway |
| pid | kitpathway | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| pid | lymphangiogenesis_pathway | VEGFR3 signaling in lymphatic endothelium |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| pid | nephrin_neph1_pathway | Nephrin/Neph1 signaling in the kidney podocyte |
| pid | pdgfrapathway | PDGFR-alpha signaling pathway |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | pi3kplctrkpathway | Trk receptor signaling mediated by PI3K and PLC-gamma |
| pid | ptp1bpathway | Signaling events mediated by PTP1B |
| pid | ras_pathway | Regulation of Ras family activation |
| pid | ret_pathway | Signaling events regulated by Ret tyrosine kinase |
| pid | shp2_pathway | SHP2 signaling |
| pid | tcptp_pathway | Signaling events mediated by TCPTP |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| pid | tgfbrpathway | TGF-beta receptor signaling |
| pid | trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
| pid | vegfr1_2_pathway | Signaling events mediated by VEGFR1 and VEGFR2 |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD137 | Indisulam | 5 |
| iGMDRD474 | Avrainvillamide | 6 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD318 | PAC-1 | 6 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD341 | Triacsin c | 6 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD886 | Compound 1541A | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GRB2
CLASSFICATION
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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.