RIOK3
Summary: This gene was first identified by the similarity of its product to the Aspergillus nidulans SUDD protein. This gene is now recognized as a member of the right open reading frame (RIO) kinase gene family. This gene encodes a serine/threonine kinase that localizes to the cytoplasm and plays a role in the processing of the pre-40 S ribosomal subunit. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RIO kinase 3 | MIM:603579 | Ensembl:ENSG00000101782 | HGNC:HGNC:11451 | PA36248 | 18q11.2 |
GO terms in RIOK3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IDA | GO:0089720 | caspase binding |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007059 | chromosome segregation |
| BP | IBA | GO:0030490 | maturation of SSU-rRNA |
| BP | IMP | GO:0030490 | maturation of SSU-rRNA |
| BP | IDA | GO:0032463 | negative regulation of protein homooligomerization |
| BP | IMP | GO:0032728 | positive regulation of interferon-beta production |
| BP | IMP | GO:0039534 | negative regulation of MDA-5 signaling pathway |
| BP | IDA | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0045087 | innate immune response |
| BP | IMP | GO:0045089 | positive regulation of innate immune response |
| BP | IEA | GO:0051607 | defense response to virus |
| BP | IMP | GO:0071359 | cellular response to dsRNA |
| BP | IMP | GO:0098586 | cellular response to virus |
| BP | IMP | GO:1990786 | cellular response to dsDNA |
| CC | IBA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0030688 | preribosome, small subunit precursor |
| CC | IDA | GO:0030688 | preribosome, small subunit precursor |
Gene expression in normal tissue: RIOK3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RIOK3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol |
| reactome | R-HSA-72312 | rRNA processing |
| reactome | R-HSA-8868773 | rRNA processing in the nucleus and cytosol |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| wikipathways | WP2849 | Hematopoietic Stem Cell Differentiation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD435 | BI-2536 | 6 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD150 | RITA | 3 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD151 | CHM-1 | 6 |
| iGMDRD584 | VER 155008 | 1 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD60 | Quinoclamine | 6 |
| iGMDRD871 | BRD6368 | 4 |
| iGMDRD506 | Fedratinib | 6 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD260 | FQI-2 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RIOK3
CLASSFICATION
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