ILK

Summary: This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameintegrin linked kinase
OMIM IDMIM:602366
Ensembl IDEnsembl:ENSG00000166333
HGNC IDHGNC:HGNC:6040
PHARMGKB IDPA29855
Map Location11p15.4

GO terms in ILK


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0004674 protein serine/threonine kinase activity
MF IDA GO:0004674 protein serine/threonine kinase activity
MF IEA GO:0005178 integrin binding
MF IPI GO:0005515 protein binding
MF IEA GO:0005524 ATP binding
MF IEA GO:0017124 SH3 domain binding
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Gene expression in normal tissue: ILK

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 19BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 7LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 3UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 6

Gene-drug pathway distribution

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Pathways in ILK


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Database
Pathway ID
Pathway Des.
biocarta ptenpathway pten dependent cell cycle arrest and apoptosis
reactome R-HSA-1500931 Cell-Cell communication
reactome R-HSA-446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions
reactome R-HSA-446353 Cell-extracellular matrix interactions
reactome R-HSA-446728 Cell junction organization
wikipathways WP185 Integrin-mediated Cell Adhesion
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD885 Compound 110 3
iGMDRD427 ABT737 1
iGMDRD434 BMS-536924 1
iGMDRD255 SB225002 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ILK

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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