ISG15
Summary: The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ISG15 ubiquitin-like modifier | MIM:147571 | Ensembl:ENSG00000187608 | HGNC:HGNC:4053 | PA28465 | 1p36.33 |
GO terms in ISG15
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0031386 | protein tag |
| BP | IEA | GO:0016032 | viral process |
| BP | IEA | GO:0019941 | modification-dependent protein catabolic process |
| BP | TAS | GO:0019985 | translesion synthesis |
| BP | ISS | GO:0030501 | positive regulation of bone mineralization |
| BP | IDA | GO:0031397 | negative regulation of protein ubiquitination |
| BP | IDA | GO:0032020 | ISG15-protein conjugation |
| BP | IMP | GO:0032020 | ISG15-protein conjugation |
| BP | TAS | GO:0032480 | negative regulation of type I interferon production |
| BP | IMP | GO:0032649 | regulation of interferon-gamma production |
| BP | IDA | GO:0034340 | response to type I interferon |
| BP | IMP | GO:0042742 | defense response to bacterium |
| BP | IMP | GO:0045071 | negative regulation of viral genome replication |
| BP | IEA | GO:0045648 | positive regulation of erythrocyte differentiation |
| BP | IMP | GO:0051607 | defense response to virus |
| BP | TAS | GO:0060337 | type I interferon signaling pathway |
| CC | IDA | GO:0005576 | extracellular region |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005829 | cytosol |
Gene expression in normal tissue: ISG15
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ISG15
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| reactome | R-HSA-1169408 | ISG15 antiviral mechanism |
| reactome | R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168253 | Host Interactions with Influenza Factors |
| reactome | R-HSA-168254 | Influenza Infection |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168276 | NS1 Mediated Effects on Host Pathways |
| reactome | R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| reactome | R-HSA-5656169 | Termination of translesion DNA synthesis |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-73893 | DNA Damage Bypass |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-909733 | Interferon alpha/beta signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
| reactome | R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling |
| wikipathways | WP3865 | RIG-I-like Receptor Signaling |
| wikipathways | WP619 | Type II interferon signaling (IFNG) |
| kegg | hsa04622 | RIG-I-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD6 | AM-580 | 3 |
| iGMDRD267 | Oligomycin A | 4 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD137 | Indisulam | 4 |
| iGMDRD202 | Curcumin | 6 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD414 | MST-312 | 1 |
| iGMDRD871 | BRD6368 | 6 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD405 | PIK-75 | 6 |
| iGMDRD330 | BRD4132 | 6 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD248 | BRD4354 | 4 |
| iGMDRD782 | DC-45-A2 | 1 |
| iGMDRD441 | TW 37 | 6 |
| iGMDRD52 | Rotenone | 6 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD474 | Avrainvillamide | 5 |
| iGMDRD23 | Gossypol | 5 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD562 | Navitoclax | 1 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD427 | ABT737 | 6 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD554 | CHEMBL1434137 | 3 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD420 | Leucascandrolide A | 5 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD718 | Pyrvinium pamoate | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ISG15
CLASSFICATION
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