NUP153


Summary: Nuclear pore complexes regulate the transport of macromolecules between the nucleus and cytoplasm. They are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are glycoproteins found in nuclear pores and contain characteristic pentapeptide XFXFG repeats as well as O-linked N-acetylglucosamine residues oriented towards the cytoplasm. The protein encoded by this gene has three distinct domains: a N-terminal region containing a pore targeting and an RNA-binding domain domain, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:603948
PHARMGKB IDPA31848
Map Location6p22.3

GO terms in NUP153


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005643 nuclear pore
CC TAS GO:0005654 nucleoplasm
CC IDA GO:0005730 nucleolus
CC IDA GO:0005829 cytosol
CC IDA GO:0031965 nuclear membrane
CC IDA GO:0034399 nuclear periphery
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Gene expression in normal tissue: NUP153

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined41Apoptosis regulation2One carbon pool by folate1Other, kinases1ERK MAPK signaling1p53 pathway1Biosynthesis of secondary metabolites1IGFR signaling1Protein stability and degradation1Cell cycle1

Pathways in NUP153


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1169408 ISG15 antiviral mechanism
reactome R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes
reactome R-HSA-1280215 Cytokine Signaling in Immune system
reactome R-HSA-1430728 Metabolism
reactome R-HSA-159227 Transport of the SLBP independent Mature mRNA
reactome R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD607 Ubistatin B 3
iGMDRD512 nutlin 3 2
iGMDRD701 NVP-AUY922 2
iGMDRD116 CD437 4
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NUP153

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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