FBN2


Summary: The protein encoded by this gene is a component of connective tissue microfibrils and may be involved in elastic fiber assembly. Mutations in this gene cause congenital contractural arachnodactyly. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
fibrillin 2MIM:612570Ensembl:ENSG00000138829HGNC:HGNC:3604PA280175q23.3

Gene Categories:

DRUGGABLE GENOME

GO terms in FBN2


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0001527microfibril
CCTASGO:0001527microfibril
CCTASGO:0005576extracellular region
CCHDAGO:0031012extracellular matrix
CCIBAGO:0031012extracellular matrix
BPIBAGO:0009653anatomical structure morphogenesis
BPTASGO:0030198extracellular matrix organization
BPIEAGO:0030326embryonic limb morphogenesis
BPISSGO:0030501positive regulation of bone mineralization
BPISSGO:0035583sequestering of TGFbeta in extracellular matrix
BPIEPGO:0043010camera-type eye development
BPISSGO:0045669positive regulation of osteoblast differentiation
BPIEPGO:0048048embryonic eye morphogenesis
BPISSGO:0060346bone trabecula formation
MFIBAGO:0005201extracellular matrix structural constituent
MFIEAGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFICGO:0030023extracellular matrix constituent conferring elasticity

Gene expression in normal tissue: FBN2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FBN2


DatabasePathway IDPathway Des.
reactomeR-HSA-1474228Degradation of the extracellular matrix
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1566948Elastic fibre formation
reactomeR-HSA-1566948Elastic fibre formation
reactomeR-HSA-2129379Molecules associated with elastic fibres
reactomeR-HSA-2129379Molecules associated with elastic fibres
wikipathwaysWP3668Hypothesized Pathways in Pathogenesis of Cardiovascular Disease

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD148Pifithrin-mu3
iGMDRD512nutlin 32
iGMDRD405PIK-752
iGMDRD85Ursolic acid1
iGMDRD351GW843682X7
iGMDRD314Tanespimycin1
iGMDRD132(-)-gallocatechin-3-O-gallate2
iGMDRD945ML2143
iGMDRD154NSC237663
iGMDRD883CIL55A2
iGMDRD158NSC1415403
iGMDRD103SN-382
iGMDRD705Nakiterpiosin2
iGMDRD105Triptolide1
iGMDRD289Parthenolide6
iGMDRD267Oligomycin A4
iGMDRD872BRD71372
iGMDRD871BRD63682
iGMDRD286Nsc 6328392
iGMDRD367Ro 28-16756
iGMDRD329Merck604
iGMDRD263AACOCF31
iGMDRD246NPC263
iGMDRD300Tozasertib7
iGMDRD886Compound 1541A2
iGMDRD505Pevonedistat2
iGMDRD42Vorinostat2
iGMDRD151CHM-12
iGMDRD1008SR-II-138A2
iGMDRD420Leucascandrolide A7
iGMDRD144NSC953972
iGMDRD670ML 2104
iGMDRD781Sirolimus1
iGMDRD494Neopeltolide3
iGMDRD483SCH-5290743
iGMDRD61Kinetin riboside5
iGMDRD152179324-69-71
iGMDRD634SCHEMBL26080415
iGMDRD474Avrainvillamide4
iGMDRD260FQI-22
iGMDRD782DC-45-A24
iGMDRD171Pemetrexed1
iGMDRD187BRD98762
iGMDRD52Rotenone2
iGMDRD441TW 375
iGMDRD399Selumetinib1
iGMDRD100Zebularine2
iGMDRD188Piperlongumine2
iGMDRD690PRIMA-1MET2
iGMDRD444Tivantinib2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FBN2

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