NUP153


Summary: Nuclear pore complexes regulate the transport of macromolecules between the nucleus and cytoplasm. They are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are glycoproteins found in nuclear pores and contain characteristic pentapeptide XFXFG repeats as well as O-linked N-acetylglucosamine residues oriented towards the cytoplasm. The protein encoded by this gene has three distinct domains: a N-terminal region containing a pore targeting and an RNA-binding domain domain, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
nucleoporin 153MIM:603948Ensembl:ENSG00000124789HGNC:HGNC:8062PA318486p22.3

GO terms in NUP153


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005643nuclear pore
CCTASGO:0005654nucleoplasm
CCIDAGO:0005730nucleolus
CCIDAGO:0005829cytosol
CCIDAGO:0031965nuclear membrane
CCIDAGO:0034399nuclear periphery
CCIDAGO:0042405nuclear inclusion body
CCIEAGO:0043657host cell
CCIBAGO:0044613nuclear pore central transport channel
CCIBAGO:0044615nuclear pore nuclear basket
CCIDAGO:0044615nuclear pore nuclear basket
BPIBAGO:0006405RNA export from nucleus
BPTASGO:0006406mRNA export from nucleus
BPIBAGO:0006606protein import into nucleus
BPTASGO:0016032viral process
BPIEAGO:0046718viral entry into host cell
BPIDAGO:0046832negative regulation of RNA export from nucleus
BPIMPGO:0051292nuclear pore complex assembly
BPIEAGO:0075732viral penetration into host nucleus
MFIEAGO:0003677DNA binding
MFIPIGO:0005515protein binding
MFIBAGO:0008139nuclear localization sequence binding
MFIBAGO:0017056structural constituent of nuclear pore
MFIDAGO:0017056structural constituent of nuclear pore
MFIMPGO:0017056structural constituent of nuclear pore
MFIPIGO:0042802identical protein binding
MFIMPGO:0043495protein membrane anchor
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: NUP153

