STAR

Summary: The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namesteroidogenic acute regulatory protein
OMIM IDMIM:600617
Ensembl IDEnsembl:ENSG00000147465
HGNC IDHGNC:HGNC:11359
PHARMGKB IDPA36181
Map Location8p11.23

GO terms in STAR


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0005758 mitochondrial intermembrane space
CC IEA GO:0005829 cytosol
CC IEA GO:0030061 mitochondrial crista
CC IEA GO:0043005 neuron projection
CC IEA GO:0043025 neuronal cell body
BP IBA GO:0006694 steroid biosynthetic process
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Gene expression in normal tissue: STAR

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined27ERK MAPK signaling2Apoptosis regulation2DNA replication2Longevity regulating pathway1Cell cycle1PI3K/MTOR signaling1Purine metabolism1

Pathways in STAR


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Database
Pathway ID
Pathway Des.
wikipathways WP2355 Corticotropin-releasing hormone signaling pathway
kegg hsa04913 Ovarian steroidogenesis - Homo sapiens (human)
kegg hsa04925 Aldosterone synthesis and secretion - Homo sapiens (human)
kegg hsa04927 Cortisol synthesis and secretion - Homo sapiens (human)
kegg hsa04934 Cushing,s syndrome - Homo sapiens (human)
kegg hsa04979 Cholesterol metabolism - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD148 Pifithrin-mu 3
iGMDRD560 MK-2206 2
iGMDRD79 Gemcitabine 4
iGMDRD57 Chloropentafluorobenzene 5
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STAR

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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