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PDCD11

Summary: PDCD11 is a NF-kappa-B (NFKB1; 164011)-binding protein that colocalizes with U3 RNA (MIM 180710) in the nucleolus and is required for rRNA maturation and generation of 18S rRNA (Sweet et al., 2003 [PubMed 14624448]; Sweet et al., 2008 [PubMed 17654514]).[supplied by OMIM, Oct 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameprogrammed cell death 11 OMIM IDMIM:612333 Ensembl IDEnsembl:ENSG00000148843 HGNC IDHGNC:HGNC:13408 PHARMGKB IDPA134909758 Map Location10q24.33

Gene Categories:

TRANSCRIPTION FACTOR BINDING

GO terms in PDCD11

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	TAS	GO:0006364	rRNA processing
BP	IEA	GO:0006397	mRNA processing
CC	IDA	GO:0005634	nucleus
CC	TAS	GO:0005654	nucleoplasm
CC	IBA	GO:0005730	nucleolus
CC	IEA	GO:0005829	cytosol

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Gene expression in normal tissue: PDCD11

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PDCD11

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-6790901	rRNA modification in the nucleus and cytosol
reactome	R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol
reactome	R-HSA-72312	rRNA processing
reactome	R-HSA-72312	rRNA processing
reactome	R-HSA-8868773	rRNA processing in the nucleus and cytosol
reactome	R-HSA-8868773	rRNA processing in the nucleus and cytosol

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD79	Gemcitabine	4
iGMDRD424	Tamatinib	2
iGMDRD150	RITA	3
iGMDRD84	Lovastatin acid	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PDCD11

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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