ILK
Summary: This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| integrin linked kinase | MIM:602366 | Ensembl:ENSG00000166333 | HGNC:HGNC:6040 | PA29855 | 11p15.4 |
GO terms in ILK
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IEA | GO:0005178 | integrin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0017124 | SH3 domain binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| CC | IBA | GO:0001725 | stress fiber |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005911 | cell-cell junction |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IBA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0005925 | focal adhesion |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0030017 | sarcomere |
| CC | IEA | GO:0030027 | lamellipodium |
| CC | IDA | GO:0030054 | cell junction |
| CC | IEA | GO:0032991 | protein-containing complex |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | IEA | GO:0043034 | costamere |
| CC | IEA | GO:0043195 | terminal bouton |
| CC | IEA | GO:0043198 | dendritic shaft |
| BP | IBA | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0001658 | branching involved in ureteric bud morphogenesis |
| BP | IMP | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IEA | GO:0001954 | positive regulation of cell-matrix adhesion |
| BP | IEA | GO:0003151 | outflow tract morphogenesis |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006469 | negative regulation of protein kinase activity |
| BP | IEA | GO:0007050 | cell cycle arrest |
| BP | IBA | GO:0007160 | cell-matrix adhesion |
| BP | TAS | GO:0007160 | cell-matrix adhesion |
| BP | IBA | GO:0007229 | integrin-mediated signaling pathway |
| BP | IDA | GO:0007229 | integrin-mediated signaling pathway |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0007569 | cell aging |
| BP | NAS | GO:0008283 | cell proliferation |
| BP | IEA | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0009967 | positive regulation of signal transduction |
| BP | IEA | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process |
| BP | IEA | GO:0010761 | fibroblast migration |
| BP | IEA | GO:0014912 | negative regulation of smooth muscle cell migration |
| BP | IEA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IEA | GO:0021675 | nerve development |
| BP | IEA | GO:0022011 | myelination in peripheral nervous system |
| BP | IEA | GO:0030335 | positive regulation of cell migration |
| BP | IEA | GO:0030513 | positive regulation of BMP signaling pathway |
| BP | IEA | GO:0032288 | myelin assembly |
| BP | IEA | GO:0032956 | regulation of actin cytoskeleton organization |
| BP | IMP | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | TAS | GO:0034329 | cell junction assembly |
| BP | IBA | GO:0034446 | substrate adhesion-dependent cell spreading |
| BP | IMP | GO:0034446 | substrate adhesion-dependent cell spreading |
| BP | IMP | GO:0042327 | positive regulation of phosphorylation |
| BP | IEA | GO:0043406 | positive regulation of MAP kinase activity |
| BP | IEA | GO:0043491 | protein kinase B signaling |
| BP | IEA | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | IEA | GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity |
| BP | IEA | GO:0045663 | positive regulation of myoblast differentiation |
| BP | IEA | GO:0045669 | positive regulation of osteoblast differentiation |
| BP | IEA | GO:0045773 | positive regulation of axon extension |
| BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IEA | GO:0048662 | negative regulation of smooth muscle cell proliferation |
| BP | IEA | GO:0048812 | neuron projection morphogenesis |
| BP | IEA | GO:0050775 | positive regulation of dendrite morphogenesis |
| BP | IEA | GO:0051291 | protein heterooligomerization |
| BP | IEA | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | HMP | GO:0070527 | platelet aggregation |
| BP | IMP | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| BP | IEA | GO:0097435 | supramolecular fiber organization |
| BP | IMP | GO:1901224 | positive regulation of NIK/NF-kappaB signaling |
| BP | IEA | GO:2000178 | negative regulation of neural precursor cell proliferation |
Gene expression in normal tissue: ILK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ILK
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | ptenpathway | pten dependent cell cycle arrest and apoptosis |
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions |
| reactome | R-HSA-446353 | Cell-extracellular matrix interactions |
| reactome | R-HSA-446728 | Cell junction organization |
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP2572 | Primary Focal Segmental Glomerulosclerosis FSGS |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3850 | Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling |
| wikipathways | WP3942 | PPAR signaling pathway |
| wikipathways | WP405 | Eukaryotic Transcription Initiation |
| wikipathways | WP4155 | Endometrial cancer |
| pid | avb3_integrin_pathway | Integrins in angiogenesis |
| pid | avb3_opn_pathway | Osteopontin-mediated events |
| pid | ilk_pathway | Integrin-linked kinase signaling |
| kegg | hsa03320 | PPAR signaling pathway - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa05100 | Bacterial invasion of epithelial cells - Homo sapiens (human) |
| kegg | hsa05213 | Endometrial cancer - Homo sapiens (human) |
| netpath | Pathway_Wnt | Wnt |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD427 | ABT737 | 1 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD126 | Tipifarnib | 6 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD341 | Triacsin c | 1 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD882 | CIL41 | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ILK
CLASSFICATION
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