RIOK3


Summary: This gene was first identified by the similarity of its product to the Aspergillus nidulans SUDD protein. This gene is now recognized as a member of the right open reading frame (RIO) kinase gene family. This gene encodes a serine/threonine kinase that localizes to the cytoplasm and plays a role in the processing of the pre-40 S ribosomal subunit. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
RIO kinase 3MIM:603579Ensembl:ENSG00000101782HGNC:HGNC:11451PA3624818q11.2

GO terms in RIOK3


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0046872metal ion binding
MFIDAGO:0089720caspase binding
BPIEAGO:0006468protein phosphorylation
BPTASGO:0007059chromosome segregation
BPIBAGO:0030490maturation of SSU-rRNA
BPIMPGO:0030490maturation of SSU-rRNA
BPIDAGO:0032463negative regulation of protein homooligomerization
BPIMPGO:0032728positive regulation of interferon-beta production
BPIMPGO:0039534negative regulation of MDA-5 signaling pathway
BPIDAGO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling
BPIEAGO:0045087innate immune response
BPIMPGO:0045089positive regulation of innate immune response
BPIEAGO:0051607defense response to virus
BPIMPGO:0071359cellular response to dsRNA
BPIMPGO:0098586cellular response to virus
BPIMPGO:1990786cellular response to dsDNA
CCIBAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIBAGO:0030688preribosome, small subunit precursor
CCIDAGO:0030688preribosome, small subunit precursor

Gene expression in normal tissue: RIOK3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RIOK3


DatabasePathway IDPathway Des.
reactomeR-HSA-6791226Major pathway of rRNA processing in the nucleolus and cytosol
reactomeR-HSA-72312rRNA processing
reactomeR-HSA-8868773rRNA processing in the nucleus and cytosol
reactomeR-HSA-8953854Metabolism of RNA
wikipathwaysWP2849Hematopoietic Stem Cell Differentiation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD280CYTOCHALASIN B5
iGMDRD123Isoevodiamine3
iGMDRD435BI-25366
iGMDRD193Fqi13
iGMDRD150RITA3
iGMDRD546BMS-7548073
iGMDRD144NSC953972
iGMDRD151CHM-16
iGMDRD584VER 1550081
iGMDRD420Leucascandrolide A3
iGMDRD60Quinoclamine6
iGMDRD871BRD63684
iGMDRD506Fedratinib6
iGMDRD271Brefeldin A3
iGMDRD474Avrainvillamide3
iGMDRD260FQI-21

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RIOK3

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