NUP153
Summary: Nuclear pore complexes regulate the transport of macromolecules between the nucleus and cytoplasm. They are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are glycoproteins found in nuclear pores and contain characteristic pentapeptide XFXFG repeats as well as O-linked N-acetylglucosamine residues oriented towards the cytoplasm. The protein encoded by this gene has three distinct domains: a N-terminal region containing a pore targeting and an RNA-binding domain domain, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nucleoporin 153 | MIM:603948 | Ensembl:ENSG00000124789 | HGNC:HGNC:8062 | PA31848 | 6p22.3 |
GO terms in NUP153
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005643 | nuclear pore |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0031965 | nuclear membrane |
| CC | IDA | GO:0034399 | nuclear periphery |
| CC | IDA | GO:0042405 | nuclear inclusion body |
| CC | IEA | GO:0043657 | host cell |
| CC | IBA | GO:0044613 | nuclear pore central transport channel |
| CC | IBA | GO:0044615 | nuclear pore nuclear basket |
| CC | IDA | GO:0044615 | nuclear pore nuclear basket |
| BP | IBA | GO:0006405 | RNA export from nucleus |
| BP | TAS | GO:0006406 | mRNA export from nucleus |
| BP | IBA | GO:0006606 | protein import into nucleus |
| BP | TAS | GO:0016032 | viral process |
| BP | IEA | GO:0046718 | viral entry into host cell |
| BP | IDA | GO:0046832 | negative regulation of RNA export from nucleus |
| BP | IMP | GO:0051292 | nuclear pore complex assembly |
| BP | IEA | GO:0075732 | viral penetration into host nucleus |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008139 | nuclear localization sequence binding |
| MF | IBA | GO:0017056 | structural constituent of nuclear pore |
| MF | IDA | GO:0017056 | structural constituent of nuclear pore |
| MF | IMP | GO:0017056 | structural constituent of nuclear pore |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IMP | GO:0043495 | protein membrane anchor |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: NUP153
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NUP153
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1169408 | ISG15 antiviral mechanism |
| reactome | R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-159227 | Transport of the SLBP independent Mature mRNA |
| reactome | R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA |
| reactome | R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript |
| reactome | R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| reactome | R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| reactome | R-HSA-162587 | HIV Life Cycle |
| reactome | R-HSA-162599 | Late Phase of HIV Life Cycle |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162909 | Host Interactions of HIV factors |
| reactome | R-HSA-162909 | Host Interactions of HIV factors |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-165054 | Rev-mediated nuclear export of HIV RNA |
| reactome | R-HSA-168253 | Host Interactions with Influenza Factors |
| reactome | R-HSA-168254 | Influenza Infection |
| reactome | R-HSA-168255 | Influenza Life Cycle |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus |
| reactome | R-HSA-168273 | Influenza Viral RNA Transcription and Replication |
| reactome | R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus |
| reactome | R-HSA-168276 | NS1 Mediated Effects on Host Pathways |
| reactome | R-HSA-168325 | Viral Messenger RNA Synthesis |
| reactome | R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery |
| reactome | R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein |
| reactome | R-HSA-176033 | Interactions of Vpr with host cellular proteins |
| reactome | R-HSA-177243 | Interactions of Rev with host cellular proteins |
| reactome | R-HSA-177243 | Interactions of Rev with host cellular proteins |
| reactome | R-HSA-180746 | Nuclear import of Rev protein |
| reactome | R-HSA-180910 | Vpr-mediated nuclear import of PICs |
| reactome | R-HSA-191859 | snRNP Assembly |
| reactome | R-HSA-194441 | Metabolism of non-coding RNA |
| reactome | R-HSA-211000 | Gene Silencing by RNA |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2980766 | Nuclear Envelope Breakdown |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108214 | SUMOylation of DNA damage response and repair proteins |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3232142 | SUMOylation of ubiquitinylation proteins |
| reactome | R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly |
| reactome | R-HSA-3371453 | Regulation of HSF1-mediated heat shock response |
| reactome | R-HSA-3371556 | Cellular response to heat stress |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-4085377 | SUMOylation of SUMOylation proteins |
| reactome | R-HSA-4551638 | SUMOylation of chromatin organization proteins |
| reactome | R-HSA-4570464 | SUMOylation of RNA binding proteins |
| reactome | R-HSA-4615885 | SUMOylation of DNA replication proteins |
| reactome | R-HSA-4615885 | SUMOylation of DNA replication proteins |
| reactome | R-HSA-5578749 | Transcriptional regulation by small RNAs |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6784531 | tRNA processing in the nucleus |
| reactome | R-HSA-68875 | Mitotic Prophase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-70171 | Glycolysis |
| reactome | R-HSA-70326 | Glucose metabolism |
| reactome | R-HSA-71387 | Metabolism of carbohydrates |
| reactome | R-HSA-72202 | Transport of Mature Transcript to Cytoplasm |
| reactome | R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA |
| reactome | R-HSA-72306 | tRNA processing |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-913531 | Interferon Signaling |
| biocarta | npcpathway | mechanism of protein import into the nucleus |
| biocarta | ranbp2pathway | sumoylation by ranbp2 regulates transcriptional repression |
| biocarta | ranpathway | cycling of ran in nucleocytoplasmic transport |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| pid | hdac_classi_pathway | Signaling events mediated by HDAC Class I |
| pid | hdac_classii_pathway | Signaling events mediated by HDAC Class II |
| pid | ranbp2pathway | Sumoylation by RanBP2 regulates transcriptional repression |
| pid | smad2_3pathway | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| kegg | hsa03013 | RNA transport - Homo sapiens (human) |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD607 | Ubistatin B | 3 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD116 | CD437 | 4 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD121 | GMX1778 | 1 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD434 | BMS-536924 | 6 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD872 | BRD7137 | 5 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD300 | Tozasertib | 5 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD552 | AZD-1775 | 2 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD446 | LY 2183240 | 6 |
| iGMDRD71 | Sparfosic acid | 3 |
| iGMDRD380 | Pifithrin-alpha | 3 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD802 | 4-methylfasudil | 5 |
| iGMDRD247 | Blebbistatin | 6 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD474 | Avrainvillamide | 5 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD506 | Fedratinib | 5 |
| iGMDRD562 | Navitoclax | 5 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD188 | Piperlongumine | 8 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD268 | Cerulenin | 3 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD690 | PRIMA-1MET | 3 |
| iGMDRD60 | Quinoclamine | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NUP153
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.