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NUP153


DatabasePathway IDPathway Des.
reactomeR-HSA-1169408ISG15 antiviral mechanism
reactomeR-HSA-1169410Antiviral mechanism by IFN-stimulated genes
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-159227Transport of the SLBP independent Mature mRNA
reactomeR-HSA-159230Transport of the SLBP Dependant Mature mRNA
reactomeR-HSA-159231Transport of Mature mRNA Derived from an Intronless Transcript
reactomeR-HSA-159234Transport of Mature mRNAs Derived from Intronless Transcripts
reactomeR-HSA-159236Transport of Mature mRNA derived from an Intron-Containing Transcript
reactomeR-HSA-162587HIV Life Cycle
reactomeR-HSA-162599Late Phase of HIV Life Cycle
reactomeR-HSA-162906HIV Infection
reactomeR-HSA-162906HIV Infection
reactomeR-HSA-162909Host Interactions of HIV factors
reactomeR-HSA-162909Host Interactions of HIV factors
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1643685Disease
reactomeR-HSA-1643685Disease
reactomeR-HSA-165054Rev-mediated nuclear export of HIV RNA
reactomeR-HSA-168253Host Interactions with Influenza Factors
reactomeR-HSA-168254Influenza Infection
reactomeR-HSA-168255Influenza Life Cycle
reactomeR-HSA-168256Immune System
reactomeR-HSA-168271Transport of Ribonucleoproteins into the Host Nucleus
reactomeR-HSA-168273Influenza Viral RNA Transcription and Replication
reactomeR-HSA-168274Export of Viral Ribonucleoproteins from Nucleus
reactomeR-HSA-168276NS1 Mediated Effects on Host Pathways
reactomeR-HSA-168325Viral Messenger RNA Synthesis
reactomeR-HSA-168333NEP/NS2 Interacts with the Cellular Export Machinery
reactomeR-HSA-170822Regulation of Glucokinase by Glucokinase Regulatory Protein
reactomeR-HSA-176033Interactions of Vpr with host cellular proteins
reactomeR-HSA-177243Interactions of Rev with host cellular proteins
reactomeR-HSA-177243Interactions of Rev with host cellular proteins
reactomeR-HSA-180746Nuclear import of Rev protein
reactomeR-HSA-180910Vpr-mediated nuclear import of PICs
reactomeR-HSA-191859snRNP Assembly
reactomeR-HSA-194441Metabolism of non-coding RNA
reactomeR-HSA-211000Gene Silencing by RNA
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2980766Nuclear Envelope Breakdown
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-3108214SUMOylation of DNA damage response and repair proteins
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-3232142SUMOylation of ubiquitinylation proteins
reactomeR-HSA-3301854Nuclear Pore Complex (NPC) Disassembly
reactomeR-HSA-3371453Regulation of HSF1-mediated heat shock response
reactomeR-HSA-3371556Cellular response to heat stress
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-4085377SUMOylation of SUMOylation proteins
reactomeR-HSA-4551638SUMOylation of chromatin organization proteins
reactomeR-HSA-4570464SUMOylation of RNA binding proteins
reactomeR-HSA-4615885SUMOylation of DNA replication proteins
reactomeR-HSA-4615885SUMOylation of DNA replication proteins
reactomeR-HSA-5578749Transcriptional regulation by small RNAs
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6784531tRNA processing in the nucleus
reactomeR-HSA-68875Mitotic Prophase
reactomeR-HSA-68886M Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-70171Glycolysis
reactomeR-HSA-70326Glucose metabolism
reactomeR-HSA-71387Metabolism of carbohydrates
reactomeR-HSA-72202Transport of Mature Transcript to Cytoplasm
reactomeR-HSA-72203Processing of Capped Intron-Containing Pre-mRNA
reactomeR-HSA-72306tRNA processing
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8953854Metabolism of RNA
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-913531Interferon Signaling
biocartanpcpathwaymechanism of protein import into the nucleus
biocartaranbp2pathwaysumoylation by ranbp2 regulates transcriptional repression
biocartaranpathwaycycling of ran in nucleocytoplasmic transport
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
pidhdac_classi_pathwaySignaling events mediated by HDAC Class I
pidhdac_classii_pathwaySignaling events mediated by HDAC Class II
pidranbp2pathwaySumoylation by RanBP2 regulates transcriptional repression
pidsmad2_3pathwayRegulation of cytoplasmic and nuclear SMAD2/3 signaling
kegghsa03013RNA transport - Homo sapiens (human)
wikipathwaysWP366TGF-beta Signaling Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD607Ubistatin B3
iGMDRD512nutlin 32
iGMDRD701NVP-AUY9222
iGMDRD116CD4374
iGMDRD351GW843682X2
iGMDRD219Bax channel blocker3
iGMDRD123Isoevodiamine2
iGMDRD121GMX17781
iGMDRD158NSC1415402
iGMDRD213SMR0000686503
iGMDRD705Nakiterpiosin2
iGMDRD434BMS-5369246
iGMDRD329Merck603
iGMDRD286Nsc 6328392
iGMDRD367Ro 28-16752
iGMDRD871BRD63682
iGMDRD414MST-3122
iGMDRD872BRD71375
iGMDRD82Quiflapon2
iGMDRD322FK 8662
iGMDRD300Tozasertib5
iGMDRD505Pevonedistat3
iGMDRD552AZD-17752
iGMDRD772BRD47703
iGMDRD579PF7503
iGMDRD151CHM-12
iGMDRD427ABT7372
iGMDRD546BMS-7548072
iGMDRD61Kinetin riboside2
iGMDRD446LY 21832406
iGMDRD71Sparfosic acid3
iGMDRD380Pifithrin-alpha3
iGMDRD297Austocystin D2
iGMDRD280CYTOCHALASIN B3
iGMDRD8024-methylfasudil5
iGMDRD247Blebbistatin6
iGMDRD513BML-2591
iGMDRD474Avrainvillamide5
iGMDRD8012,4-dideoxy-DC-45-A23
iGMDRD318PAC-13
iGMDRD171Pemetrexed3
iGMDRD506Fedratinib5
iGMDRD562Navitoclax5
iGMDRD100Zebularine3
iGMDRD188Piperlongumine8
iGMDRD887Compound 23 citrate1
iGMDRD399Selumetinib3
iGMDRD74Idarubicin3
iGMDRD23Gossypol3
iGMDRD356PNU-746542
iGMDRD268Cerulenin3
iGMDRD451Serdemetan2
iGMDRD690PRIMA-1MET3
iGMDRD60Quinoclamine3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NUP153

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