RIPK3
Summary: The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| receptor interacting serine/threonine kinase 3 | MIM:605817 | Ensembl:ENSG00000129465 | HGNC:HGNC:10021 | PA34396 | 14q12 |
GO terms in RIPK3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0003713 | transcription coactivator activity |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IMP | GO:0004672 | protein kinase activity |
| MF | ISS | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IEA | GO:0004704 | NF-kappaB-inducing kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IMP | GO:0044877 | protein-containing complex binding |
| BP | ISS | GO:0001914 | regulation of T cell mediated cytotoxicity |
| BP | ISS | GO:0002819 | regulation of adaptive immune response |
| BP | TAS | GO:0006464 | cellular protein modification process |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | IMP | GO:0010922 | positive regulation of phosphatase activity |
| BP | IMP | GO:0032147 | activation of protein kinase activity |
| BP | ISS | GO:0032649 | regulation of interferon-gamma production |
| BP | ISS | GO:0033077 | T cell differentiation in thymus |
| BP | IEA | GO:0038061 | NIK/NF-kappaB signaling |
| BP | ISS | GO:0043029 | T cell homeostasis |
| BP | ISS | GO:0046006 | regulation of activated T cell proliferation |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | ISS | GO:0048535 | lymph node development |
| BP | ISS | GO:0048536 | spleen development |
| BP | ISS | GO:0048538 | thymus development |
| BP | IDA | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IDA | GO:0051260 | protein homooligomerization |
| BP | IMP | GO:0051291 | protein heterooligomerization |
| BP | IEA | GO:0051351 | positive regulation of ligase activity |
| BP | IEA | GO:0051353 | positive regulation of oxidoreductase activity |
| BP | IDA | GO:0060545 | positive regulation of necroptotic process |
| BP | IMP | GO:0060545 | positive regulation of necroptotic process |
| BP | ISS | GO:0070235 | regulation of activation-induced cell death of T cells |
| BP | IMP | GO:0070266 | necroptotic process |
| BP | TAS | GO:0070266 | necroptotic process |
| BP | TAS | GO:0097190 | apoptotic signaling pathway |
| BP | IEA | GO:1903508 | positive regulation of nucleic acid-templated transcription |
| BP | IMP | GO:1990000 | amyloid fibril formation |
| BP | IEA | GO:2000379 | positive regulation of reactive oxygen species metabolic process |
| BP | ISS | GO:2000452 | regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation |
| BP | IEA | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005886 | plasma membrane |
Gene expression in normal tissue: RIPK3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RIPK3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP2513 | Nanoparticle triggered regulated necrosis |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04623 | Cytosolic DNA-sensing pathway - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| netpath | Pathway_TNFalpha | TNFalpha |
| reactome | R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment |
| reactome | R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 |
| reactome | R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA |
| reactome | R-HSA-2562578 | TRIF-mediated programmed cell death |
| reactome | R-HSA-2672351 | Stimuli-sensing channels |
| reactome | R-HSA-3295583 | TRP channels |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-5213460 | RIPK1-mediated regulated necrosis |
| reactome | R-HSA-5218859 | Regulated Necrosis |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death |
| reactome | R-HSA-937041 | IKK complex recruitment mediated by RIP1 |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-983712 | Ion channel transport |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD126 | Tipifarnib | 5 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD85 | Ursolic acid | 4 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD177 | Teniposide | 1 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD511 | CHEMBL399379 | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD480 | KU0060648 | 3 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD318 | PAC-1 | 6 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD562 | Navitoclax | 4 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD369 | TGX-115 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RIPK3
CLASSFICATION
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