STAR
Summary: The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| steroidogenic acute regulatory protein | MIM:600617 | Ensembl:ENSG00000147465 | HGNC:HGNC:11359 | PA36181 | 8p11.23 |
GO terms in STAR
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005758 | mitochondrial intermembrane space |
| CC | IEA | GO:0005829 | cytosol |
| CC | IEA | GO:0030061 | mitochondrial crista |
| CC | IEA | GO:0043005 | neuron projection |
| CC | IEA | GO:0043025 | neuronal cell body |
| BP | IBA | GO:0006694 | steroid biosynthetic process |
| BP | TAS | GO:0006694 | steroid biosynthetic process |
| BP | IEA | GO:0006699 | bile acid biosynthetic process |
| BP | TAS | GO:0006700 | C21-steroid hormone biosynthetic process |
| BP | IEA | GO:0006703 | estrogen biosynthetic process |
| BP | IEA | GO:0007420 | brain development |
| BP | IEA | GO:0007584 | response to nutrient |
| BP | IEA | GO:0008203 | cholesterol metabolic process |
| BP | IEA | GO:0008211 | glucocorticoid metabolic process |
| BP | IEA | GO:0008584 | male gonad development |
| BP | IEA | GO:0009635 | response to herbicide |
| BP | IEA | GO:0010212 | response to ionizing radiation |
| BP | IEA | GO:0010288 | response to lead ion |
| BP | IEA | GO:0010628 | positive regulation of gene expression |
| BP | IEA | GO:0014823 | response to activity |
| BP | IEA | GO:0016101 | diterpenoid metabolic process |
| BP | IEA | GO:0017143 | insecticide metabolic process |
| BP | IEA | GO:0018879 | biphenyl metabolic process |
| BP | IEA | GO:0018894 | dibenzo-p-dioxin metabolic process |
| BP | IEA | GO:0018958 | phenol-containing compound metabolic process |
| BP | IEA | GO:0018963 | phthalate metabolic process |
| BP | IEA | GO:0032367 | intracellular cholesterol transport |
| BP | IEA | GO:0032869 | cellular response to insulin stimulus |
| BP | IEA | GO:0035094 | response to nicotine |
| BP | IEA | GO:0035457 | cellular response to interferon-alpha |
| BP | IEA | GO:0042542 | response to hydrogen peroxide |
| BP | IEA | GO:0042747 | circadian sleep/wake cycle, REM sleep |
| BP | IEA | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | IEA | GO:0043627 | response to estrogen |
| BP | IEA | GO:0044321 | response to leptin |
| BP | IEA | GO:0044344 | cellular response to fibroblast growth factor stimulus |
| BP | IEA | GO:0045471 | response to ethanol |
| BP | IEA | GO:0048168 | regulation of neuronal synaptic plasticity |
| BP | IEA | GO:0050769 | positive regulation of neurogenesis |
| BP | IEA | GO:0051412 | response to corticosterone |
| BP | IEA | GO:0060992 | response to fungicide |
| BP | IEA | GO:0061370 | testosterone biosynthetic process |
| BP | IDA | GO:0070859 | positive regulation of bile acid biosynthetic process |
| BP | IEA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IEA | GO:0071236 | cellular response to antibiotic |
| BP | IEA | GO:0071276 | cellular response to cadmium ion |
| BP | IEA | GO:0071312 | cellular response to alkaloid |
| BP | IEA | GO:0071320 | cellular response to cAMP |
| BP | IEA | GO:0071333 | cellular response to glucose stimulus |
| BP | IEA | GO:0071346 | cellular response to interferon-gamma |
| BP | IEA | GO:0071372 | cellular response to follicle-stimulating hormone stimulus |
| BP | IEA | GO:0071373 | cellular response to luteinizing hormone stimulus |
| BP | IEA | GO:0071378 | cellular response to growth hormone stimulus |
| BP | IEA | GO:0071549 | cellular response to dexamethasone stimulus |
| BP | IEA | GO:0071560 | cellular response to transforming growth factor beta stimulus |
| BP | IEA | GO:0071872 | cellular response to epinephrine stimulus |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0015485 | cholesterol binding |
| MF | IEA | GO:0017127 | cholesterol transporter activity |
Gene expression in normal tissue: STAR
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STAR
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| kegg | hsa04913 | Ovarian steroidogenesis - Homo sapiens (human) |
| kegg | hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| kegg | hsa04927 | Cortisol synthesis and secretion - Homo sapiens (human) |
| kegg | hsa04934 | Cushing,s syndrome - Homo sapiens (human) |
| kegg | hsa04979 | Cholesterol metabolism - Homo sapiens (human) |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-196071 | Metabolism of steroid hormones |
| reactome | R-HSA-196108 | Pregnenolone biosynthesis |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-8957322 | Metabolism of steroids |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD79 | Gemcitabine | 4 |
| iGMDRD57 | Chloropentafluorobenzene | 5 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD177 | Teniposide | 4 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD158 | NSC141540 | 4 |
| iGMDRD271 | Brefeldin A | 2 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD6 | AM-580 | 6 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD329 | Merck60 | 4 |
| iGMDRD505 | Pevonedistat | 5 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD480 | KU0060648 | 2 |
| iGMDRD260 | FQI-2 | 3 |
| iGMDRD782 | DC-45-A2 | 5 |
| iGMDRD318 | PAC-1 | 6 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD60 | Quinoclamine | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STAR
CLASSFICATION
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