RIOK3

Summary: This gene was first identified by the similarity of its product to the Aspergillus nidulans SUDD protein. This gene is now recognized as a member of the right open reading frame (RIO) kinase gene family. This gene encodes a serine/threonine kinase that localizes to the cytoplasm and plays a role in the processing of the pre-40 S ribosomal subunit. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameRIO kinase 3
OMIM IDMIM:603579
Ensembl IDEnsembl:ENSG00000101782
HGNC IDHGNC:HGNC:11451
PHARMGKB IDPA36248
Map Location18q11.2

GO terms in RIOK3


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0004674 protein serine/threonine kinase activity
MF IDA GO:0004674 protein serine/threonine kinase activity
MF IPI GO:0005515 protein binding
MF IEA GO:0005524 ATP binding
MF IEA GO:0046872 metal ion binding
MF IDA GO:0089720 caspase binding
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Gene expression in normal tissue: RIOK3

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 36LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 15BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 3BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 4

Gene-drug pathway distribution

undefined13Other, kinases1Cell cycle1IGFR signaling1

Pathways in RIOK3


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Database
Pathway ID
Pathway Des.
reactome R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
reactome R-HSA-72312 rRNA processing
reactome R-HSA-8868773 rRNA processing in the nucleus and cytosol
reactome R-HSA-8953854 Metabolism of RNA
wikipathways WP2849 Hematopoietic Stem Cell Differentiation
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD280 CYTOCHALASIN B 5
iGMDRD123 Isoevodiamine 3
iGMDRD435 BI-2536 6
iGMDRD193 Fqi1 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RIOK3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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