ISG15
Summary: The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:147571 Ensembl IDEnsembl:ENSG00000187608 HGNC IDHGNC:HGNC:4053 PHARMGKB IDPA28465 Map Location1p36.33 | |||||
GO terms in ISG15
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0031386 | protein tag |
| BP | IEA | GO:0016032 | viral process |
| BP | IEA | GO:0019941 | modification-dependent protein catabolic process |
| BP | TAS | GO:0019985 | translesion synthesis |
| BP | ISS | GO:0030501 | positive regulation of bone mineralization |
Gene expression in normal tissue: ISG15
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ISG15
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| reactome | R-HSA-1169408 | ISG15 antiviral mechanism |
| reactome | R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168249 | Innate Immune System |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ISG15
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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