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FBN2

Summary: The protein encoded by this gene is a component of connective tissue microfibrils and may be involved in elastic fiber assembly. Mutations in this gene cause congenital contractural arachnodactyly. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
fibrillin 2	MIM:612570	Ensembl:ENSG00000138829	HGNC:HGNC:3604	PA28017	5q23.3

Gene Categories:

DRUGGABLE GENOME

GO terms in FBN2

Term Type	Evidence Type	GO Term ID	GO Des.
CC	IDA	GO:0001527	microfibril
CC	TAS	GO:0001527	microfibril
CC	TAS	GO:0005576	extracellular region
CC	HDA	GO:0031012	extracellular matrix
CC	IBA	GO:0031012	extracellular matrix
BP	IBA	GO:0009653	anatomical structure morphogenesis
BP	TAS	GO:0030198	extracellular matrix organization
BP	IEA	GO:0030326	embryonic limb morphogenesis
BP	ISS	GO:0030501	positive regulation of bone mineralization
BP	ISS	GO:0035583	sequestering of TGFbeta in extracellular matrix
BP	IEP	GO:0043010	camera-type eye development
BP	ISS	GO:0045669	positive regulation of osteoblast differentiation
BP	IEP	GO:0048048	embryonic eye morphogenesis
BP	ISS	GO:0060346	bone trabecula formation
MF	IBA	GO:0005201	extracellular matrix structural constituent
MF	IEA	GO:0005509	calcium ion binding
MF	IPI	GO:0005515	protein binding
MF	IC	GO:0030023	extracellular matrix constituent conferring elasticity

Gene expression in normal tissue: FBN2

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FBN2

Database	Pathway ID	Pathway Des.
reactome	R-HSA-1474228	Degradation of the extracellular matrix
reactome	R-HSA-1474244	Extracellular matrix organization
reactome	R-HSA-1474244	Extracellular matrix organization
reactome	R-HSA-1566948	Elastic fibre formation
reactome	R-HSA-1566948	Elastic fibre formation
reactome	R-HSA-2129379	Molecules associated with elastic fibres
reactome	R-HSA-2129379	Molecules associated with elastic fibres
wikipathways	WP3668	Hypothesized Pathways in Pathogenesis of Cardiovascular Disease

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD148	Pifithrin-mu	3
iGMDRD512	nutlin 3	2
iGMDRD405	PIK-75	2
iGMDRD85	Ursolic acid	1
iGMDRD351	GW843682X	7
iGMDRD314	Tanespimycin	1
iGMDRD132	(-)-gallocatechin-3-O-gallate	2
iGMDRD945	ML214	3
iGMDRD154	NSC23766	3
iGMDRD883	CIL55A	2
iGMDRD158	NSC141540	3
iGMDRD103	SN-38	2
iGMDRD705	Nakiterpiosin	2
iGMDRD105	Triptolide	1
iGMDRD289	Parthenolide	6
iGMDRD267	Oligomycin A	4
iGMDRD872	BRD7137	2
iGMDRD871	BRD6368	2
iGMDRD286	Nsc 632839	2
iGMDRD367	Ro 28-1675	6
iGMDRD329	Merck60	4
iGMDRD263	AACOCF3	1
iGMDRD246	NPC26	3
iGMDRD300	Tozasertib	7
iGMDRD886	Compound 1541A	2
iGMDRD505	Pevonedistat	2
iGMDRD42	Vorinostat	2
iGMDRD151	CHM-1	2
iGMDRD1008	SR-II-138A	2
iGMDRD420	Leucascandrolide A	7
iGMDRD144	NSC95397	2
iGMDRD670	ML 210	4
iGMDRD781	Sirolimus	1
iGMDRD494	Neopeltolide	3
iGMDRD483	SCH-529074	3
iGMDRD61	Kinetin riboside	5
iGMDRD152	179324-69-7	1
iGMDRD634	SCHEMBL2608041	5
iGMDRD474	Avrainvillamide	4
iGMDRD260	FQI-2	2
iGMDRD782	DC-45-A2	4
iGMDRD171	Pemetrexed	1
iGMDRD187	BRD9876	2
iGMDRD52	Rotenone	2
iGMDRD441	TW 37	5
iGMDRD399	Selumetinib	1
iGMDRD100	Zebularine	2
iGMDRD188	Piperlongumine	2
iGMDRD690	PRIMA-1MET	2
iGMDRD444	Tivantinib	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FBN2

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.