PDCD11
Summary: PDCD11 is a NF-kappa-B (NFKB1; 164011)-binding protein that colocalizes with U3 RNA (MIM 180710) in the nucleolus and is required for rRNA maturation and generation of 18S rRNA (Sweet et al., 2003 [PubMed 14624448]; Sweet et al., 2008 [PubMed 17654514]).[supplied by OMIM, Oct 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| programmed cell death 11 | MIM:612333 | Ensembl:ENSG00000148843 | HGNC:HGNC:13408 | PA134909758 | 10q24.33 |
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in PDCD11
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006364 | rRNA processing |
| BP | IEA | GO:0006397 | mRNA processing |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005730 | nucleolus |
| CC | IEA | GO:0005829 | cytosol |
| CC | IBA | GO:0032040 | small-subunit processome |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
Gene expression in normal tissue: PDCD11
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PDCD11
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-6790901 | rRNA modification in the nucleus and cytosol |
| reactome | R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol |
| reactome | R-HSA-72312 | rRNA processing |
| reactome | R-HSA-72312 | rRNA processing |
| reactome | R-HSA-8868773 | rRNA processing in the nucleus and cytosol |
| reactome | R-HSA-8868773 | rRNA processing in the nucleus and cytosol |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-8953854 | Metabolism of RNA |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD79 | Gemcitabine | 4 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD150 | RITA | 3 |
| iGMDRD84 | Lovastatin acid | 1 |
| iGMDRD945 | ML214 | 1 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 6 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD267 | Oligomycin A | 4 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD121 | GMX1778 | 6 |
| iGMDRD137 | Indisulam | 4 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD552 | AZD-1775 | 2 |
| iGMDRD300 | Tozasertib | 6 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD871 | BRD6368 | 4 |
| iGMDRD781 | Sirolimus | 6 |
| iGMDRD484 | Pluripotin | 2 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD126 | Tipifarnib | 5 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD61 | Kinetin riboside | 6 |
| iGMDRD107 | Valdecoxib | 3 |
| iGMDRD201 | SKI II | 3 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD318 | PAC-1 | 5 |
| iGMDRD260 | FQI-2 | 2 |
| iGMDRD802 | 4-methylfasudil | 2 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD513 | BML-259 | 2 |
| iGMDRD451 | Serdemetan | 1 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD23 | Gossypol | 5 |
| iGMDRD640 | CAY10618 | 1 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD888 | Compound 44 | 2 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD100 | Zebularine | 5 |
| iGMDRD188 | Piperlongumine | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PDCD11
CLASSFICATION
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