NUP153
Summary: Nuclear pore complexes regulate the transport of macromolecules between the nucleus and cytoplasm. They are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are glycoproteins found in nuclear pores and contain characteristic pentapeptide XFXFG repeats as well as O-linked N-acetylglucosamine residues oriented towards the cytoplasm. The protein encoded by this gene has three distinct domains: a N-terminal region containing a pore targeting and an RNA-binding domain domain, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
Namenucleoporin 153 OMIM IDMIM:603948 Ensembl IDEnsembl:ENSG00000124789 HGNC IDHGNC:HGNC:8062 PHARMGKB IDPA31848 Map Location6p22.3 |
GO terms in NUP153
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IDA | GO:0005643 | nuclear pore |
CC | TAS | GO:0005654 | nucleoplasm |
CC | IDA | GO:0005730 | nucleolus |
CC | IDA | GO:0005829 | cytosol |
CC | IDA | GO:0031965 | nuclear membrane |
CC | IDA | GO:0034399 | nuclear periphery |
Gene expression in normal tissue: NUP153
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NUP153
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1169408 | ISG15 antiviral mechanism |
reactome | R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes |
reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-159227 | Transport of the SLBP independent Mature mRNA |
reactome | R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in NUP153
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |